Patents by Inventor Isamu Sakabe

Isamu Sakabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene shinc-3 and diagnostic and therapeutic uses thereof
    Patent number: 7244565
    Abstract: The invention provides a SHINC-3 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-3 protein, or a complementary polynucleotide or antisense polynucleotide. In another aspect, the invention provides a SHINC-3 polypeptide, which can be a full-length SHINC-3 protein or a fragment thereof or an analog or homolog thereof. Desirably, the SHINC-3 polypeptide modulates apoptosis. In another aspect, the invention provides an antibody that specifically binds a SHINC-3 polypeptide. In another aspect, the invention provides diagnostic methods. For example, the method affords a method for identifying compounds that modulate apoptosis. In another aspect, the invention provides a method for detecting or evaluating the prognosis of a cancer. In another aspect, the invention provides diagnostic compositions for detection of cancer.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: July 17, 2007
    Assignee: Georgetown University
    Inventors: Usha Kasid, Isamu Sakabe, Imran Ahmad
  • Gene SHINC-2 and diagnostic and therapeutic uses thereof
    Patent number: 7138512
    Abstract: The invention provides a SHINC-2 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-2 protein, or a complementary polynucleotide or antisense polynucleotide. The invention provides a SHINC-2 polypeptide, which can be a full-length SHINC-2 protein or a fragment thereof or an analog or homolog thereof. Desirably, the SHINC-2 polypeptide modulates apoptosis. The invention provides an antibody that specifically binds a SHINC-2 polypeptide. The invention provides diagnostic methods. For example, the invention affords a method for identifying compounds that modulate apoptosis. The invention provides a method for detecting or evaluating the prognosis of a cancer. The invention provides diagnostic compositions for detection of cancer. The invention provides a method of modulating apoptosis or treating or preventing a cancer, tumor growth and/or metastasis by administration of an agent that modulates the expression and/or activity of SHINC-2.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: November 21, 2006
    Assignee: Georgetown University
    Inventors: Usha Kasid, Isamu Sakabe, Imran Ahmad
  • Gene SHINC-1 and diagnostic and therapeutic uses thereof
    Publication number: 20040161775
    Abstract: The partial DNA sequence of new gene SHINC-1 is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of SHINC-1 such as breast cancer, leukemia, lymphoma, melanoma, colorectal cancer, and lung cancer.
    Type: Application
    Filed: October 6, 2003
    Publication date: August 19, 2004
    Applicants: Georgetown University, NeoPharm, Inc.
    Inventors: Usha Kasid, Isamu Sakabe, Simeng Suy, Deepak Kumar, Imran Ahmad
  • Gene shinc-3 and diagnostic and therapeutic uses thereof
    Publication number: 20040005603
    Abstract: The invention provides a SHINC-3 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-3 protein, or a complementary polynucleotide or antisense polynucleotide. In another aspect, the invention provides a SHINC-3 polypeptide, which can be a full-length SHINC-3 protein or a fragment thereof or an analog or homolog thereof. Desirably, the SHINC-3 polypeptide modulates apoptosis. In another aspect, the invention provides an antibody that specifically binds a SHINC-3 polypeptide.
    Type: Application
    Filed: April 10, 2003
    Publication date: January 8, 2004
    Applicants: Georgetown University, NeoPharm, Inc.
    Inventors: Usha Kasid, Isamu Sakabe, Imran Ahmad
  • Gene SHINC-2 and diagnostic and therapeutic uses thereof
    Publication number: 20030225023
    Abstract: The invention provides a SHINC-2 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-2 protein, or a complementary polynucleotide or antisense polynucleotide. In another aspect, the invention provides a SHINC-2 polypeptide, which can be a full-length SHINC-2 protein or a fragment thereof or an analog or homolog thereof Desirably, the SHINC-2 polypeptide modulates apoptosis. In another aspect, the invention provides an antibody that specifically binds a SHINC-2 polypeptide.
    Type: Application
    Filed: April 10, 2003
    Publication date: December 4, 2003
    Applicants: Georgetown University, NeoPharm, Inc.
    Inventors: Usha Kasid, Isamu Sakabe, Imran Ahmad