Abstract: The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.

Abstract: Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##

Abstract: Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

Abstract: Compounds of formula (I): ##STR1## (wherein n is 0, 1 or 2 and R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, X, Y and Z are a variety of groups and atoms) have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment or prophylaxis of thrombotic conditions.

Abstract: Novel physiologically active substances KS-501 and KS-502 having inhibitory activity on serotonin release from platelets and/or platelet aggregation are produced by culturing a microorganism of the genus Sporothrix.

Abstract: Carbapenem derivatives useful as antibacterial agents have the formula ##STR1## wherein: X represents a hydrogen atom or a methyl group; andY represents a group of the formula: ##STR2## in which: Z represents an oxygen atom or two hydrogen atoms;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a C.sub.1-4 alkanoyl group, or a C.sub.1-4 alkanesulfonyl group;R.sup.2 represents a hydrogen atom or a hydroxy group, and R.sup.3 represents a carbamoyl group; orR.sup.2 represents a carbamoyloxy group, and R.sup.3 represents a hydrogen atom or a carbamoyl group;R.sup.4 represents a hydrogen atom or a C.sub.1-4 alkyl group; and ##STR3## represents a 4-6 membered saturated heterocyclic group in which the indicated nitrogen atom is the only hetero-atom;or a pharmaceutically acceptable salt or ester thereof.

Abstract: A new substance K-259-2 having a molecular formula of C.sub.21 H.sub.18 O.sub.7, a molecular weight of 382 and an elemental analysis (%) of H: 4.50, C: 65.53 and N: 0. This substance is of interest in providing a new vasodilating agent in view of its ability to dilate the blood vessel, particularly the artery, of mammals. This substance may be obtained by fermentation of a microorganism Micromonospora sp. K-259 (FERM BP 569).

Abstract: Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.

Abstract: Phenazine compounds represented by the formula: ##STR1## wherein R is a hydrogen atom, an unsubstituted or substituted lower alkanoyl group, or an unsubstituted or substituted arylcarbonyl group have antibacterial and anti-tumor activities.Some of these compounds are produced by incubation of a microorganism.

Abstract: Disclosed is a novel physiologically active substance K-4 which has a hypotensive activity, a process production thereof and a pharmaceutical composition containing the same.

Abstract: Compounds of formula (I): ##STR1## [wherein: Q represents a .dbd.CH-- group or a nitrogen atom;R.sup.1 represents a methylene group, a group of formula--CH.sub.2 CH(R.sup.3)--OCH.sub.2 --(R.sup.3 being a substituted or unsubstituted phenyl group) or a group of formula--(CH.sub.2).sub.n --CH(R.sup.4)--O--(n being 1 or 2 and R.sup.4 being a substituted or unsubstituted phenyl or phenylalkyl group); andA represents a group of formula--OR.sup.2(R.sup.2 being an alkenyl group, an alkynyl group or a substituted or unsubstituted alkyl or phenyl group) or a group of formula--CH.sub.2 --XR.sup.11(X being an oxygen or sulphur atom and R.sup.11 being an aryl or aralkyl group or, when X represents an oxygen atom, R.sup.11 being a hydrogen atom or a carbonyloxy or sulphonyloxy group) andacid addition salts and metal complexes thereof are valuable antimicrobial agents having low toxicity to humans and other animals and are especially valuable for the eradication of fungi.

Abstract: The antibacterial compounds 7-deazaadenosine and 7-deazinosine are produced by fermentation of a new microorganism of the genus Micromonospora. At least one of the active substances is isolated from the culture medium.

Abstract: A novel antibacterial compound, XK-99, is produced by fermentation of an organism belonging to the genus Micromonospora. The compound is isolated from the microbial cells and culture liquor.

Abstract: The antibiotic XK-62-2 is produced by fermentation of microorganisms belonging to the genus Micromonospora. The antibiotic is accumulated in the culture liquor and is isolated therefrom.

Abstract: A novel series of antibiotics designated the XK-88 series are produced by culturing a microorganism belonging to the genus Streptomyces in a nutrient medium and thereafter recovering the antibiotics from the culture liquor.

Abstract: A new antibiotic, Fortimicin A, is produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotic is accumulated in the culture medium and is isolated therefrom.

Abstract: Substances of the structure ##EQU1## wherein Z is phosphorus, X.sup.-is Cl.sup.-, Br.sup.-, ClO.sub.2 .sup.- or BF.sub.4 .sup.-, and R.sub.1 - R.sub.4 are alkyl or aromatic groups are excellent inhibitors of fog formation when incorporated in photographic emulsions containing silver halides.

Abstract: A novel series of antibiotics designated the XK-88 series are produced by culturing a microorganism belonging to the genus Streptomyces in a nutrient medium and thereafter recovering the antibiotics from the culture liquor.BACKGROUND OF THE INVENTIONThe present invention relatees to novel antibiotics and a process for the production thereof. More specifically the present invention relates to novel antibiotics designated, XK-88-1, XK-88-2, XK-88-3 and XK-88-5 and a process for producing such antibiotics.Antibiotics which exhibit activity against a borad spectrum of bacteria are always in demand. To this end, a new species of microorganism has been isolated from soil located in Tajima-cho, Hofu-shi, Yamaguchi-ken, Japan. This new species, when cultured, produces a series of new antibiotics, the XK-88 series, all of which exhibit strong antibacterial activity against various Gram-positive and Gram-negative bacteria.

Abstract: A new antibiotic, Fortimicin B, is produced by fermentation of a microorganism belonging to the genus Micromonospora. The antibiotic is accumulated in the culture medium and is isolated therefrom.