Abstract: A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): with an organic boron compound of the formula (2): at 70° C. or below in the presence of a nickel catalyst and a base. The biaryl compounds produced using this process possess a high optical purity and are useful as intermediates for medicaments, agrochemicals, etc.

Abstract: A method for producing (S)—N-protected-propargylglycine of the following formula (2), wherein the method comprises asymmetrically hydrolyzing an N-protected-propargylglycine ester of the following formula (1) by using an asymmetric hydrolysis enzyme or a cultured substance of a microorganism having an ability of producing this enzyme or a treated substance thereof. The hydrolysis enzyme is obtained from a microorganism selected from the group consisting of Thermomyces genus, Aspergillus genus, Rhizopus genus, Penicillium genus, Pseudomonas genus, Humicola genus, Burkholderia genus, Candida genus Bacillus genus and Streptomyces genus.

Abstract: A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): with an organic boron compound of the formula (2): at 70° C. or below in the presence of a nickel catalyst and a base. The biaryl compounds produced using this process possess a high optical purity and are useful as intermediates for medicaments, agrochemicals, etc.

Abstract: A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): with an organic boron compound of the formula (2): at 70° C. or below in the presence of a nickel catalyst and a base. The biaryl compounds produced using this process possess a high optical purity and are useful as intermediates for medicaments, agrochemicals, etc.

Abstract: A method for producing (S)-N-protected-propargylglycine of the following formula (2), wherein the method comprises asymmetrically hydrolyzing an N-protected-propargylglycine ester of the following formula (1) by using the following asymmetric hydrolysis enzyme or a cultured substance of a microorganism having an ability of producing this enzyme or a treated substance thereof. [Asymmetric Hydrolysis Enzyme] Hydrolysis enzymes derived from a microorganism selected from the group consisting of Thermomyces genus, Aspergillus genus, Rhizopus genus, Penicillium genus, Pseudomonas genus, Humicola genus, Burkholderia genus, Candida genus and Streptomyces genus.

Abstract: There is provided a production method for producing a biarylalanine compound of formula (4): wherein R1 represents a amino protective group and R2 represents an amino protective group or a hydrogen atom, R3 is a carboxy protective group, or the like, and R4 is a substituted or unsubstituted aryl or heteroaryl group, characterized by reacting an aromatic amino acid of formula (1) wherein X is a halogen atom or a trifluoromethanesulfonyloxy group, and R1, R2 and R3 has the same meaning as defined above, with an organic boron compound of formula (2): wherein R4 has the same meaning as defined above, and Q1 and Q2 are the same or different and each is a hydroxy group, an alkoxy group having 1 to 4 carbon atom(s), in the presence of nickel catalyst and a base.

Abstract: There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p??(1) wherein R1, R2 and Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2); R1COOH??(2) wherein R1 denotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3); (R2)pY(O)nX??(3) wherein R2 denotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.

Abstract: There are disclosed imine compounds of formula (7) and (11), and processes for preparing the same:

Abstract: There is disclosed an advantageous mixed acid anhydride production method of formula (1):

Abstract: In an incombustible duct hose, a cloth material with a predetermined width is spirally wound to form a cylindrical shape, and a metal strip-like material caulks adjacent side edge portions of the spirally-wound cloth material to connect them. The cloth material is fabricated in a gas impermeable state by coating a silicone at least on one surface of a silica cloth sheet so that a texture of the silica cloth sheet is clogged by the coated silicone. The silicone is subjected to a fire retardant treatment by mixing a flame retardant.

Abstract: A process for preparing an optically active biaryl compound the formula (4): 1

Abstract: There is disclosed an advantageous mixed acid anhydride production method of formula (1): R1C(O)OY(O)n(R2)p  (1) wherein R1, R2 and Y denote the same as defined below, n and p denote an integer of 1 or 2, which is characterized by adding a carboxylic acid of formula (2); R1COOH  (2) wherein R1 denotes a hydrogen atom, an optionally substituted alkyl group or the like, an organic base to a solution of a carboxylic acid activating agent of formula (3); (R2)pY(O)nX  (3) wherein R2 denotes an optionally substituted aliphatic hydrocarbyl group or the like, Y denotes a carbon atom, a phosphorus atom, or a sulfur atom, and X denotes a chlorine atom or the like.

Abstract: There is provided a production method for producing a biarylalanine compound of formula (4): 1

Abstract: There are disclosed imine compounds of formula (7) and (11), and processes for preparing the same: 1

Abstract: A flexible hose having air-permeability is formed by either: sandwiching an air-permeable tape between tape end edge portions, as leading and trailing in a hose longitudinal direction, of a soft resin tape that is helically wound integrally with the air-permeable tape; or by helically winding only an air-permeable tape. The flexible hose can be properly used as a cleaner hose of a discharge circulation type by using it as an outer tube of a double tube structure. By providing lubricating properties to an inner circumference of the outer tube or an outer circumference of the inner tube, it is possible to prevent wear which might otherwise be caused by rubbing contact between the inner tube and outer tube.

Abstract: There are disclosed are A diastereomer salt of formula (1): a process for producing the same, a process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid of formula (2′): a novel optically active amine compound of formula (4): a novel optically active amine compound of formula (8): an imine compound of formula (7) or (11):

Abstract: An excellent laminate applicable to various uses capable of overcoming drawbacks of a foamed polyethylene resin such as weak wear resistance and weak strength, by effectively covering the surface of the foamed polyethylene resin, in which a resin layer containing a graft copolymer of an ethylene-vinyl acetate copolymer resin and a vinyl chloride resin is laminated to a foamed polyethylene resin, and a resin layer containing a graft copolymer of an ethylene-vinyl acetate copolymer resin and a vinyl chloride resin is interposed between the foamed polyethylene resin layer and the vinyl chloride resin layer.

Abstract: A process for producing a 2-alkylidene-4-bromoacetoacetic acid ester of the formula (3): wherein R1 and R2 each independently represent a lower alkyl group having 1-5 carbon atoms, the process is characterized by reacting a 4-bromoacetoacetic acid ester of the formula (1): where R1 has the same meaning as defined above, with an aldehyde of the formula (2): R2CHO  (2) wherein R2 has the same meaning as defined above, in an inert organic solvent in the presence of an amine and a carboxylic acid.

Abstract: There are disclosed are

Abstract: There is disclosed a process for producing an acid salt of a (Z)-2-aminothiazole compound of the formula (I): wherein R1 and R2 independently represent an alkyl group having 1 to 5 carbon atoms, Y represents a halogen atom, —OSO3H or —OPO(OH)2, m indicates the valence number of an inorganic acid of the formula: HY wherein Y represents the same as defined above, and n indicates an integer of 1 or 2, which process is characterized by: reacting an acid salt of a 2-aminothiazole compound of the formula (II): wherein R1 and R2 independently represent an alkyl group having 1 to 5 carbon atoms, X represents a bromine atom or an iodine atom, and the wavy line means that this compound is a mixture of the E- and Z-isomers, with the inorganic acid of the formula HY.