Patents by Inventor Isao Date

Isao Date has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preventing cerebral vasospasm with anti-HMGB1 antibody
    Patent number: 8071098
    Abstract: An objective of the present invention is to provide a cerebral vasospasm inhibitor which is effective on cerebral vasospasm occurring after subarachnoid hemorrhage and has few side-effects. The cerebral vasospasm inhibitor of the invention is characterized in containing an anti-HMGB1 monoclonal antibody as an active ingredient.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: December 6, 2011
    Assignee: National University Corporation Okayama University
    Inventors: Masahiro Nishibori, Shuji Mori, Hideo Takahashi, Yasuko Tomono, Isao Date, Shigeki Ono
  • Cerebral Vasospasm Inhibitor
    Publication number: 20090175878
    Abstract: An objective of the present invention is to provide a cerebral vasospasm inhibitor which is effective on cerebral vasospasm occurring after subarachnoid hemorrhage and has few side-effects. The cerebral vasospasm inhibitor of the invention is characterized in containing an anti-HMGB1 monoclonal antibody as an active ingredient.
    Type: Application
    Filed: May 18, 2007
    Publication date: July 9, 2009
    Inventors: Masahiro Nishibori, Shuji Mori, Hideo Takahashi, Yasuko Tomono, Isao Date, Shigeki Ono
  • Brain-protective agent
    Patent number: 6890909
    Abstract: A brain-protective agent containing an NF-?B decoy. In brain diseases, the brain can be particularly effectively protected against brain disorders (for example, cerebral vasospasm following a subrachnoidal hemorrhage and apoptosis of the nerve cells following a cerebrovasucular accident or serious head injury) caused by the undesired activation of cytokines or cell adhesion factors which are regulated by NF-?B by administering the brain-protective agent containing an NF-?B decoy, i.e., acompound antadonistic specifically to a nucleic acid to which NF-?B binds.
    Type: Grant
    Filed: July 3, 1998
    Date of Patent: May 10, 2005
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigeki Ono, Isao Date
  • Brain-protective agent
    Publication number: 20040063614
    Abstract: A brain-protective agent containing an NF-&kgr;B decoy. In brain diseases, the brain can be particularly effectively protected against brain disorders (for example, cerebral vasospasm following a subrachnoidal hemorrhage and apoptosis of the nerve cells following a cerebrovasucular accident or serious head injury) caused by the undesired activation of cytokines or cell adhesion factors which are regulated by NF-&kgr;B by administering the brain-protective agent containing an NF-&kgr;B decoy, i.e., a compound antadonistic specifically to a nucleic acid to which NF-&kgr;B binds.
    Type: Application
    Filed: October 3, 2003
    Publication date: April 1, 2004
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Shigeki Ono, Isao Date