Abstract: The present disclosure relates to a method for treating biliary tract cancer in a subject by inhibiting tenascin W by administering to said subject a therapeutically effective amount of a modulator of said tenascin, for example a specific antibody or a siRNA. The present disclosure also encompasses methods of diagnosing cancer by measuring levels of tenascin-W, as well as method of targeted therapy using anti-tenascin-W antibodies conjugated to therapeutic agents.

Abstract: The present invention relates to a polypeptide comprising at least 13 consecutive amino acids selected from the amino acid sequence as set forth in SEQ ID NO: 1 or a variant thereof comprising at least 70% identity over said 13 consecutive amino acids, wherein said polypeptide or variant thereof interacts with Wnt3a and can be used for the treatment of diseases associated with increased beta-catenin pathway activity. The present invention also relates to a method for detecting the presence of a disease associated with fibrogenesis and to a method for assessing the severity and/or predicting the outcome of cancer.