Patents by Inventor Isao Kohno

Isao Kohno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10183007
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 22, 2019
    Assignees: Usien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd., Nagasaki University
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Publication number: 20160151329
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 2, 2016
    Applicants: Nagasaki University, Usaien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd.
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Patent number: 9090672
    Abstract: Disclosed is a method for producing an antibody directed against a protein, particularly a transmembrane protein, expressed on the surfaces of cells. Specifically disclosed is a means for obtaining a desired antibody by mixing cells capable of expressing an antigen protein on the surfaces thereof (i.e., antigen molecule-expressing cells) with an antibody library composed of antibody-expressing cells, viruses or the like, and subsequently concentrating/isolating only components (e.g., antibody-expressing cells, viruses) capable of binding to the antigen molecule-expressing cells from the components (e.g., antibody-expressing cells, viruses) of the antibody library.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: July 28, 2015
    Assignee: CHIOME BIOSCIENCE INC.
    Inventors: Shu-ichi Hashimoto, Donghui Li, Shoko Ishida, Hidetaka Seo, Chika Koyama, Yukiko Banzai, Naoto Harigai, Isao Kohno
  • Patent number: 8273859
    Abstract: The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for pancreatic cancer containing an anti-AMIGO2 antibody.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: September 25, 2012
    Assignees: Perseus Proteomics Inc., The University of Tokyo
    Inventors: Hiroyuki Aburatani, Hiroko Iwanari, Isao Kohno
  • Patent number: 8211630
    Abstract: The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for pancreatic cancer containing an anti-AMIGO2 antibody.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: July 3, 2012
    Assignees: Perseus Proteomics Inc., The University of Tokyo
    Inventors: Hiroyuki Aburatani, Hiroko Iwanari, Isao Kohno
  • Publication number: 20110306126
    Abstract: Disclosed is a method for producing an antibody directed against a protein, particularly a transmembrane protein, expressed on the surfaces of cells. Specifically disclosed is a means for obtaining a desired antibody by mixing cells capable of expressing an antigen protein on the surfaces thereof (i.e., antigen molecule-expressing cells) with an antibody library composed of antibody-expressing cells, viruses or the like, and subsequently concentrating/isolating only components (e.g., antibody-expressing cells, viruses) capable of binding to the antigen molecule-expressing cells from the components (e.g., antibody-expressing cells, viruses) of the antibody library.
    Type: Application
    Filed: December 7, 2009
    Publication date: December 15, 2011
    Applicant: CHIOME BIOSCIENCE INC.
    Inventors: Shu-ichi Hashimoto, Donghui LI, Shoko Ishida, Hidetaka Seo, Chika Koyama, Yukiko Banzai, Naoto Harigai, Isao Kohno
  • Publication number: 20110288278
    Abstract: The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for pancreatic cancer containing an anti-AMIGO2 antibody.
    Type: Application
    Filed: July 14, 2011
    Publication date: November 24, 2011
    Applicants: The University of Tokyo, Perseus Proteomics Inc.
    Inventors: Hiroyuki Aburatani, Hiroko Iwanari, Isao Kohno
  • Patent number: 7955807
    Abstract: To provide a method of determining vasculopathy, which is a risk factor of myocardial infarction, angiopathic dementia, etc., at an early stage thereof (i.e., mild vasculopathy). The present invention provides a method of determining the severity of mild vasculopathy, including determining PTX3 level in an assay sample by use of an anti-PTX3 monoclonal antibody.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: June 7, 2011
    Assignees: The University of Tokyo, Perseus Proteomics Inc.
    Inventors: Tatsuhiko Kodama, Takao Hamakubo, Koji Maemura, Akira Sugiyama, Hiroko Iwanari, Isao Kohno, Yukio Ito
  • Patent number: 7875705
    Abstract: It is an object of the present invention to provide a novel antibody capable of specifically recognizing ROBO1 that is expressed in a cell membrane, a hybridoma that produces the above antibody, a method for producing the above antibody, and a tumor diagnostic agent used in PET comprising the above antibody. The present invention provides a monoclonal antibody capable of specifically recognizing ROBO1 existing on the surface of a cell, which is obtained by immunizing an animal to be immunized with a ROBO1-displaying budded baculovirus recovered from the culture supernatant of host cells infected with a recombinant baculovirus comprising the full-length cDNA of ROBO1 as an antigen.
