Patents by Inventor Isidore Rigoutsos

Isidore Rigoutsos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11905563
    Abstract: A method of identifying a subject in need of therapeutic intervention to treat a disease or condi-tion or disease recurrence or disease progression comprising, isolating isomiRs or miRNAs from a sample obtained from the subject; and characterizing the isomiRs or miRNAs and their presence or absence in the sample to identify a signature, wherein when the signature is indicative of a di-agnosis of the disease then treatment of the subject is recommended.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: February 20, 2024
    Assignee: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Publication number: 20240018598
    Abstract: The present invention includes a method for analyzing tRNA fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of tRNA fragments. The invention further includes diagnosing, identifying or monitoring a disease or condition, a panel of engineered oligonucleotides, a kit for a high-throughput assay, and a method and system for identifying tRNA fragments.
    Type: Application
    Filed: October 6, 2022
    Publication date: January 18, 2024
    Inventor: Isidore Rigoutsos
  • Publication number: 20230282308
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Application
    Filed: December 15, 2022
    Publication date: September 7, 2023
    Applicant: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Patent number: 11715549
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: August 1, 2023
    Assignee: THOMAS JEFFERSON UNIVERSITY
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Publication number: 20230227910
    Abstract: The present invention includes a method for analyzing RNA fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of rRNA fragments. The invention also includes diagnosing, identifying or monitoring a disease or condition, and a method for identifying rRNA fragments. The invention also includes diagnosing, identifying or monitoring a glaucoma in a subject in need thereof by characterizing the identity of rRNA or tRNA fragments.
    Type: Application
    Filed: January 31, 2023
    Publication date: July 20, 2023
    Inventor: Isidore Rigoutsos
  • Patent number: 11578366
    Abstract: The present invention includes a method for analyzing RNA fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of rRNA fragments. The invention also includes diagnosing, identifying or monitoring a disease or condition, and a method for identifying rRNA fragments. The invention also includes diagnosing, identifying or monitoring a glaucoma in a subject in need thereof by characterizing the identity of rRNA or tRNA fragments.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: February 14, 2023
    Assignee: Thomas Jefferson University
    Inventor: Isidore Rigoutsos
  • Publication number: 20230041359
    Abstract: Disclosed herein are novel compositions, methods, and systems for determining whether a subject has, or is at risk of developing, or is at a given stage of a condition afflicting a tissue of interest, or determining the tissue or cell provenance of a biological sample, based on expression level of one or more of the novel miRNA and isomiR sequences disclosed herein. The compositions, methods, and systems described herein can be used to diagnose a disease or disorder, or prognose a given stage and/or progression of the disease or disorder, or determine the identity of the tissue or cell in a sample. In some embodiments, the compositions, methods, and systems described herein can be used to develop a treatment for the disease or disorder. For example, in some embodiments, the novel miRNAs can be used as therapeutics for treatment of a disease or disorder.
    Type: Application
    Filed: July 16, 2021
    Publication date: February 9, 2023
    Inventors: Isidore Rigoutsos, Phillipe Loher, Eric Londin
  • Publication number: 20220298581
    Abstract: The present invention includes a method for analyzing tRNAHisGTG fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat and/or prevent a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of tRNAHisGTG fragments. The invention further includes diagnosing, identifying or monitoring a disease or condition, a panel of engineered oligonucleotides, a kit for a high-throughput assay, and a method and system for identifying tRNAHisGTG fragments.
    Type: Application
    Filed: March 31, 2022
    Publication date: September 22, 2022
    Inventor: Isidore Rigoutsos
  • Patent number: 11293064
    Abstract: Disclosed herein are novel compositions, methods, and systems for determining whether a subject has, or is at risk of developing, or is at a given stage of a condition afflicting a tissue of interest, or determining the tissue or cell provenance of a biological sample, based on expression level of one or more of the novel miRNA and isomiR sequences disclosed herein. The compositions, methods, and systems described herein can be used to diagnose a disease or disorder, or prognose a given stage and/or progression of the disease or disorder, or determine the identity of the tissue or cell in a sample. In some embodiments, the compositions, methods, and systems described herein can be used to develop a treatment for the disease or disorder. For example, in some embodiments, the novel miRNAs can be used as therapeutics for treatment of a disease or disorder.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: April 5, 2022
    Assignee: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Phillipe Loher, Eric Londin
  • Publication number: 20210340625
    Abstract: The present invention includes a method for analyzing tRNA-derived fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat a disease or condition, disease recurrence, or disease progression comprising characterizing the identity of tRNA fragments. The invention also includes diagnosing, identifying or monitoring a disease or condition, and a method for identifying tRNA fragments. The invention also includes diagnosing, identifying or monitoring Parkinson's disease in a subject in need thereof by characterizing the identity of tRNA fragments.
    Type: Application
    Filed: October 10, 2019
    Publication date: November 4, 2021
    Inventors: Isidore Rigoutsos, Rogan MAGEE, Eric LONDIN
  • Publication number: 20210324486
    Abstract: In various aspects and embodiments the invention provides a method of detecting SARS-CoV-2 in a sample obtained from a subject, the method comprising contacting the sample with a with a composition comprising a plurality of PCR primers targeting at least one sequence selected from the group consisting of SEQ ID NOS: 1-559, thereby forming a PCR mixture; conducting PCR amplification of the PCR mixture and detection of the at least one sequence selected from the group consisting of SEQ ID NOS: 1-559; wherein an elevated level of the at least one sequence selected from the group consisting of SEQ ID NOS: 1-559 indicates the presence of SARS-CoV-2 in the sample.
