Patents by Inventor Isan Chen

Isan Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL-FREE METHODS OF PRODUCING ANTIBODIES TO INTRACELLULAR TARGETS
    Publication number: 20240068004
    Abstract: Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modified cell-free systems for use in such methods in which the cell free protein expression system is modified by an agent which binds to the intracellular target protein or to the antibody paratope and thus prevents the antibody from binding to the target protein.
    Type: Application
    Filed: May 2, 2023
    Publication date: February 29, 2024
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Yongjian Wu, Fernanda I. Staquicini, Isan Chen
  • CELL-FREE METHODS OF RECOMBINANT ANTIBODY PRODUCTION
    Publication number: 20240010714
    Abstract: Provided herein are methods and cell-free systems for production of a recombinant antibody in which the antibody is directed against a target protein that is natively expressed as an intracellular protein. Also provided herein are modified cell-free systems for use in such methods in which the modified system is engineered to express a variant target protein that has a mutant epitope of the target epitope of an antibody.
    Type: Application
    Filed: May 2, 2023
    Publication date: January 11, 2024
    Applicant: MBrace Therapeutics, Inc.
    Inventors: Yongjian Wu, Fernanda I. Staquicini, Isan Chen
  • Androgen Receptor Modulator And Uses Thereof
    Publication number: 20210177821
    Abstract: Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.
    Type: Application
    Filed: February 25, 2021
    Publication date: June 17, 2021
    Inventors: Isan Chen, Jeffrey H. Hager, Edna Chow Maneval, Mark R. Herbert, Nicholas D. Smith
  • Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer
    Publication number: 20210000812
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Application
    Filed: September 11, 2020
    Publication date: January 7, 2021
    Inventor: Isan Chen
  • Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
    Patent number: 10849888
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: December 1, 2020
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventor: Isan Chen
  • Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
    Patent number: 10799488
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: October 13, 2020
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventor: Isan Chen
  • Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
    Patent number: 10799489
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: October 13, 2020
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventor: Isan Chen
  • Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer
    Publication number: 20190269668
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Application
    Filed: May 20, 2019
    Publication date: September 5, 2019
    Inventor: Isan Chen
  • Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer
    Publication number: 20190269667
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Application
    Filed: May 17, 2019
    Publication date: September 5, 2019
    Inventor: Isan Chen
  • Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer
    Publication number: 20180318277
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Application
    Filed: July 12, 2018
    Publication date: November 8, 2018
    Inventor: Isan Chen
  • Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
    Patent number: 10052314
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: August 21, 2018
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventor: Isan Chen
  • Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer
    Patent number: 10034860
    Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: July 31, 2018
    Assignee: Genentech, Inc.
    Inventors: Edna Chow Maneval, Boa Tran H. Troung, Isan Chen, Jeffrey H. Hager, Debasish F. Roychowdhury
  • Anti-Androgens For The Treatment Of Non-Metastatic Castrate-Resistant Prostate Cancer
    Publication number: 20180110764
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Application
    Filed: December 21, 2017
    Publication date: April 26, 2018
    Inventor: Isan Chen
  • Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
    Patent number: 9884054
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: February 6, 2018
    Assignee: ARAGON PHARMACEUTICALS, INC.
    Inventor: Isan Chen
  • ESTROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF LOCALLY ADVANCED OR METASTATIC ESTROGEN RECEPTOR POSITIVE BREAST CANCER
    Publication number: 20170239219
    Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
    Type: Application
    Filed: May 8, 2017
    Publication date: August 24, 2017
    Applicant: Genentech, Inc.
    Inventors: Edna Chow Maneval, Boa Tran H. Troung, Isan Chen, Jeffrey H. Hager, Debasish F. Roychowdhury
  • Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer
    Patent number: 9675586
    Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: June 13, 2017
    Assignee: Genentech, Inc.
    Inventors: Edna Chow Maneval, Boa Tran H. Truong, Isan Chen, Jeffrey H. Hager, Debasish F. Roychowdhury
  • ANDROGEN RECEPTOR MODULATOR AND USES THEREOF
    Publication number: 20160220548
    Abstract: Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.
    Type: Application
    Filed: April 8, 2016
    Publication date: August 4, 2016
    Inventors: ISAN CHEN, JEFFREY H. HAGER, EDNA CHOW MANEVAL, MARK R. HERBERT, NICHOLAS D. SMITH
  • Androgen receptor modulator and uses thereof
    Patent number: 9340524
    Abstract: Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions that are amenable to treatment with the androgen receptor modulator, as well as pharmaceutical compositions and medicaments that include such compound.
    Type: Grant
    Filed: January 9, 2014
    Date of Patent: May 17, 2016
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventors: Isan Chen, Jeffrey H Hager, Edna Chow Maneval, Mark R Herbert, Nicholas D Smith
  • ESTROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF LOCALLY ADVANCED OR METASTATIC ESTROGEN RECEPTOR POSITIVE BREAST CANCER
    Publication number: 20150157606
    Abstract: Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 11, 2015
    Inventors: Edna Chow Maneval, Boa Tran H. Truong, Isan Chen, Jeffrey H. Hager, Debasish F. Roychowdhury
  • Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
    Patent number: RE49353
    Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: January 3, 2023
    Assignee: Aragon Pharmaceuticals, Inc.
    Inventor: Isan Chen