Patents by Inventor Isao Ohashi
Isao Ohashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230128195Abstract: The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof.Type: ApplicationFiled: November 23, 2022Publication date: April 27, 2023Applicants: President and Fellows of Harvard College, Eisai R&D Management Co., LTD.Inventors: Yoshito Kishi, Yanran Ai, Ning Ye, Qiaoyi Wang, Kenzo Yahata, Kentaro Iso, Santhosh Reddy Naini, Shuji Yamashita, Jihoon Lee, Isao Ohashi, Takashi Fukuyama
-
Patent number: 11548898Abstract: The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).Type: GrantFiled: July 6, 2018Date of Patent: January 10, 2023Assignees: President and Fellows of Harvard College, Eisai R&D Management Co., LTD.Inventors: Yoshito Kishi, Yanran Ai, Ning Ye, Qiaoyi Wang, Kenzo Yahata, Kentaro Iso, Santhosh Reddy Naini, Shuji Yamashita, Jihoon Lee, Isao Ohashi, Takashi Fukuyama
-
Publication number: 20210230177Abstract: The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof.Type: ApplicationFiled: July 6, 2018Publication date: July 29, 2021Applicants: President and Fellows of Harvard College, Eisai R&D Management Co., LTD.Inventors: Yoshito Kishi, Yanran Ai, Ning Ye, Qiaoyi Wang, Kenzo Yahata, Kentaro Iso, Santhosh Reddy Naini, Shuji Yamashita, Jihoon Lee, Isao Ohashi, Takashi Fukuyama
-
Patent number: 10450684Abstract: Disclosed is a sewing machine which evaluates sewing quality using a stitch tightness index. During sewing operation, a used length of an upper thread per stitch is detected, and a stitch tightness index per sewn stitch is calculated on the basis of a stitch length per stitch defined by sewing pattern data, a fabric thickness of a sewing workpiece, and detected data of the used length of the upper thread. Then, notification is made which corresponds to the calculated stitch tightness index per sewn stitch (such as a visual display of the stitch tightness index). After that, acceptability/non-acceptability of the thread tightness per sewn stitch can be determined by comparing the calculated stitch tightness index per sewn stitch against a reference value, and a result of the determination can be notified.Type: GrantFiled: February 23, 2016Date of Patent: October 22, 2019Assignees: TOKAI KOGYO MISHIN KABUSHIKI KAISHA, NSD CORPORATIONInventors: Isao Ohashi, Koichi Nakamura, Yoshichika Takizawa, Masayoshi Ono, Hirotsugu Uenishi
-
Patent number: 9934575Abstract: According to some aspects, an image processing apparatus is provided, comprising circuitry configured to receive an input image, the input image being supplied as a stereoscopic image including a left image for a left eye and a right image for a right eye, calculate depth information for each of a plurality of sub-regions of the input image based at least in part on the right image and the left image, and determine, for each of the plurality of sub-regions of the input image, at least one luminance component based at least in part on the depth information and a function indicating a relationship between depth information and luminance value.Type: GrantFiled: June 25, 2015Date of Patent: April 3, 2018Assignee: Sony CorporationInventors: Shuichi Takahashi, Takanori Ishikawa, Isao Ohashi, Satoshi Shioiri
-
Publication number: 20180016723Abstract: Disclosed is a sewing machine which evaluates sewing quality using a stitch tightness index. During sewing operation, a used length of an upper thread per stitch is detected, and a stitch tightness index per sewn stitch is calculated on the basis of a stitch length per stitch defined by sewing pattern data, a fabric thickness of a sewing workpiece, and detected data of the used length of the upper thread. Then, notification is made which corresponds to the calculated stitch tightness index per sewn stitch (such as a visual display of the stitch tightness index). After that, acceptability/non-acceptability of the thread tightness per sewn stitch can be determined by comparing the calculated stitch tightness index per sewn stitch against a reference value, and a result of the determination can be notified.Type: ApplicationFiled: February 23, 2016Publication date: January 18, 2018Inventors: Isao OHASHI, Koichi NAKAMURA, Yoshichika TAKIZAWA, Masayoshi ONO, Hirotsugu UENISHI
-
Patent number: 9609298Abstract: Disclosed herein are an imaging apparatus, an imaging method, a recording medium, and a program which are capable of processing imaging data in a manner similar to that of a normal frame rate. Image data captured by a solid-state imaging element capable of performing imaging at a high resolution and a high frame rate is supplied to a memory control. The memory control, at the same time as writing the imaging data input from the imaging element in a frame memory, reads preceding frames of imaging data that are recorded on the frame memory, and sequentially respectively outputs them in parallel, as video image data items, for each frame, to respective camera signal processing units. In the camera signal processing units, a video output, a viewfinder output, codec units, and recording units, processing similar to that when a frame rate that is ¼ the imaging frame rate is executed.Type: GrantFiled: June 5, 2015Date of Patent: March 28, 2017Assignee: SONY CORPORATIONInventors: Seiji Kobayashi, Isao Ohashi, Yoshihiko Kuroki
-
Publication number: 20150294475Abstract: According to some aspects, an image processing apparatus is provided, comprising circuitry configured to receive an input image, the input image being supplied as a stereoscopic image including a left image for a left eye and a right image for a right eye, calculate depth information for each of a plurality of sub-regions of the input image based at least in part on the right image and the left image, and determine, for each of the plurality of sub-regions of the input image, at least one luminance component based at least in part on the depth information and a function indicating a relationship between depth information and luminance value.Type: ApplicationFiled: June 25, 2015Publication date: October 15, 2015Applicant: Sony CorporationInventors: Shuichi Takahashi, Takanori Ishikawa, Isao Ohashi, Satoshi Shioiri
