Patents by Inventor Isao Kaetsu

Isao Kaetsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5152758
    Abstract: An electroresponsive hydrogel produced by alkali hydrolysis of a copolymer comprising N-isopropylacrylamide, an ionic monomer and a crosslinking agent; and a physiologically active substance release control system comprising a biosensor, an amplifier and an electroresponsive hydrogel containing physiologically active substance are disclosed. The hydrogel of the present invention is capable of releasing a physiologically active substance alone in an amount corresponding to the applied voltage with excellent reproducibility by contracting and reswelling in good response to the loading and unloading of an external stimulation voltage, it can be advantageously used in a physiologically active substance release control system capable of releasing an essential physiologically active substance in a necessary amount according to changes in physiological conditions.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: October 6, 1992
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventors: Isao Kaetsu, Yasushi Morita, Akira Ohtori
  • Patent number: 5061057
    Abstract: In order to make hard and soft contact lenses having a pore diameter and a pore density optimum for use as oxygen permeable contact lenses, the contact lens after molding is subjected to irradiation of a polyvalent heavy ion beam having a mass number of 2 to 100 (preferably 10 to 80) and an ion energy of 10M eV (preferably 50M eV) or higher, at an ion radiation density of 10 to 10.sup.9 ions/cm.sup.2 (preferably 10.sub.2 to 10.sub.5 ions/cm.sup.2) and thereafter ultrasonically etched (preferably at 10 to 50 MHz) at a temperature of 4 to 50.degree. C. (preferably 10.degree. to 30.degree. C.) in the presence of chloroacetic acid (preferably tricholoracetic acid).
    Type: Grant
    Filed: May 25, 1989
    Date of Patent: October 29, 1991
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Minoru Kumakura, Isao Kaetsu, Yoshihide Komaki, Tsutomu Sakurai, Ryuji Arai, Yasuji Sejima, Takashi Ohno, Toshiyuki Itoh, Hideo Kohyama
  • Patent number: 4981798
    Abstract: A carrier for immobilization of microorganisms is prepared by impregnating a fabric such as cotton gauze having a mesh size of 10-50 with 20-50% by weight of a vinyl monomer such as ethlene glycol methacrylate and polymerizing the monomer with ionizing radiation to form a polymer coating on the fabric. A microorganism such as Trichoderma reesei is grown in a liquid culture medium in contact with the polymer-coated fabric and the polymer-coated fabric is recovered containing growing cells of the microorganism. The polymer-coated fabric has high air permeability and permits good diffusion of liquid culture medium.
    Type: Grant
    Filed: August 1, 1989
    Date of Patent: January 1, 1991
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Minoru Kamakura, Masao Tamada, Noboru Kasai, Isao Kaetsu, Shigeru Yamanaka
  • Patent number: 4912000
    Abstract: An electrophotographic photoreceptor comprises an electrically conductive support, a photoconductive layer provided thereon, and a protective layer coated on the photoconductive layer, wherein the protective layer comprises a product of uncatalized hydrolysis of a composition essentially consisting of at least one specific epoxysilane compound, at least one specific alkylalkoxysilane compound, and at least one specific aminosilane compound. The photoreceptor is very useful in that it is free from wear due to friction with paper and cleaning members, keeps high resolving power, and is sufficiently proof against continuous copying under conditions of high temperature and high humidity.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: March 27, 1990
    Assignees: Japan Atomic Energy Research Institute, Shindengen Electric Manufacturing Co., Yamanashi Electronics Co., Ltd.
    Inventors: Minoru Kumakura, Isao Kaetsu, Masahiro Horigome, Tsuneo Isomura, Tomio Yoneyama, Tadaichi Murata
  • Patent number: 4904708
    Abstract: Hydrophilic monomers in a supercooled, transparent state, are polymerized in the presence of water. The polymers have low levels of residual monomers and exhibit good mechanical strength. The process provides materials useful as contact lenses.
    Type: Grant
    Filed: May 31, 1988
    Date of Patent: February 27, 1990
    Assignees: Japan Atomic Energy Research Institute, Kabushiki Kaisha Tokyo Contact Lens Kenkyusho
    Inventors: Isao Kaetsu, Minoru Kumakura, Hidenari Suyama, Nobuo Kameda, Hideo Kouyama
  • Patent number: 4839109
    Abstract: A mixture of a specified siloxanylalkyl ester monomer and a specified vinyl monomer is polymerized by exposure to an ionizing radiation at low temperatures and the resulting polymer is worked with a lathe cut to form a contact lens. The contact lens obtained is free from any optical distortion, has good dimensional stability and exhibits high oxygen permeability. In a preferred embodiment, a monomer mixture comprising a siloxanylalkyl ester, a methacrylate or acrylate, N-vinylpyrrolidone, and a small amount of a dimethacrylate or diacrylate is exposed to a total dose of 1.times.10.sup.5 -5.times.10.sup.6 roentgens at a low temperature (-80.degree. C. to -20.degree. C. and at a dose rate of 8.times.10.sup.4 -2.times.10.sup.6 roentgens per hour, and the resulting polymer is worked into a contact lens by a suitable forming process involving cutting, grinding and polishing operations.
