Patents by Inventor István Hermecz

István Hermecz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4482557
    Abstract: New 3-substituted-2-oxo-tetrahydro-pyrrolo[1,2-a]pyrimidines of the formula (II) ##STR1## or a pharmaceutically acceptable acid addition or quaternary ammonium salts thereof are disclosed, whereinR is hydrogen or lower alkyl;R.sup.1 is lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl, or carbohydrazido; andR.sup.2 is hydrogen or lower alkyl. The compounds exert a positive inotropic activity on the heart and have digitalis-like activity.
    Type: Grant
    Filed: September 9, 1982
    Date of Patent: November 13, 1984
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Gyorgy Szasz, Lelle Vasvari nee Debreczy, Agnes Horvath, Tibor Breining
  • Patent number: 4472399
    Abstract: New Rutecarpine analogs are disclosed having Rutecarpine-like activity, especially diuretic activity. Also a novel process for the preparation of the Rutecarpine analogs is disclosed.
    Type: Grant
    Filed: October 2, 1981
    Date of Patent: September 18, 1984
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Sandor Virag, Lelle Vasvari, nee Debreczy, Gyorgy Szasz, Agnes Horvath, Tibor Breining, Tamas Szuts, Gyula Sebestyen
  • Patent number: 4472398
    Abstract: Antiphlogistic and anticoagulant compounds of the formula: ##STR1## wherein m is 0, 1 or 2,n is 0, 1 or 2,R is C.sub.1 to C.sub.6 alkyl,R.sub.1 is hydrogen, or C.sub.1 to C.sub.6 alkyl,R.sub.2 is hydrogen, C.sub.1 to C.sub.6 alkyl, substituted or unsubstituted amino, substituted or unsubstituted hydroxy, carboxy or a group derived from a carboxylic acid orR.sub.1 and R.sub.2 together form a --(CH.dbd.CH).sub.2 --group andR.sub.5 is 0 or imino or substituted imino.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: September 18, 1984
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Zoltan Meszaros, Jozsef Knoll, Istvan Hermecz, Agnes Horvath, Sandor Virag, Lelle Vasvari, nee Debreczy, Agoston David
  • Patent number: 4461769
    Abstract: Compounds of the formula I ##STR1## or pharmaceutically acceptable salts, hydrates, stereoisomers, optically active isomers, geometrical isomers or tautomeric forms thereof are disclosedwhereinR is hydrogen or lower alkylR.sup.1 is hydrogen, lower alkyl, styryl, or a carboxylic acid; orR and R.sup.1 together form a group of the formula --(CH.dbd.CH).sub.2 -- and in this case the broken line represents a further C--C bond, while in all other cases there is a single bond between positions 6 and 7;R.sup.2 is hydrogen, lower alkyl or hydroxy;R.sup.3 is hydrogen, lower alkyl, aryl, lower alkanoyl, carboxyl or a carboxyl acid derivative or a group of the formula --(CH.sub.2)m--COOH or a derivative thereof formed in the carboxylic group;n=1-3;R.sup.4 is hydrogen, lower alkyl which can be substituted by hydroxy or carboxy; trifluoromethyl, substituted or unsubstituted aryl, phenyl-lower alkyl or substituted or an unsubstituted heterocyclic group;R.sup.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: July 24, 1984
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Istvan Hermecz, Zoltan Meszaros, Tibor Breining, Sandor Virag, Lelle Vasvari nee Debreczy, Agnes Horvath, Gabor Nagy, Attila Mandi, Tamas Szucs, Istvan Bitter, Gyula Sebestyen
  • Patent number: 4456752
    Abstract: A process for the preparation of nitrogen bridgehead condensed pyrimidine compounds of the general formula ##STR1## [wherein R represents hydrogen or lower alkyl;R.sup.1 represents hydrogen, lower alkyl, carboxy or a derivative thereof or styryl;R.sup.2 represents hydrogen or optionally substituted lower alkyl;R.sup.3 represents hydrogen, optionally substituted lower alkyl, aryl, aralkyl, halogen, carboxy or a derivative thereof, the group --(CH.sub.2).sub.m --COOH (in which m is the integer 1, 2 or 3) or a carboxy derivative thereof, formyl, lower alkanoyl or a condensed thereof;R.sup.4 represents hydrogen, optionally substituted alkyl, aryl optionally substituted by one or more substituents, optionally substituted aralkyl, a heterocyclic group optionally substituted by one or more substituents, the group (CH.sub.2).sub.m --Het (in which m is the integer 1, 2 or 3; Het is an optionally substituted heterocyclic group);R.sup.5 represents hydrogen, C.sub.
