Abstract: The present invention provides a method of cell culture comprising adding a cell-containing seed medium to an initial medium and starting to culture the cell in the initial medium, wherein the initial medium has an organism-derived culture medium additive added thereto and the amount of the C-terminal amidated species in the produced protein is controlled by the copper content of the initial medium at the start of cell culture.

Abstract: The present invention provides a method of cell culture comprising adding a cell-containing seed medium to an initial medium and starting to culture the cell in the initial medium, wherein the initial medium has an organism-derived culture medium additive added thereto and the amount of the C-terminal amidated species in the produced protein is controlled by the copper content of the initial medium at the start of cell culture.

Abstract: An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody subtype (2) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which both C-terminals of the heavy chain are Pro-NH2 (447), and a pharmaceutical composition comprising them.

Abstract: An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody subtype (2) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which both C-terminals of the heavy chain are Pro-NH2 (447), and a pharmaceutical composition comprising them.

Abstract: An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody subtype (2) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which both C-terminals of the heavy chain are Pro-NH2 (447), and a pharmaceutical composition comprising them.

Abstract: The present invention provides a method of cell culture comprising adding a cell-containing seed medium to an initial medium and starting to culture the cell in the initial medium, wherein the initial medium has an organism-derived culture medium additive added thereto and the amount of the C-terminal amidated species in the produced protein is controlled by the copper content of the initial medium at the start of cell culture.

Abstract: An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody subtype (2) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which both C-terminals of the heavy chain are Pro-NH2 (447), and a pharmaceutical composition comprising them.

Abstract: An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody subtype (2) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which both C-terminals of the heavy chain are Pro-NH2 (447), and a pharmaceutical composition comprising them.

Abstract: An antibody subtype (1) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which one C-terminal of the heavy chain is Pro-NH2 (447), and an antibody subtype (2) which is a subtype of the humanized PM-1 antibody against interleukin-6 receptor (IL-6R) and in which both C-terminals of the heavy chain are Pro-NH2 (447), and a pharmaceutical composition comprising them.

Abstract: As a subtype of humanized PM-1 antibody against interleukin-6 receptor (IL-6R), there is provided antibody sub-type (1) whose one heavy chain C terminus consists of Pro-NH2 (447). As another subtype of humanized PM-1 antibody against interleukin-6 receptor (IL-6R), there is provided antibody subtype (2) whose both heavy chain C termini consist of Pro-NH2 (447). Furthermore, there are provided pharmaceutical compositions comprising these.

Abstract: As a subtype of humanized PM-1 antibody against interleukin-6 receptor (IL-6R), there is provided antibody sub-type (1) whose one heavy chain C terminus consists of Pro-NH2 (447). As another subtype of humanized PM-1 antibody against interleukin-6 receptor (IL-6R), there is provided antibody subtype (2) whose both heavy chain C termini consist of Pro-NH2 (447). Furthermore, there are provided pharmaceutical compositions comprising these.

Abstract: A projection lens unit compensates for thermal expansion and contraction. The unit comprises a coupler at the front surface of a CRT, a lens unit body for projecting an image onto a screen by controlling and magnifying the light from the CRT, a plurality of legs secured to the coupler for supporting the lens unit body at more than three points, a slide mechanism (latch arms and latch engaging slots provided between the legs and the lens unit body for slidably supporting the legs for movement along the optical axis relative to the lens unit body, and expansion/contraction bars provided between the legs and the lens unit body for compensating for the thermally induced expansion/contraction, with one end engaged with a leg and the other end engaged with the base of the lens unit body.

Abstract: A projection lens unit, which is small, compatible and highly capable of compensating for the changes in temperature, is provided. The unit comprises a coupler 5 provided at the front surface of a CRT 1, a lens unit body 6 for projecting an image onto a screen by controlling and magnifying the light from the CRT 1, a plurality of leg portions 7 secured to the coupler 5 for supporting the lens unit body 6 at more than three points, a slide mechanism (latches 58 and latch engaging slots 42) provided between the leg portions 7 and the lens unit body 6 for slidably supporting the leg portions 7 in the direction of optical axis in relation to the lens unit body 6, and an expansion/contraction bars 8 provided between the leg portions 7 and the lens unit body 6 for compensating for the effect of heat with one end engaged with the tip end side of the leg portions 7 and the other end with the base end side of the lens unit body 6.