    Type: Grant
    Filed: November 28, 2007
    Date of Patent: January 25, 2011
    Assignees: The University of Tokyo, Perseus Proteomics Inc.
    Inventors: Hiroko Iwanari, Isao Kohno, Takao Hamakubo, Yoshitaka Kumakura, Hirotaka Itoh, Toshiko Sakihama, Hiroyuki Aburatani, Toshimitsu Momose
  • Publication number: 20100316568
    Abstract: The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for pancreatic cancer containing an anti-AMIGO2 antibody.
    Type: Application
    Filed: April 18, 2007
    Publication date: December 16, 2010
    Applicants: Perseus Proteomics Inc., The University of Tokyo
    Inventors: Hiroyuki Aburatani, Hiroko Iwanari, Isao Kohno
  • Publication number: 20100062449
    Abstract: To provide a method of determining vasculopathy, which is a risk factor of myocardial infarction, angiopathic dementia, etc., at an early stage thereof (i.e., mild vasculopathy). The present invention provides a method of determining the severity of mild vasculopathy, including determining PTX3 level in an assay sample by use of an anti-PTX3 monoclonal antibody.
    Type: Application
    Filed: November 10, 2006
    Publication date: March 11, 2010
    Applicants: The University of Tokyo, Perseus Proteomics Inc.
    Inventors: Tatsuhiko Kodama, Takao Hamakubo, Koji Maemura, Akira Sugiyama, Hiroko Iwanari, Isao Kohno, Yukio Ito
  • Publication number: 20090092544
    Abstract: It is an object of the present invention to provide a novel antibody capable of specifically recognizing ROBO1 that is expressed in a cell membrane, a hybridoma that produces the above antibody, a method for producing the above antibody, and a tumor diagnostic agent used in PET comprising the above antibody. The present invention provides a monoclonal antibody capable of specifically recognizing ROBO1 existing on the surface of a cell, which is obtained by immunizing an animal to be immunized with a ROBO1-displaying budded baculovirus recovered from the culture supernatant of host cells infected with a recombinant baculovirus comprising the full-length cDNA of ROBO1 as an antigen.
    Type: Application
    Filed: November 28, 2007
    Publication date: April 9, 2009
    Applicants: THE UNIVERSITY OF TOKYO, PERSEUS PROTEOMICS INC.
    Inventors: Hiroko Iwanari, Isao Kohno, Takao Hamakubo, Yoshitaka Kumakura, Hirotaka Itoh, Toshiko Sakihama, Hiroyuki Aburatani, Toshimitsu Momose
  • Publication number: 20090047305
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded, and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Application
    Filed: February 24, 2006
    Publication date: February 19, 2009
    Applicants: NAGASAKI UNIVERSITY, USAIEN PHARMACEUTICAL CO., LTD., AMINO UP CHEMICAL CO., LTD.
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Patent number: 7294750
    Abstract: An absorptive wound covering protecting material and a method for preparing an absorptive wound covering protecting material are characterized by solidifying a sponge raw solution containing no reinforcement that is obtained by mixing viscose and crystalline mirabilite as main raw materials, or a sponge raw solution obtained by mixing viscose containing a reinforcement comprising natural fibers having a length of at least 5 mm to 40 mm, and crystalline mirabilite as main raw materials, by performing a heat treatment on the sponge raw solution, and then forming the solidified cellulose sponge in a thickness somewhat greater than a desired thickness, and then forming the cellulose sponge in a sheet form having a desired thickness by compressing the cellulose sponge, and, if required, carboxymethylating hydroxyl groups in a glucose unit constituting a cellulose sponge so that a degree of substitution of the hydroxyl groups is from 0.5 to less than 1.0, and then, forming an incision the cellulose sponge.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: November 13, 2007
    Assignee: Hogy Medical Co., Ltd.
