Abstract: Disclosed are devices, systems and methods for non-invasive neuromodulation system for prompt treatment of cerebral and/or ocular strokes caused by acute dysregulated reduced cerebral blood flow (CBF) and/or ocular blood flow (OBF) by up regulation of trigemino-vascular system (TVS), and trigeminal autonomic brain reflexes (TABRs) through stimulation of ophthalmic nerve. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated centrally by intravenous administration of pharmacological dose of ascorbic acid. The site of stimulation of ophthalmic nerve includes but not limited to nasal vestibule, nasal bridge, and forehead and upper eyelid. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli.

Abstract: Disclosed are devices, systems and methods for non-invasive neuromodulation system for prompt treatment of cerebral and/or ocular strokes caused by acute dysregulated reduced cerebral blood flow (CBF) and/or ocular blood flow (OBF) by up regulation of trigemino-vascular system (TVS), and trigeminal autonomic brain reflexes (TABRs) through stimulation of ophthalmic nerve. Additionally or alternatively, the subject's sympathetic nervous system (SNS) is down regulated centrally by intravenous administration of pharmacological dose of ascorbic acid. The site of stimulation of ophthalmic nerve includes but not limited to nasal vestibule, nasal bridge, and forehead and upper eyelid. In some embodiments, the devices are handheld, portable with nose supported, having one or more intra-nasal or extra-nasal application heads. The signal can include vibration, chemical, ultrasonic, optical, electrical, hybrid electro-optical or combination of two or more of these types of stimuli.

Abstract: Disclosed are devices, systems and methods for non-invasive neuromodulation system for treating inherited or acquired retinal, choroidal and optic nerve disorders caused by acute or chronic dysregulated reduced ocular blood flow (OBF) and/or energy failure by up regulation of trigemino-vascular system (TVS), trigeminal autonomic brain reflexes (TABRs) and pancreatic trigemino-vagal reflex (TVR) through stimulation of ophthalmic nerve (V1), more specifically but not limited to SP, and CGRP containing unmyelinated C nerve fibers. The invention, in some embodiments thereof, relates to the methods for enhancing SP and CGRP expression in neurovascular tissue of the retina and choroid.

Abstract: The cytotoxic compounds are gold(III) complexes of the type [(diaminocyclohexane)AuCl2]Cl, derived from sodium tetrachloroaurate(III) dihydrate NaAuCl4.2H2O. Specifically, the cytotoxic compounds are gold complexes of isomers of 1,2-diaminocyclohexane, namely cis-(±)-1,2-(diaminocyclohexane)AuCl3, trans-(±)-1,2-(diaminocyclohexane)AuCl3 and S,S-(+)-1,2-(diaminocyclohexane)AuCl3. In order to treat cancer cells in a patient, such as human prostate cancer cells or human gastric cancer cells, an effective amount of the isomer of 1,2-(diaminocyclohexane)AuCl3 is administered to the cancer cells in the patient. The isomer of 1,2-(diaminocyclohexane)AuCl3 is preferably administered with a concentration ranging between about 10 ?M and 20 ?M.

Abstract: A cargo box for a pickup truck having a header panel with integral welding braces or struts. The cargo box has left and right sidewalls defining the left and right sides of the cargo box, respectively, a tailgate attached to the rear end of at least one of the left and right sidewalls, a cargo box floor spanning the left and right sidewalls, and a header panel having a main body spanning the front ends of the left and right sidewalls to form a front side of the cargo box. The header panel has integral left and right lateral sides extending from and integral with its main body and these are welded directly to the left and right sidewalls without any intervening brace above the level of the cargo bed floor. Left and right braces are welded to the lower end of the header panel and the left and right sidewalls at and below the cargo bed floor, so that a majority of the mass of the brace is below the lower edge of the header panel.

Abstract: A cargo box for a pickup truck having a header panel with integral welding braces or struts. The cargo box has left and right sidewalls defining the left and right sides of the cargo box, respectively, a tailgate attached to the rear end of at least one of the left and right sidewalls, a cargo box floor spanning the left and right sidewalls, and a header panel having a main body spanning the front ends of the left and right sidewalls to form a front side of the cargo box. The header panel has integral left and right lateral sides extending from and integral with its main body and these are welded directly to the left and right sidewalls without any intervening brace above the level of the cargo bed floor, Left and right braces are welded to the lower end of the header panel and the left and right sidewalls at and below the cargo bed floor, so that a majority of the mass of the brace is below the lower edge of the header panel.