    Type: Grant
    Filed: July 16, 1986
    Date of Patent: June 13, 1989
    Assignees: Japan Atomic Energy Research Institute, Tokyo Contact Lens Research Institute
    Inventors: Isao Kaetsu, Minoru Kumakura, Hidenari Suyama, Nobuo Kameda, Hideo Koyama
  • Patent number: 4800085
    Abstract: A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl- tyrosyl-D-leucyl-leucyl-arginyl-proline ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.
    Type: Grant
    Filed: November 20, 1986
    Date of Patent: January 24, 1989
    Assignees: Japan Atomic Energy Research Institute, Keizo Shida, Takeda Chemical Indus. Ltd.
    Inventors: Masaru Yoshida, Masaharu Asano, Isao Kaetsu, Katsuyuki Nakai, Hidetoshi Yamanaka, Keizo Shida, Akira Shiraishi
  • Patent number: 4769082
    Abstract: The efficiency of enzymatic saccharification and fermentation of cellulose in a waste cellulose resource can be increased by a preliminary treatment with ionizing radiation. This irradiation of the waste cellulose resource can be accelerated by the preliminary addition of an aqueous alkali solution.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: September 6, 1988
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Minoru Kumakura, Noboru Kasai, Masao Tamada, Isao Kaetsu
  • Patent number: 4652443
    Abstract: A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl-tyrosyl-D-leucyl-leucyl-arginyl-pro line ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.
    Type: Grant
    Filed: May 22, 1984
    Date of Patent: March 24, 1987
    Assignees: Japan Atomic Energy Research Institute, Keizo Shida, Takeda Chemical Industries, Ltd.
    Inventors: Masaru Yoshida, Masaharu Asano, Isao Kaetsu, Katsuyuki Nakai, Hidetoshi Yamanaka, Keizo Shida, Akira Shiraishi
  • Patent number: 4584136
    Abstract: An Estracyt compound having a carcinostatic bound thereto is obtained by reacting an Estracyt compound with a carcinostatic having one or more radicals selected from among COOH, Cl, NH.sub.2 and OH, either directly or after reaction with an amine to replace one or both Cl groups in the nitrogen mustard portion in the Estracyt compound with a NH.sub.2 group, in the presence or absence of a catalyst. The resulting compound is more effective in cancer control than the Estracyt compound associated substance.
    Type: Grant
    Filed: March 1, 1985
    Date of Patent: April 22, 1986
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Masaru Yoshida, Masaharu Asano, Isao Kaetsu, Hidetoshi Yamanaka, Katsuyuki Nakai, Hisako Yuasa, Keizo Shida
  • Patent number: 4582719
    Abstract: A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: April 15, 1986
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Masaharu Asano, Minoru Kumakura, Masaru Yoshida
  • Patent number: 4552633
    Abstract: A fine particulate carrier for use in clinical testing which has a size of 0.5 to 20 microns and a process for producing thereof are herein disclosed.
    Type: Grant
    Filed: September 22, 1983
    Date of Patent: November 12, 1985
    Assignees: Japan Atomic Energy Research Institute, Japan Immunoresearch Laboratories Co., Ltd.
    Inventors: Minoru Kumakura, Isao Kaetsu, Mieko Suzuki, Masakazu Adachi
  • Patent number: 4483807
    Abstract: A process is herein disclosed for producing a slow release composite comprising grinding and mixing mechanically in a frozen state one or more polypeptides, one or more proteins and one or more physiologically active substances shaping the blend into a desired form and compressing at a pressure of from 100 to 20,000 kg/cm.sup.2 to thereby produce a slow release composite having the physiologically active substances encapsulated therein.
    Type: Grant
    Filed: January 20, 1982
    Date of Patent: November 20, 1984
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Masaharu Asano, Masaru Yoshida, Isao Kaetsu
  • Patent number: 4411754
    Abstract: A polymer composition containing a physiologically active substance which can be released at a controlled rate is prepared by contacting one or more polymerizable monomers with the physiologically active substance, making the monomers into a specific shape and then irradiating the shaped article with light or an ionizing radiation at a low temperature below room temperature to polymerize the polymerizable monomers.