Abstract: An image forming apparatus in which a distance along a photosensitive belt from a cleaning unit to an exposing position is set to be shorter than a distance from the rear end of a print image to the front end of the following print image, so that a latent image is not formed by an exposing unit when a joint of the photosensitive belt passes the cleaning unit.

Abstract: A toner bearing body unit is constituted as one assembled unit including a toner bearing body for holding toners supplied from a toner supply roller of a housing main body at an outer peripheral surface thereof, a toner layer thickness regulating member for electrically charging the toners by applying pressure toward the outer peripheral surface of the toner bearing body and for forming a toner thin layer on the toner bearing body, and a holding member for holding the toner bearing body and the toner layer thickness regulating member. The toner bearing body unit is constituted to be directly attachable to and detachable from an outer side of the housing main body of a developing apparatus. Accordingly, an uniform toner thin layer having a predetermined thickness can be formed stably on the toner bearing body during a long period of use, and the developing apparatus reconstructed so that replacement of the components thereof can be carried out easily.

Abstract: A developing apparatus includes toner powder in the form of fine colored powder, a toner carrier, and a frictional controlling member for contacting under a pressure with the toner carrier under pressure to frictionally charge the toner powder and form a thin toner layer on the toner carrier. The toner carrier on which the thin toner layer is formed is rotated so as to transport the thin toner layer to an opposing location on a toner image carrier on which an electrostatic latent image is formed to convert the electrostatic latent image into a visible image. The developing apparatus includes a toner supply roller disposed in rotating contact with the toner carrier at a side of the toner carrier, the frictional controlling member being provided at a position in contact with the toner carrier downstream of the toner supply roller; and a rotatable toner scraping member is provided in a neighboring relationship below the toner supply roller and the frictional controlling member.

Abstract: An electrophotographic imaging apparatus includes a toner image holding body, a transcription unit for transcribing the toner image on the toner image holding body onto a recording medium, and a conveyor for conveying a recording medium toward the toner image holding body and transcription unit. A judging device will judge whether printing is of a first page or not and if it is decided that printing is to be performed on a first page, a first measuring device will measure the electrical characteristic of the toner image holding body prior to the feeding of a recording medium and a transcription voltage will be set depending of this measured result. Thereafter, the recording medium will be conveyed toward the transcription unit where the electrical characteristics of the non-printing region on the recording medium will be measured via a second measuring device and the transcription voltage will be further adjusted.

Abstract: A developing magnet roller is provided on a developing frame, and a developing agent accommodating cartridge and a toner accommodating cartridge member are fitted detachably into the developing frame. The toner accommodating cartridge member is fitted detachably into the developing agent accommodating cartridge. A developing agent is recovered in the developing agent accommodating cartridge. The developing agent and the developing agent accommodating cartridge are exchanged together from a developing apparatus. The new developing agent accommodated in the exchanged new developing agent accommodating cartridge is circulated by the developing magnet roller. The exchange for the developing agent in the developing apparatus can be realized without the lowering of the developing performance.

Abstract: An intermediate transcription drum is supported so as to be driven in contacting relationship with a photosensitive belt. The rotating speed of the photosensitive belt driving motor is controlled by a control unit such that one rotation cycle of the intermediate transcription drum becomes a given cycle. An adjustment of the speed control data for the photosensitive belt driving motor is performed in the interval between electrostatic latent image forming. Thereby, a speed difference between the photosensitive belt and the intermediate transcription drum does not occur, and a plurality of the toner images can be transferred and accurately superposed onto the outer surface of the intermediate transcription drum.

Abstract: The disclosure is concerned with an electrophotographic apparatus comprising a toner image supporting member on which a toner image developed on an electrostatic latent image is formed, transferring means for transferring the toner image on said toner image supporting member to a recording medium, conveying means for bringing the recording medium into contact with the image supporting member, a fixing roller and a compression roller in contact with each other to fix the toner image on the recording medium, heating means disposed inside at least one of the fixing roller and the compression roller, wherein there are provided temperature detection means for detecting the surface temperature of the fixing roller and state detection means for detecting the state of the fixing apparatus before starting of the fixing apparatus.