Patents by Inventor Isao Nagaoka

Isao Nagaoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10195271
    Abstract: The present invention addresses the problem of providing an antibody titer-increasing agent, such as an adjuvant, capable of sustaining an effect achieved by, for example, vaccination, which is an antibody titer-increasing agent such as an adjuvant that is safe, convenient and economical and can be easily taken irrespective of age, and a method for manufacturing the same. A method for increasing an antibody titer and a method for enhancing the effect of a vaccine, each method comprising using Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof; and an antibody titer-increasing agent such as an adjuvant that comprises Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: February 5, 2019
    Assignee: Meiji Co., Ltd.
    Inventors: Seiya Makino, Jun Henmi, Hiroshi Kano, Yukio Asami, Shuji Ikegami, Hiroyuki Itou, Yoshio Suzuki, Sachio Kawai, Keisuke Sawaki, Ko Okumura, Isao Nagaoka, Kazuyoshi Takeda
  • Publication number: 20160206733
    Abstract: The present invention addresses the problem of providing an antibody titer-increasing agent, such as an adjuvant, capable of sustaining an effect achieved by, for example, vaccination, which is an antibody titer-increasing agent such as an adjuvant that is safe, convenient and economical and can be easily taken irrespective of age, and a method for manufacturing the same. A method for increasing an antibody titer and a method for enhancing the effect of a vaccine, each method comprising using Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof; and an antibody titer-increasing agent such as an adjuvant that comprises Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof.
    Type: Application
    Filed: August 26, 2014
    Publication date: July 21, 2016
    Applicant: Meiji Co., Ltd.
    Inventors: Seiya Makino, Jun Henmi, Hiroshi Kano, Yukio Asami, Shuji Ikegami, Hiroyuki Itou, Yoshio Suzuki, Sachio Kawai, Keisuke Sawaki, Yasushi Okumura, Isao Nagaoka, Kazuyoshi Takeda
  • Patent number: 8242082
    Abstract: The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient.
    Type: Grant
    Filed: April 16, 2008
    Date of Patent: August 14, 2012
    Assignee: Seikagaku Corporation
    Inventors: Isao Nagaoka, Daiju Okuda, Shin Yomogida, Hiroshi Tamura
  • Publication number: 20090149632
    Abstract: The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient.
    Type: Application
    Filed: April 16, 2008
    Publication date: June 11, 2009
    Inventors: Isao Nagaoka, Daiju Okuda, Shin Yomogida, Hiroshi Tamura
  • Patent number: 7452856
    Abstract: The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: November 18, 2008
    Assignees: Seikagaku Corporation, Juntendo University
    Inventors: Isao Nagaoka, Daiju Okuda, Shin Yomogida, Hiroshi Tamura
  • Publication number: 20060009374
    Abstract: The present invention provides a novel peptide based on CAP11 as well as provides an antibacterial agent, an LPS-cell-binding inhibitor, and a drug such as a bacterial-infection-treating agent or an endotoxin-shock suppressant, each containing the peptide as an active ingredient. The peptide has the following amino acid sequence (SEQ ID NO: 1): X01 X02 X03 X03 X04 X02 X03 X03 X05 X04 X03 X04 X02 X01 X03 X02 X05 X03 (wherein X01 represents a cationic amino acid residue or a polar uncharged amino acid residue, X02 represents a non-polar amino acid residue, X03 represents a cationic amino acid residue, X04 represents a non-polar amino acid residue or a cationic amino acid residue, and X05 represents a non-polar amino acid residue or a polar uncharged amino acid residue). Each of the antibacterial agent, lipopolysaccharide-cell-binding inhibitor, and drug (e.g., bacterial-infection-treating agent or endotoxin-shock suppressant) contains the peptide as an active ingredient.
    Type: Application
    Filed: March 29, 2005
    Publication date: January 12, 2006
    Inventors: Isao Nagaoka, Daiju Okuda, Shin Yomogida, Hiroshi Tamura
  • Patent number: 6627621
    Abstract: Glucosamine salts are effective for the inhibition of neutrophil functions, and hence, are useful for the prevention and/or treatment of diseases, caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, such as respiratory disease syndrome and adult respiratory disease syndrome. Use of glucosamine salts can, therefore, provide neutrophil function inhibitors, preventives and/or remedies for diseases caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, and also methods for the prevention and/or treatment of such diseases.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: September 30, 2003
    Assignee: Dainichieseika Color & Chemicals Mfg. Co., Ltd.
    Inventors: Isao Nagaoka, Koji Sakamoto
  • Publication number: 20020128230
    Abstract: Glucosamine salts are effective for the inhibition of neutrophil functions, and hence, are useful for the prevention and/or treatment of diseases, caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, such as respiratory disease syndrome and adult respiratory disease syndrome. Use of glucosamine salts can, therefore, provide neutrophil function inhibitors, preventives and/or remedies for diseases caused as a result of an excessive extracellular release of active oxygen and antibiotic proteins by neutrophils, and also methods for the prevention and/or treatment of such diseases.
