Patents by Inventor Isis C. Kettelhut

Isis C. Kettelhut has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinations of tumor necrosis factors and anti-inflammatory agents and methods for treating malignant and non-malignant diseases
    Patent number: 4980160
    Abstract: This invention relates to combinations and methods for the treatment of malignant and non-malignant diseases. More particularly, this invention relates to combinations of natural or recombinant tumor necrosis factors ("TNF") and non-steroidal anti-inflammatory agents, such as indomethacin and ibuprofen, useful for the growth inhibition or killing of transformed cells. According to this invention, the non-steroidal anti-inflammatory agents are used to reduce or eliminate the toxic side effects of high doses of TNFs employed in the treatment of malignant and non-malignant neoplastic diseases. Advantageously, the combinations and methods of this invention allow the administration of higher doses of TNF than those tolerated in conventional treatment regimens based upon TNF alone.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: December 25, 1990
    Assignees: Biogen, Inc., President and Fellows of Harvard College
    Inventors: Alfred L. Goldberg, Walter C. Fiers, Isis C. Kettelhut