    Type: Grant
    Filed: February 13, 1981
    Date of Patent: October 25, 1983
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Masaru Yoshida, Minoru Kumakura
  • Patent number: 4379038
    Abstract: A physiologically active substance controlled release composite composition is prepared by a process which comprises the steps of:adding a physiologically active substance to a physiologically active substance-containing adsorbent previously prepared by adsorbing the same or a different physiologically active substance onto an inorganic adsorbent, and dispersing and mixing;dispersing the resulting mixture in a polymerizable vinyl monomer containing 0 to 50% of synthetic high molecular weight subtance which is polymerizable at a temperature of below -20.degree. C.; and,after holding the desired shape, irradiating the resulting dispersion with an ionizing radiation at a temperature of -20.degree. to -100.degree. C. to polymerize.
    Type: Grant
    Filed: September 19, 1980
    Date of Patent: April 5, 1983
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Masaru Yoshida
  • Patent number: 4359483
    Abstract: A process is herein disclosed for producing a multi-layered slow release composite comprising: a first step wherein one or more physiologically active substances is mixed with one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof, and the mixture is given a predetermined shape and subjected to a physical treatment to form a slow release composite; a second step wherein a predetermined thickness of coating of one member selected from the group consisting of one or more supercooling polymerizable vinyl monomers, one or more natural or synthetic polymeric substances and a mixture thereof is formed on the surface of said slow release composite, which then is subjected to a physical treatment so that a layer wherein no physiologically active substance is encapsulated is formed on the surface of said slow release composite; a third step wherein a predetermined thickness of coating of a mixtu
    Type: Grant
    Filed: February 10, 1981
    Date of Patent: November 16, 1982
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Masaru Yoshida
  • Patent number: 4321117
    Abstract: A polymer composition containing a physiologically active substance which can be released at a controlled rate is prepared by contacting one or more polymerizable monomers with the physiologically active substance, mking the monomers into a specific shape and then irradiating the shaped article with light or an ionizing radiation at a low temperature below room temperature to polymerize the polymerizable monomers.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: March 23, 1982
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Masaru Yoshida, Minoru Kumakura
  • Patent number: 4311732
    Abstract: In accordance with this invention, there is provided a primer composition prepared by dissolving in an organic solvent at least one diepoxy compound selected from the group consisting of:(1) polyalkylene glycol diglycidyl ether of the formula; ##STR1## (2) poly(alkylene glycol) diglycidyl ether of the formula; ##STR2## and (3) diepoxide derived from a bisphenol of the formula; (wherein R.sub.1 is a linear or branched alkylene group having less than 8 carbon atoms; R.sub.2 is a linear or branched alkyl group having less than 4 carbon atoms, R.sub.3 is a linear or branched alkylene group having less than 8 carbon atoms, or a binding group selected from the class consisting of ##STR3## l, m and n are each an integer of from 0 to less than 10, the sum of l and m being more than 1).Also in accordance with the invention, there is provided a process for producing a coated product using such primer composition.
    Type: Grant
    Filed: June 5, 1979
    Date of Patent: January 19, 1982
    Assignees: Mitsubishi Gas Chemical Company Inc., Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Minoru Kumakura, Masaru Yoshida, Goro Shimaoka, Masanobu Urabe
  • Patent number: 4310397
    Abstract: A polymer composition containing a physiologically active substance and being capable of releasing it at a controlled rate can be prepared by contacting 10 parts, by weight, of one or more polymerizable monomers and 0.1 to 30 parts, by weight, of one or more physiologically active substances and irradiating them with light or an ionizing radiation while maintaining the system in an anhydrous condition and in airless state.
    Type: Grant
    Filed: February 12, 1980
    Date of Patent: January 12, 1982
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Masaru Yoshida, Masaharu Asano
  • Patent number: 4272617
    Abstract: Enzymes and/or bacteria cells are immobilized by forming an aqueous mixture of enzymes and/or bacteria cells and a hydrophobic, vitrifiable monomer in an amount of at least 76% by weight of all monomers present, and irradiating the mixture by means of ionizing radiation at a temperature less than -10.degree. C. to polymerize the monomer.
    Type: Grant
    Filed: July 26, 1979
    Date of Patent: June 9, 1981
    Assignee: Japan Atomic Energy Research Institute
    Inventors: Isao Kaetsu, Minoru Kumakura, Masaru Yoshida