Patents by Inventor Issei Nagao

Issei Nagao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of screening potential translational regulatory elements of messenger RNA
    Patent number: 6558906
    Abstract: The present invention relates to a method of screening a potential translational regulatory element of mRNA, which promotes or suppresses the translation efficiency of mRNA in a given translation system, by applying the in vitro evolution principles. Specifically, the present invention relates to a method of screening a potential translational regulatory element of mRNA, comprising the steps of synthesizing mRNAs with random oligonucleotide sequences, which are candidates of translational regulatory elements, introduced into the untranslated regions (UTRs), and selecting mRNAs with altered translation efficiency by virtue of the inserted motifs; to translational regulatory elements screened by this method; and to a method of isolating mRNA with altered translation efficiency in comparison with the native mRNA by using such a screening method.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: May 6, 2003
    Assignees: Toyota Jidosha Kabushiki Kaisha, Genesis Research Institute, Incorporated
    Inventors: Junichi Obokata, Issei Nagao
  • Methods of screening potential translational regulatory elements of messenger RNA
    Publication number: 20020086299
    Abstract: The present invention relates to a method of screening a potential translational regulatory element of mRNA, which promotes or suppresses the translation efficiency of mRNA in a given translation system, by applying the in vitro evolution principles. Specifically, the present invention relates to a method of screening a potential translational regulatory element of mRNA, comprising the steps of synthesizing mRNAs with random oligonucleotide sequences, which are candidates of translational regulatory elements, introduced into the untranslated regions (UTRs), and selecting mRNAs with altered translation efficiency by virtue of the inserted motifs; to translational regulatory elements screened by this method; and to a method of isolating mRNA with altered translation efficiency in comparison with the native mRNA by using such a screening method.
    Type: Application
    Filed: March 26, 2001
    Publication date: July 4, 2002
    Inventors: Junichi Obokata, Issei Nagao