    Type: Application
    Filed: April 20, 2021
    Publication date: October 21, 2021
    Inventor: Isidore Rigoutsos
  • Publication number: 20210292846
    Abstract: The present disclosure provides a method for assessing whether a uveal melanoma (UVM) patient has, or is at risk of developing a condition, the method comprising measuring the abundance of at least two isomiRs, and/or at least one tRNA derived fragment (tRF), in a biological sample obtained from the patient, and computing the difference in abundance of the at least two isomiRs and at least one tRF as an indication that the subject either has, or is at risk of developing, or is at a given stage of the condition.
    Type: Application
    Filed: March 19, 2021
    Publication date: September 23, 2021
    Inventors: Isidore Rigoutsos, Eric Londin, Rogan G. Magee
  • Publication number: 20210198745
    Abstract: The present invention includes a method for analyzing tRNAHisGTG fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat and/or prevent a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of tRNAHisGTG fragments. The invention further includes diagnosing, identifying or monitoring a disease or condition, a panel of engineered oligonucleotides, a kit for a high-throughput assay, and a method and system for identifying tRNAHisGTG fragments.
    Type: Application
    Filed: February 3, 2017
    Publication date: July 1, 2021
    Inventor: Isidore RIGOUTSOS
  • Publication number: 20200325537
    Abstract: The present invention includes a method for analyzing RNA fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of rRNA fragments. The invention also includes diagnosing, identifying or monitoring a disease or condition, and a method for identifying rRNA fragments. The invention also includes diagnosing, identifying or monitoring a glaucoma in a subject in need thereof by characterizing the identity of rRNA or tRNA fragments.
    Type: Application
    Filed: December 22, 2017
    Publication date: October 15, 2020
    Inventor: Isidore RIGOUTSOS
  • Publication number: 20200202976
    Abstract: Methods of treating a disease by leveraging positive and negative correlations between tRNA-derived fragments (tRF) and messenger RNA (mRNA) wherein said correlations can be used to establish a level of granularity that is specific to a disease of interest wherein said disease-specific positive and negative correlations can allow a level of therapeutic intervention that will be unprecedented because it will have been informed by three dimensions: at least one mRNA of interest; at least one tRF that are positively/negatively correlated with it; and, the identity of the disease in which one wishes to modulate the abundance of the at least one mRNA of interest.
    Type: Application
    Filed: May 1, 2018
    Publication date: June 25, 2020
    Applicant: Thomas Jefferson University
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Publication number: 20190249262
    Abstract: A method of identifying a subject in need of therapeutic intervention to treat a disease or condi-tion or disease recurrence or disease progression comprising, isolating isomiRs or miRNAs from a sample obtained from the subject; and characterizing the isomiRs or miRNAs and their presence or absence in the sample to identify a signature, wherein when the signature is indicative of a di-agnosis of the disease then treatment of the subject is recommended.
    Type: Application
    Filed: October 23, 2017
    Publication date: August 15, 2019
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Isidore Rigoutsos, Aristeidis G. Telonis
  • Publication number: 20170268071
    Abstract: The present invention includes a method for analyzing tRNA fragments. In one aspect, the present invention includes Sa method of identifying a subject in need of therapeutic intervention to treat a disease or disease progression comprises characterizing the identity of tRNA fragments. The invention further includes diagnosing identifying or monitoring a disease or condition, a panel of engineered oligonucleotides, a kit for a high-throughput assay, and a method and system for identifying tRNA fragments.
    Type: Application
    Filed: October 27, 2015
    Publication date: September 21, 2017
    Inventor: Isidore RIGOUTSOS
  • Publication number: 20170009295
    Abstract: Disclosed herein are novel compositions, methods, and systems for determining whether a subject has, or is at risk of developing, or is at a given stage of a condition afflicting a tissue of interest, or determining the tissue or cell provenance of a biological sample, based on expression level of one or more of the novel miRNA and isomiR sequences disclosed herein. The compositions, methods, and systems described herein can be used to diagnose a disease or disorder, or prognose a given stage and/or progression of the disease or disorder, or determine the identity of the tissue or cell in a sample. In some embodiments, the compositions, methods, and systems described herein can be used to develop a treatment for the disease or disorder. For example, in some embodiments, the novel miRNAs can be used as therapeutics for treatment of a disease or disorder.
    Type: Application
    Filed: May 2, 2014
    Publication date: January 12, 2017
    Inventors: Isidore RIGOUTSOS, Phillipe LOHER, Eric LONDIN
  • Patent number: 8912317
    Abstract: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 3,197 and one or more corresponding mature sequences having SEQ_ID NO: 3,198 through SEQ_ID NO: 6,565 is provided. Techniques are also provided for regulating gene expression.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: December 16, 2014
    Assignee: International Business Machines Corporation
    Inventors: Tien Huynh, Isidore Rigoutsos
  • Patent number: 8795987
    Abstract: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 11,928 and one or more corresponding mature sequences having SEQ_ID NO: 11,929 through SEQ_ID NO: 24,555 is provided. Techniques are also provided for regulating gene expression.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: August 5, 2014
    Assignee: International Business Machines Corporation
    Inventors: Tien Huynh, Isidore Rigoutsos