-
Patent number: 9098907Abstract: An image processing apparatus includes: a luminance extraction means to extract luminance components of an input image; a contrast extraction means to extract contrast components of the input image based on the luminance components of the input image extracted by the luminance extraction means; a storage means to store a performance function indicating relation between the contrast components of the input image and depth amounts subjectively perceived, which is determined based at least in part on visual sense characteristics of human beings; and a contrast adjustment means to calculate present depth amounts of the input image from the contrast components of the input image extracted by the contrast extraction means based at least in part on the performance function with respect to region of the input image which are determined from depth information of the input image and adjusting contrast components of the input image.Type: GrantFiled: January 9, 2014Date of Patent: August 4, 2015Assignee: Sony CorporationInventors: Shuichi Takahashi, Takanori Ishikawa, Isao Ohashi, Satoshi Shioiri
-
Patent number: 9071813Abstract: Disclosed herein are an imaging apparatus, an imaging method, a recording medium, and a program which are capable of processing imaging data in a manner similar to that of a normal frame rate. Image data captured by a solid-state imaging element capable of performing imaging at a high resolution and a high frame rate is supplied to a memory control. The memory control, at the same time as writing the imaging data input from the imaging element in a frame memory, reads preceding frames of imaging data that are recorded on the frame memory, and sequentially respectively outputs them in parallel, as video image data items, for each frame, to respective camera signal processing units. In the camera signal processing units, a video output, a viewfinder output, codec units, and recording units, processing similar to that when a frame rate that is ¼ the imaging frame rate is executed.Type: GrantFiled: February 11, 2014Date of Patent: June 30, 2015Assignee: SONY CORPORATIONInventors: Seiji Kobayashi, Isao Ohashi, Yoshihiko Kuroki
-
Patent number: 8933099Abstract: The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein n represents 0 to 2; A represents an arylene group or a heteroarylene group; G represents a single bond, an oxygen atom or —CH2—; E represents a nitrogen-containing non-aromatic heterocycle; R1 represents an alkoxy group or the like; R2 represents a hydrogen atom or the like; and R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom.Type: GrantFiled: February 19, 2014Date of Patent: January 13, 2015Assignee: Eisai R&D Management Co., Ltd.Inventors: Setsuo Funasaka, Toshimi Okada, Keigo Tanaka, Satoshi Nagao, Isao Ohashi, Yoshinobu Yamane, Yusuke Nakatani, Yuki Karoji
-
Publication number: 20140235614Abstract: The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein n represents 0 to 2; A represents an arylene group or a heteroarylene group; G represents a single bond, an oxygen atom or —CH2—; E represents a nitrogen-containing non-aromatic heterocycle; R1 represents an alkoxy group or the like; R2 represents a hydrogen atom or the like; and R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom.Type: ApplicationFiled: February 19, 2014Publication date: August 21, 2014Applicant: Eisai R&D Management Co., Ltd.Inventors: Setsuo Funasaka, Toshimi Okada, Keigo Tanaka, Satoshi Nagao, Isao Ohashi, Yoshinobu Yamane, Yusuke Nakatani, Yuki Karoji
-
Publication number: 20140161424Abstract: Disclosed herein are an imaging apparatus, an imaging method, a recording medium, and a program which are capable of processing imaging data in a manner similar to that of a normal frame rate. Image data captured by a solid-state imaging element capable of performing imaging at a high resolution and a high frame rate is supplied to a memory control. The memory control, at the same time as writing the imaging data input from the imaging element in a frame memory, reads preceding frames of imaging data that are recorded on the frame memory, and sequentially respectively outputs them in parallel, as video image data items, for each frame, to respective camera signal processing units. In the camera signal processing units, a video output, a viewfinder output, codec units, and recording units, processing similar to that when a frame rate that is ¼ the imaging frame rate is executed.Type: ApplicationFiled: February 11, 2014Publication date: June 12, 2014Applicant: Sony CorporationInventors: Seiji KOBAYASHI, Isao OHASHI, Yoshihiko KUROKI
-
Patent number: 8723933Abstract: A three-dimensional image correction device includes when a displacement amount which is a difference between a convergence angle on a display surface and a convergence angle on a perceived three-dimensional surface based on image information for a three-dimensional image is set as a disparity amount, a width of a depth amount represented by pop-up and pull-in of the three-dimensional image is set as a dynamic range, and display device specification information is set as display device information, a disparity amount detection unit for inputting the image information to detect the disparity amount from the image information, a correction computation unit for adjusting the detected disparity amount on the basis of the display device information to correct the dynamic range, and a disparity amount correction unit for correcting the disparity amount in the corrected dynamic range while corresponding to the display device information.Type: GrantFiled: September 5, 2012Date of Patent: May 13, 2014Assignee: Sony CorporationInventors: Shuichi Takahashi, Isao Ohashi, Takuya Ooi, Kazunari Yoshifuji
