Patents by Inventor Isamu Oh
Isamu Oh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130096097Abstract: [Problem] The purpose of the present invention is to provide organic particles containing pharmaceutical particles of which the particles are small and the particle size distribution is narrow, and a manufacturing method for the same. [Solution] Provided are pharmaceutical multimeric particles of which the particles are small and the particle size distribution is narrow and which are characterized in being obtained by pouring into water a solution of a pharmaceutical multimer dissolved in a water-miscible organic solvent, and a manufacturing method for the pharmaceutical multimeric particles. Pharmaceutical dimeric particles thereof are characterized in being obtained by pouring into water a solution of a compound represented by general formula (I) dissolved in a water-miscible organic solvent.Type: ApplicationFiled: June 7, 2011Publication date: April 18, 2013Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Hitoshi Kasai, Hachiro Nakanishi, Koichi Baba, Hidetoshi Oikawa, Tastuya Murakami, Hiroshi Imahori, Misturu Hashida, Isamu Oh
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Patent number: 7900855Abstract: The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.Type: GrantFiled: February 7, 2008Date of Patent: March 8, 2011Assignee: ABsize, Inc.Inventors: Tsuyoshi Asahi, Hiroshi Masuhara, Teruki Sugiyama, Isamu Oh, Sen-ichi Ryo
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Patent number: 7815426Abstract: An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.Type: GrantFiled: May 15, 2007Date of Patent: October 19, 2010Assignee: ABsize Inc.Inventors: Hiroyuki Kato, Isao Umeda, Tsuyoshi Asahi, Hiroshi Masuhara, Teruki Sugiyama, Isamu Oh, Sen-ichi Ryo, Kazuya Hirata, Motohiko Nohmi
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Publication number: 20100068794Abstract: (Problems) To provide a cell fusion chip, which allows to perform a cell fusion on a single chip, excels in the operating efficiency, does not require experience so much in cell feed or recovery, and has no risk of the contamination to the cells during the operation. (Means for Solving Problems) The present invention provides a cell fusion chip comprising: an isolation chamber for receiving isolated cells to be subjected to an fusion operation; a fusion chamber for fusing the cells together supplied from the isolation chamber; a culture chamber for culturing the cells fused in the fusion chamber; a first channel for connecting the isolation chamber and the fusion chamber; and a second channel for connecting the fusion chamber and the culture chamber, wherein the isolation chamber, the fusion chamber, the culture chamber, the first channel and the second channel are formed on a single chip.Type: ApplicationFiled: March 27, 2007Publication date: March 18, 2010Applicant: AB size Inc.Inventors: Isamu Oh, Hiroshi Masuhara, Toshiyuki t Yamato, Katsuaki Hayashi, Yasuji Adachi, Sato Setsuya
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Publication number: 20100066880Abstract: [Problems] To provide a microchip for cell sorting to obtain the desired cell from a number of cells quickly and accurately by combining the advantages from both methods using the optical tweezer and the liquid supply to the micro channel. [Means for solving problems] A microchip for sorting at least one cell including a base, the base comprising: a cell supply channel for supplying and flowing a liquid containing cells; a cell supply channel including an inlet port in liquid communication with a supply mechanism and a drain port in liquid communication with a drain mechanism; a cell sorting channel intersecting with the cell supply channel at their middle point, the cell sorting channel including an inlet port in liquid communication with a supply mechanism and a drain port in liquid communication with a drain mechanism.Type: ApplicationFiled: June 15, 2007Publication date: March 18, 2010Applicant: ABsize INC.Inventors: Setsuya Sato, Toshiyuki Yamato, Katsuaki Hayashi, Yoshitaka Matsumoto, Isamu Oh
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Publication number: 20100043882Abstract: [Problems] To provide a microchip for cell arranging which transfers and arranges the cell accurately and quickly, by combining advantages of the method of an optical tweezer and of micro channel.Type: ApplicationFiled: June 15, 2007Publication date: February 25, 2010Applicant: ABsize Inc.Inventors: Setsuya Sato, Toshiyuki Yamato, Katsuaki Hayashi, Yoshitaka Matsumoto, Takahiro Ochiya, Isamu Oh
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Patent number: 7597278Abstract: A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.Type: GrantFiled: May 15, 2007Date of Patent: October 6, 2009Assignees: Osaka University, Absize, Inc., Ebara CorporationInventors: Tsuyoshi Asahi, Hiroshi Masuhara, Teruki Sugiyama, Isamu Oh, Sen-ichi Ryo, Hiroyuki Kato, Isao Umeda
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Publication number: 20080237376Abstract: A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.Type: ApplicationFiled: May 15, 2007Publication date: October 2, 2008Inventors: Tsuyoshi Asahi, Hiroshi Masuhara, Teruki Sugiyama, Isamu Oh, Sen-ichi Ryo, Hiroyuki Kato, Isao Umeda
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Publication number: 20080217445Abstract: The present invention provides a fullerene suspension and a method for producing a fullerene suspension having high dispersion stability without any chemical compound. Also, the fullerene suspension and its producing method makes it possible to be applied in various fields including the field of medical and pharmaceutical science and the field of foods and environment, in which the fullerene suspension obtained by the prior methods had not been applied. The fullerene is ground to form nanoparticles by irradiating a fullerene in a poor solvent with a laser. The pulse laser having a width of several-ten femtoseconds to several-hundred nanoseconds is appropriately applied.Type: ApplicationFiled: February 7, 2008Publication date: September 11, 2008Inventors: Tsuyoshi Asahi, Hiroshi Masuhara, Teruki Sugiyama, Isamu Oh, Sen-ichi Ryo
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Publication number: 20080057558Abstract: The present invention provides a method and an apparatus for selectively removing non-target cells from a mixed cell population of different types of cells to selectively separate target cells. Individual cells or cell groups of at least two cells from a mixed cell population of different types of cells are placed on a certain two-dimensional, coordinate system. Then a distinction is made among the individual cells or cells in the cell groups, based on the shape or size of the cells or by using a cell marker. Physical energy such as laser light is applied to the positions or regions occupied by non-target cells or cell groups including non-target cells in order to selectively kill the non-target cells or cause dysfunction of the non-target cells.Type: ApplicationFiled: August 15, 2007Publication date: March 6, 2008Inventors: Hideo Niwa, Akira Kobayashi, Setsuya Sato, Yoshitaka Matsumoto, Isamu Oh
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Publication number: 20070284769Abstract: An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.Type: ApplicationFiled: May 15, 2007Publication date: December 13, 2007Applicants: EBARA CORPORATION, Osaka University, ABsize Inc.Inventors: Hiroyuki Kato, Isao Umeda, Tsuyoshi Asahi, Hiroshi Masuhara, Teruki Sugiyama, Isamu Oh, Sen-ichi Ryo, Kazuya Hirata, Motohiko Nohmi
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Publication number: 20050276456Abstract: The present invention provides a cell-operating device comprising a laser light source and a microscope to observe cell sample fluorescently labeled and a camera to take the images of the cell sample that is observed with said microscope and a computer to capture the digital image data obtained by said camera and a group of mirrors comprising electronic control mirrors of which optical axis can be adjusted so that the laser light irradiated from said laser light source can be guided in to said microscope. The computer includes a binarization program for binarizing said digital image data by identifying whether each pixel of said digital image data captures a part of said cell sample according to the fluorescence luminance of each pixel.Type: ApplicationFiled: May 26, 2005Publication date: December 15, 2005Inventors: Toshiyuki Yamato, Yoshitaka Matsumoto, Katsuaki Hayashi, Isamu Oh, Setsuya Sato