Patents by Inventor Ish K. Dhawan

Ish K. Dhawan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transaminase polypeptides
    Patent number: 11939602
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: March 26, 2024
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20230120624
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: November 30, 2022
    Publication date: April 20, 2023
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Transaminase polypeptides
    Patent number: 11542485
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: January 3, 2023
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20210230564
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: April 6, 2021
    Publication date: July 29, 2021
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Transaminase polypeptides
    Patent number: 10995323
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: May 4, 2021
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20200109380
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 9, 2020
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Transaminase polypeptides
    Patent number: 10550370
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 4, 2020
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20190249152
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: April 30, 2019
    Publication date: August 15, 2019
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Transaminase polypeptides
    Patent number: 10323234
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: June 18, 2019
    Assignee: Codexis, inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Transaminase polypeptides
    Patent number: 10323233
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: June 18, 2019
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20180298355
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: June 26, 2018
    Publication date: October 18, 2018
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20180201911
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: March 6, 2018
    Publication date: July 19, 2018
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Polynucleotides encoding transaminase polypeptides
    Patent number: 9944909
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: April 17, 2018
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20170073651
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: November 2, 2016
    Publication date: March 16, 2017
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • FUNGAL STRAINS
    Publication number: 20170067033
    Abstract: The present invention provides improved fungal strains. In some embodiments, the improved fungal strains find use in hydrolyzing cellulosic material to glucose.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 9, 2017
    Inventors: Dipnath Baidyaroy, Ish K. Dhawan
  • Fungal strains
    Patent number: 9528098
    Abstract: The present invention provides improved fungal strains. In some embodiments, the improved fungal strains find use in hydrolyzing cellulosic material to glucose.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: December 27, 2016
    Assignee: Codexis, Inc.
    Inventors: Dipnath Baidyaroy, Ish K. Dhawan
  • Engineered transaminase polypeptides
    Patent number: 9512410
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: December 6, 2016
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • Variant endoglucanases and related polynucleotides
    Patent number: 9464278
    Abstract: The invention provides variants of the Clostridium thermocellum endoglucanase (CelG) that have improved endoglucanase activity compared to the wild type enzyme. Also provided are related polynucleotides, compositions, vectors, host cells, and methods of use.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: October 11, 2016
    Assignee: Codexis, Inc.
    Inventors: Jie Yang, Xiyun Zhang, Ish K. Dhawan, Andrew Shaw
  • FUNGAL STRAINS
    Publication number: 20150252342
    Abstract: The present invention provides improved fungal strains. In some embodiments, the improved fungal strains find use in hydrolyzing cellulosic material to glucose.
    Type: Application
    Filed: May 20, 2015
    Publication date: September 10, 2015
    Inventors: Dipnath Baidyaroy, Ish K. Dhawan
  • Variant CBH2 cellulases and related polynucleotides
    Patent number: 9102927
    Abstract: The invention provides variants of a Streptomyces sp. CBH2 that have improved properties compared to the wild type enzyme and methods of using the variants in the hydrolysis of substrates comprising cellulose.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: August 11, 2015
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Erika Noel Segraves