Abstract: A method of producing water-insoluble anti-cancer drug in the form of particulates, the method including preparing a water-insoluble anti-cancer drug having at least one multiple bond in the structure, and irradiating said water-insoluble anti-cancer drug with a laser beam having a wavelength of a low absorption portion in the vicinity of the foot of an absorption curve on the long wavelength side within the absorption band until said water-insoluble anti-cancer drug is formed into particulates having an average particle diameter of 50 to 200 nm.

Abstract: An objective of the present invention is to provide water-soluble prodrugs that can be administered parenterally, and which show excellent water solubility and small interspecies or individual differences and are rapidly converted to the active form by chemical conversion. This invention provides water-soluble prodrugs represented by formula (1), or pharmaceutically acceptable salts, or hydrates or solvates thereof, (wherein, R1 represents a hydrogen atom, or C1-C6 alkyl group; W represents a divalent group comprising a tertiary amino group or sulfonyl group; and Y represents a residue of a compound represented by Y—OH comprising an alcoholic hydroxyl group).

Abstract: A method of producing water-insoluble anti-cancer drug in the form of particulates, the method including preparing a water-insoluble anti-cancer drug having at least one multiple bond in the structure, and irradiating said water-insoluble anti-cancer drug with a laser beam having a wavelength of a low absorption portion in the vicinity of the foot of an absorption curve on the long wavelength side within the absorption band until said water-insoluble anti-cancer drug is formed into particulates having an average particle diameter of 50 to 200 nm.

Abstract: A guitar includes a brace bar having a longitudinal horizontal coupling portion arranged so as to be parallel along a top plate inner surface of the top plate, a pair of connecting legs bent from both ends of the horizontal coupling portion so as to be orthogonal to the longitudinal direction, and a bridge coupling leg provided along a projecting direction of the connecting leg from vicinity of the center of the horizontal coupling portion is attached to the top plate. A pair of recesses obtained by cutting the top plate into a recess form are formed on the top plate and a connecting leg of the brace bar are connected with vibrating thin plate bonded to the recesses.

Abstract: The present invention provides an industrially useful chitosan-containing composition in the form of any of a transparent aqueous solution, gel or dry powder having a neutral to weakly alkaline pH when in the form of an aqueous solution that can be applied to pharmaceutical additives, foods, beverages and cosmetics. A production process of the chitosan-containing composition of the present invention has a step for preparing an acidic chitosan aqueous solution, a step for forming a solid by removing a water-soluble salt from a salt formed by mixing an acidic polymer component into the acidic chitosan aqueous solution, and a step for dissolving the solid in a weakly basic solution.

Abstract: An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.

Abstract: It is an object to provide a stringed instrument that is configured to make it possible to improve its sound characteristic by vibrating a specific region of a table. A guitar (1) has a body (8) provided with a table (2) and the like, wherein the table (2) is equipped with laterally bridged connection portions (16) in longitudinal shapes arranged in parallel with each other along an inner surface of the table (2), a pair of cone connection legs (17a) and (17b) curved to intersect a longitudinal direction from both edges of each of the laterally bridged connection portions (16), and a breath bar (3) having a bridge connection leg (18) arranged along a projection direction of the cone connection leg (17a) and the like from a central portion of the laterally bridged connection portions (16).

Abstract: The present invention provides a PEG-modified HAP having a high degree of safety and novel functions by modifying the surface of hydroxyapatite particles with a polyethylene glycol derivative, applications thereof, and a production process of the same. The PEG-modified HAP of the present invention is a substance in which hydroxyapatite having a particle diameter of 50 ?m to 10 nm is bonded to a polyethylene glycol derivative having a carboxyl group as a terminal functional group through —O(CO) bonds, and the carbon content thereof is 10 to 0.1%. In addition, the present invention is a substance composed of this substance and a pharmaceutical active ingredient or pharmaceutical additive, in which the weight ratio of the pharmaceutical active ingredient is 1 to 30%, and the substance is obtained by treating hydroxyapatite having a particle diameter of 50 ?m to 10 nm and an active ester of polyethylene glycol derivative having a carboxyl group as a terminal functional group in an anhydrous organic solvent.

Abstract: A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.

Abstract: An apparatus for coating particles with a polymer electrolyte, which includes at least one polymer membrane shell-coating part, the particles being coated with a membrane shell in the at least one polymer membrane shell-coating part by performing a step including contacting the particles having a predetermined charge with the polymer electrolyte having a charge opposite to that of the outer surface of the particles, thereby forming a membrane shell on the surface of the outermost layer of the particles.

Abstract: Preventive or therapeutic agents for pancreatic cancer, ovarian cancer, or liver cancer of the present invention comprise a water-soluble prodrug represented by formula 1 described below, or a pharmaceutically acceptable salt, or a hydrate or solvate of the prodrug or pharmaceutically acceptable salt, (wherein, R1 represents a hydrogen atom, or a C1-C6 alkyl group; W represents a divalent group comprising a tertiary amino group or a divalent group comprising a sulfonyl group, and Y represents a residue of a compound represented by Y—OH comprising an alcoholic hydroxyl group, wherein said Y—OH is a camptothecin, a taxane, or an anticancer nucleotide).

Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.

Abstract: A method of producing a medicinal nanoparticle suspension is provided, wherein a medicinal ingredient added in a suspending solution is ground to form nanoparticles of the medicinal ingredient by irradiating the suspending solution with a laser. The process is implemented after adding a poorly water-soluble or water-insoluble medicinal ingredient of a drug in a poor solvent to form the suspending solution.

Abstract: An objective of the present invention is to provide water-soluble prodrugs that can be administered parenterally, and which show excellent water solubility and small interspecies or individual differences and are rapidly converted to the active form by chemical conversion. This invention provides water-soluble prodrugs represented by formula (1), or pharmaceutically acceptable salts, or hydrates or solvates thereof, (wherein, R1 represents a hydrogen atom, or C1-C6 alkyl group; W represents a divalent group comprising a tertiary amino group or sulfonyl group; and Y represents a residue of a compound represented by Y—OH comprising an alcoholic hydroxyl group).

Abstract: An apparatus for forming ultrafine particles, including: a light source generating a laser beam to be irradiated at an organic substance; at least one microflow channel capable of passing therethrough a suspension containing the organic substance; and a flow device for allowing the suspension containing the organic substance to continuously or intermittently pass through the microflow channel, the organic substance present in the microflow channel being irradiated with the laser beam at least once within a predetermined period, thereby forming ultrafine particles of the organic substance.

Abstract: A water-insoluble medicine in the form of particulates, having an average particle diameter of 50 to 200 nm; and a particulate complex of the water-insoluble medicine and a polymer electrolyte, having an average particle diameter of 50 to 250 nm.

Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives Which have antifungal activity and are useful for the treatment of fungal diseases.

Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.

Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.

Abstract: N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.