Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: A motor vehicle lighting device includes structural elements with a housing, at least one light module accommodated inside the housing, and at least one light source cooperating with an optical surface. The light module is provided with a heat sink, a generator of an air flow, and a single air duct suitable for cooperating with the generator of the air flow such as to direct the generated air flow towards the heat sink of the at least one light module. The air duct is formed by an open part added in the housing, and at least one closing structural element suitable for closing all or part of the added part.

Abstract: A motor vehicle lighting device includes structural elements with a housing, at least one light module accommodated inside the housing, and at least one light source cooperating with an optical surface. The light module is provided with a heat sink, a generator of an air flow, and a single air duct suitable for cooperating with the generator of the air flow such as to direct the generated air flow towards the heat sink of the at least one light module. The air duct is formed by an open part added in the housing, and at least one closing structural element suitable for closing all or part of the added part.

Abstract: A signaling and/or lighting device for a motor vehicle comprises a casing provided with an opening for access toward the interior of the casing and a closure cover closing off the access opening. It also comprises a support for receiving a light bulb arranged in the casing and a removable handling element by means of which it is possible to manually actuate the support to install and remove it with respect to the casing. The device comprises holding elements for the removable handling element by means of which it is possible to reversibly attach the removable handling element to the casing or to the closure cover. A method for producing such a signaling and/or lighting device for a motor vehicle is also disclosed.

Abstract: A vehicle headlight comprising at least one lighting module mounted on a support. The module comprises a base with a mounting surface inclined backward and toward the top of the headlight. The support comprises a corresponding mounting surface. Positioning means with sliders are provided on these surfaces so as to be able to extract the module and fit it by a translational movement in a direction contained within the plane of the mounting surfaces. The housing comprises a removable portion positioned in the extension of the module in the direction of translation of the positioning means with sliders. The wall of the housing comprises precuts on the circumference of the removable portion. This arrangement makes is possible to easily replace a bulky lighting module such as that of a headlight with style functions.

Abstract: A vehicle headlight comprising at least one lighting module mounted on a support. The module comprises a base with a mounting surface inclined backward and toward the top of the headlight. The support comprises a corresponding mounting surface. Positioning means with sliders are provided on these surfaces so as to be able to extract the module and fit it by a translational movement in a direction contained within the plane of the mounting surfaces. The housing comprises a removable portion positioned in the extension of the module in the direction of translation of the positioning means with sliders. The wall of the housing comprises precuts on the circumference of the removable portion. This arrangement makes is possible to easily replace a bulky lighting module such as that of a headlight with style functions.

Abstract: Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.

Abstract: Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.

Abstract: Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem cells. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.

Abstract: Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.

Abstract: Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.