    Type: Application
    Filed: July 18, 2001
    Publication date: September 12, 2002
    Applicant: Koyo Chemical Co., Ltd.
    Inventors: Isao Nagaoka, Koji Sakamoto
  • Patent number: 4542578
    Abstract: Mutually spaced apart TCO film portions are formed on a glass substrate. An amorphous silicon film of PIN junction type is formed to cover these TCO film portions, and an aluminum film is formed thereon. The aluminum film in the vicinity of the gap between adjacent TCO film portions is removed by means of a laser beam, and the amorphous silicon film is removed by reactive plasma etching using the aluminum film as a mask to thereby expose portions of the TCO film. An aluminum-titanium film is formed over the aluminum film and the exposed portions of the TCO film. The aluminum-titanium film is separated by means of a laser beam to form a plurality of photoelectric converting regions. The photoelectric converting regions thus formed on the glass substrate are connected in series.
    Type: Grant
    Filed: March 15, 1984
    Date of Patent: September 24, 1985
    Assignee: Sanyo Electric Co., Ltd.
    Inventors: Masaru Yamano, Isao Nagaoka, Yukinori Kuwano, Hiroshi Kawada, Souichi Sakai
  • Patent number: 4082817
    Abstract: A process for producing a maleic anhydride adduct of high molecular weight 1,2-polybutadiene by contacting with heat maleic anhydride with high molecular weight 1,2-polybutadiene in the absence of a radical initiator in a halogenated aromatic hydrocarbon solvent. The adduct obtained by this process has a high molecular weight of more than 10,000 and is quite free from gel. Said process enables the addition of maleic anhydride in any desired proportion.
    Type: Grant
    Filed: March 29, 1976
    Date of Patent: April 4, 1978
    Assignee: Japan Synthetic Rubber Co., Ltd.
    Inventors: Fumitake Imaizumi, Isao Nagaoka, Mitsuo Kurokawa, Koei Komatsu
  • Patent number: 4075096
    Abstract: A suction device for an oil separation tank mounted on a floating body comprises a liquid piping structure for transporting floating oil from the oil separation tank into a storage tank and a vacuum piping structure for always retaining floating oil in the oil separation tank at a suction state, and may automatically control an intermittent suction operation.
    Type: Grant
    Filed: September 16, 1976
    Date of Patent: February 21, 1978
    Assignee: Bridgestone Tire Company Limited
    Inventors: Hiroshi Kawakami, Yukio Tsukagawa, Isao Nagaoka
  • Patent number: 4049170
    Abstract: A device for pulling up and paying out an oil boom comprises a structural frame, a pair of end pulleys horizontally journaled on the frame, an endless belt engaged with the end pulleys and having a plurality of engaging projections for oil boom and a pusher member for slightly urging the oil boom against the endless belt, the pusher member being resiliently supported by a supporting member with a proper distance held between the bottom portion of the pusher member and the upper surface of the endless belt.
    Type: Grant
    Filed: April 23, 1976
    Date of Patent: September 20, 1977
    Assignee: Bridgestone Tire Company Limited
    Inventors: Hiroshi Kawakami, Isao Nagaoka, Yukio Tsukagawa
  • Patent number: 4023973
    Abstract: A photosensitive composition comprising (1) a maleic anhydride adduct of 1,2-polybutadiene having a molecular weight of 10,000 or higher, (2) at least one photosensitizer and/or at least one photosensitive crosslinking agent, and, if necessary, (3) at least one acrylic monomer. This composition can be developed with water or a polar solvent such as an alcohol, and its layer formed on a support provides a printing plate. When the acrylic monomer is contained, the composition is suitable for use in flexographic printing.
    Type: Grant
    Filed: April 17, 1975
    Date of Patent: May 17, 1977
    Assignee: Japan Synthetic Rubber Co., Ltd.
    Inventors: Fumitake Imaizumi, Isao Nagaoka, Mitsuo Kurokawa, Koei Komatsu, Yasuyuki Takimoto, Hidefumi Kusuda
  • Patent number: 3931136
    Abstract: High molecular weight cis-1,4-polyisoprene is produced by contacting isoprene with a catalyst formed by admixing (A) a titanium tetrachloride, (B) a trihydrocarbylaluminum and (C) a beta-diketone. The activity of this ternary catalyst is not adversely affected by such impurities as cyclopentadiene that are contained in the feed stock isoprene.
    Type: Grant
    Filed: May 23, 1974
    Date of Patent: January 6, 1976
    Assignee: Japan Synthetic Rubber Co., Ltd.
    Inventors: Kan Mori, Hiroharu Ikeda, Isao Nagaoka, Tooru Shibata, Sigeo Kawatani, Tatsuhiko Kikuchi