-
Publication number: 20140126807Abstract: An image processing apparatus includes: a luminance extraction means to extract luminance components of an input image; a contrast extraction means to extract contrast components of the input image based on the luminance components of the input image extracted by the luminance extraction means; a storage means to store a performance function indicating relation between the contrast components of the input image and depth amounts subjectively perceived, which is determined based at least in part on visual sense characteristics of human beings; and a contrast adjustment means to calculate present depth amounts of the input image from the contrast components of the input image extracted by the contrast extraction means based at least in part on the performance function with respect to region of the input image which are determined from depth information of the input image and adjusting contrast components of the input image.Type: ApplicationFiled: January 9, 2014Publication date: May 8, 2014Applicant: Sony CorporationInventors: Shuichi Takahashi, Takanori Ishikawa, Isao Ohashi, Satoshi Shioiri
-
Patent number: 8687079Abstract: An imaging method, a recording medium, and a program which are capable of processing imaging data of a high rate in a manner similar to that of a normal frame rate. Image data captured by a solid-state imaging element capable of performing imaging at a high resolution and a high frame rate is supplied to a memory control unit. The memory control unit, at the same time as writing the imaging data input from the imaging element in a frame memory, reads preceding frames of imaging data that are recorded on the frame memory, and sequentially respectively outputs them in parallel, as video image data items for each frame, to respective camera signal processing units. Then, in the camera signal processing units, a video output unit, a viewfinder output unit, codec units, and recording units, processing similar to that in the case of a frame rate that is ¼ the imaging frame rate is executed.Type: GrantFiled: June 30, 2008Date of Patent: April 1, 2014Assignee: Sony CorporationInventors: Seiji Kobayashi, Isao Ohashi, Yoshihiko Kuroki
-
Patent number: 8660337Abstract: An image processing apparatus includes: a depth information extraction means for extracting depth information from an input 3D image; a luminance extraction means for extracting luminance components of the 3D image; a contrast extraction means for extracting contrast components of the 3D image based on the luminance components; a storage means for storing a performance function indicating relation between the contrast components and depth amounts subjectively perceived, which is determined based on visual sense characteristics of human beings; and a contrast adjustment means for calculating present depth amounts of the inputted 3D image from the contrast components based on the performance function with respect to at least one of a near side region and a deep side region of the inputted 3D image which are determined from the depth information and adjusting contrast components of the inputted 3D image based on the calculated present depth amounts and a set depth adjustment amount.Type: GrantFiled: November 22, 2010Date of Patent: February 25, 2014Assignee: Sony CorporationInventors: Shuichi Takahashi, Takanori Ishikawa, Isao Ohashi, Satoshi Shioiri
-
Patent number: 8654182Abstract: There is provided a display device including a display unit which periodically arranges and displays a plurality of images and a parallax barrier which is disposed in front of a pixel plane of the display unit and separates light from the display unit. The display device includes a disparity extraction unit which extracts information on a distribution of disparities between the view images, a parameter calculation unit which calculates a shift amount based on the disparity distribution information, a shift processing unit which performs shift processing on at least one of the view images based on the calculated shift amount, and a mapping processing unit which rearranges the at least one shift-processed view image on the display unit.Type: GrantFiled: June 16, 2011Date of Patent: February 18, 2014Assignee: Sony CorporationInventors: Takanori Ishikawa, Kazunari Yoshifuji, Yota Komoriya, Isao Ohashi
-
Patent number: 8648876Abstract: There is provided a display including a display unit which periodically arranges and displays a plurality of view images, an acquisition unit which acquires information on a position of an observer, a calculation unit which sets a target viewing zone based on the information on the position of the observer, and a control unit which selects an arrangement of the view images that gives a viewing zone similar to the target viewing zone.Type: GrantFiled: April 1, 2011Date of Patent: February 11, 2014Assignee: Sony CorporationInventors: Kazunari Yoshifuji, Takanori Ishikawa, Yota Komoriya, Isao Ohashi
-
Publication number: 20140036045Abstract: Provided is an image processing apparatus including an arrangement determination unit configured to determine whether an arrangement of sub-pixels forming pixels of a display screen is a first arrangement in which a short dimension of the sub-pixels is arranged so as to be in a horizontal direction of the display screen, or a second arrangement in which a long dimension of the sub-pixels is arranged so as to be in the horizontal direction of the display screen, a disparity determination unit configured to determine a disparity of the determined sub-pixel arrangement, and an image generation unit configured to generate one or two or more images of other viewpoints that are different to a viewpoint of an image represented by the image signal.Type: ApplicationFiled: July 26, 2013Publication date: February 6, 2014Applicant: Sony CorporationInventors: Keita Ishikawa, Isao Ohashi