    Inventors: Kumiko Taniguchi, Isao Kohno, Koji Tanabe, Yoshio Jo, Isao Ohnishi, Keisuke Kosake, Yuri Koyama
  • Publication number: 20040039322
    Abstract: The object is to provide an absorptive wound covering protecting material and a method for preparing the same which is quite excellent in an absorptiveness and a liquid-holding property, and is superior in shape-maintaining ability and strength, and wherein a reinforcement can be used and workability is improved, as well as a hemostatic wound healing effect can be enhanced, compared to an absorptive wound covering protecting material comprising a thinly solidified cellulose sponge.
    Type: Application
    Filed: March 14, 2003
    Publication date: February 26, 2004
    Inventors: Kumiko Taniguchi, Isao Kohno, Koji Tanabe, Yoshio Jo, Isao Ohnishi, Keisuke Kosake, Yuri Koyama
  • Patent number: 6132719
    Abstract: A monoclonal antibody which specifically reacts with D-monomer produced by digesting human fibrinogen with granulocyte elastase and D-domain containing digestion products produced by digesting human stabilized fibrin with granulocyte elastase, but does not react with fibrinogen, or fragment X, Y or E produced by digesting fibrinogen with granulocyte elastase is disclosed. The D-dimer or DD/E complex produced by digestion with granulocyte elastase in a sample from a living body can be analyzed without being interferred with fibrinogen, digestion products of fibrinogen with plasmin, or digestion products of stabilized fibrin with plasmin, using the monoclonal antibody.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: October 17, 2000
    Assignee: Iatron Laboratories, Inc.
    Inventors: Isao Kohno, Kimiko Inuzuka, Yumiko Ito, Ken Fukushi
  • Patent number: 5888749
    Abstract: A first monoclonal antibody which specifically reacts with a human .alpha..sub.2 -plasmin inhibitor complex (PIC) and a human plasminogen; a second monoclonal antibody which reacts with PIC and also with a human .alpha..sub.2 -plasmin inhibitor; a third monoclonal antibody which reacts with PIC, but does not react with a human plasminogen and a human .alpha..sub.2 -plasmin inhibitor; hybridomas which secrete the first to third monoclonal antibodies, and an immunoassay using the first to third monoclonal antibodies.
    Type: Grant
    Filed: September 21, 1992
    Date of Patent: March 30, 1999
    Assignee: Iatron Laboratories, Inc.
    Inventors: Gilbu Soe, Isao Kohno, Mami Shiiba
  • Patent number: 5821068
    Abstract: A monoclonal antibody that reacts with a human soluble fibrin but not with a human fibrinogen; a hybridoma that secretes the above antibody; and a method of assaying a human soluble fibrin with the above antibody. It is possible to determine the amount of soluble fibrin in the plasma of a patient specifically, readily and rapidly by agglutination and EIA without being affected by plasma fibrinogen, plasmin-degradation product of fibrinogen, fibrin fragment, and plasmin-degradation product of stabilized fibrin even without pretreating the plasma sample.
    Type: Grant
    Filed: September 22, 1995
    Date of Patent: October 13, 1998
    Assignee: Iatron Laboratories, Inc.
    Inventors: Gilbu Soe, Isao Kohno, Kimiko Inuzuka, Yumiko Ito
  • Patent number: 5500345
    Abstract: Monoclonal antibodies specifically reacting with the side face of a C-reactive protein (CRP), i.e., monoclonal antibodies specifically reacting with the side face of a disk-like subunit of a C-reactive protein (CRP), hybridoma producing the monoclonal antibody, and methods for the use thereof are disclosed.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: March 19, 1996
    Assignee: Iatron Laboratories, Inc.
    Inventors: Gilbu Soe, Isao Kohno, Michiyo Tanaka
  • Patent number: 5203231
    Abstract: An output shaft is a hollow shaft and passes through a gearbox. Holes for mounting also pass through the gearbox. The holes are located at the vertexes of a square or rectangle. And the output shaft, which is displaced (offset) relative to the square's (or rectangle's) center, is located on one diagonal of the square. This structure provides a variety of possibilities of assembling the gear device with a big motor, and the amount of projection of the faces of the gearbox from the output shaft can be kept as small as possible.
    Type: Grant
    Filed: January 30, 1992
    Date of Patent: April 20, 1993
    Assignee: Sumitomo Heavy Industries, Ltd.
    Inventors: Kiyoji Minegishi, Isao Kohno, Tetsushi Isozaki, Katsumi Taki