Abstract: A method of performing 3D vessel tree reconstruction includes providing segmented binary angiography images, applying a distance transform to the images, and generating distance transformed binary angiography images. The set of distance transformed binary angiography images are provided to a trained 3D vessel reconstruction machine learning model capable of reconstructing 3D vessels. The 3D vessel tree reconstruction machine learning model includes a multi-stage convolutional neural network comprising a multi-stage architecture with (i) a vessel centerline stage, and (ii) a radius reconstruction stage. Resultant 3D reconstructed vessel trees may be used in performing clinical assessment of coronary vessel health, and occlusion.

Abstract: A method of determining microvasculature function of a vessel inspection region, the method including: obtaining angiography images of a vessel tree in the vessel inspection region, the angiography images captured over a sampling time window during which a contrast agent has been injected into the vessel tree, and applying the angiography images to a segmentation model configured to generate segmented images of the vessel tree; providing the segmented images to a contrast intensity model and, performing, by the contrast intensity model, a contrast intensity extraction on each of the segmented images to generate a contrast intensity profile of the vessel tree over the sampling time window; providing the contrast intensity profile to a microvasculature health model configured to determine a health of the microvasculature within the vessel tree based on the contrast intensity profile; and determining, using the microvasculature health model, a microvasculature health of microvasculature of the vessel tree.

Abstract: A method of performing 3D vessel tree reconstruction includes providing segmented binary angiography images, applying a distance transform to the images, and generating distance transformed binary angiography images. The set of distance transformed binary angiography images are provided to a trained 3D vessel reconstruction machine learning model capable of reconstructing 3D vessels. The 3D vessel tree reconstruction machine learning model includes a multi-stage convolutional neural network comprising a multi-stage architecture with (i) a vessel centerline stage, and (ii) a radius reconstruction stage. Resultant 3D reconstructed vessel trees may be used in performing clinical assessment of coronary vessel health, and occlusion.

Abstract: A method of performing 3D vessel tree reconstruction includes providing segmented binary angiography images, applying a distance transform to the images, and generating distance transformed binary angiography images. The set of distance transformed binary angiography images are provided to a trained 3D vessel reconstruction machine learning model capable of reconstructing 3D vessels. The 3D vessel tree reconstruction machine learning model includes a multi-stage convolutional neural network comprising a multi-stage architecture with (i) a vessel centerline stage, and (ii) a radius reconstruction stage. Resultant 3D reconstructed vessel trees may be used in performing clinical assessment of coronary vessel health, and occlusion.

Abstract: Anatomical and functional assessment of coronary artery disease (CAD) using machine learning and computational modeling techniques deploying methodologies for non-invasive Fractional Flow Reserve (FFR) quantification based on angiographically derived anatomy and hemodynamics data, relying on machine learning algorithms for image segmentation and flow assessment, and relying on accurate physics-based computational fluid dynamics (CFD) simulation for computation of the FFR.