    Type: Grant
    Filed: December 4, 1981
    Date of Patent: June 26, 1984
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Istvan Hermecz, Tibor Breining, Lelle Vasvari nee Debreczy, Agnes Horvath, Jozsef Kokosi
  • Patent number: 4452982
    Abstract: A process is disclosed for the preparation of compounds of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen or lower alkyl;R.sup.3 is carboxy, lower alkoxycarbonyl, carbamoyl, carbamoyl substituted by one or two lower alkyl groups, or cyano;R.sup.4 is hydrogen, lower alkyl, phenyl, naphthyl, phenyl or naphthyl substituted by at least one fluoro, chloro, bromo, iodo, lower alkyl, lower alkoxy, hydroxy, carboxy, or phenyl, pyridyl or tetrazolyl; andR.sup.5 is hydrogen or lower alkyl; or a pharmaceutically acceptable salt, hydrate, stereoisomer, optically active isomer, geometric isomer, or tautomer thereof, which comprises the step of aminating a racemic or optically active compound of the formula (II) ##STR2## wherein X is halogen with a compound of the formula (III) ##STR3## or a pharmaceutically acceptable acid addition salt thereof. The compound of formula (II) possess antiallergic, especially antiasthma, activity.
    Type: Grant
    Filed: May 9, 1980
    Date of Patent: June 5, 1984
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Istvan Hermecz, Tibor Breining, Lelle Vasvari nee Debreczy, Agnes Horvath, Jozsef Kokosi
  • Patent number: 4404205
    Abstract: 3 Substituted hexahydro-pyrimido[1, 2 a]azepines and quaternary derivatives, useful as antianginals are prepared. Specifically tested are 3 carboxylates and carbo hydrazides. 3 Cyano Carbamonyl and alkyl compounds are also disclosed.
    Type: Grant
    Filed: May 9, 1980
    Date of Patent: September 13, 1983
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.
    Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Gyorgy Szasz, Lelle Vasvari nee Debreczy, Agnes Horvath, Tibor Breining
  • Patent number: 4395549
    Abstract: Intermediates useful in the preparation of Rutecarpine and Rutecarpine derivatives are disclosed as well as a process for the preparation of said intermediates having the following formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are the same or different and stand for hydrogen, halogen, nitro, carboxy, nitrile, alkoxy containing 1 to 4 carbon atoms, alkoxycarbonyl containing 1 to 4 carbon atoms in the alkoxy group, alkyl containing 1 to 4 carbon atoms, amino or hydroxy or R and R.sup.1 together stand for methylenedioxy, R.sup.2 stands for hydrogen, R.sup.3 represents hydrogen or alkyl containing 1 to 4 carbon atoms, R.sup.
    Type: Grant
    Filed: October 2, 1981
    Date of Patent: July 26, 1983
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Istvan Hermecz, Jozsef Kokosi, Agnes Horvath, Zoltan Meszaros, Gyorgy Szasz, Tibor Breining, Lelle Vasvari nee Debreczy
  • Patent number: 4367229
    Abstract: Chemical compounds having an effect on the circulatory system have the formulas ##STR1## or a mixture thereof, or a pharmaceutically suitable acid-addition salt or quaternary salt thereof, whereinR is hydrogen or lower alkyl,R.sup.1 is lower alkyl, phenyl, carboxyl, lower alkoxycarbonyl, nitrile, carbamoyl or carbohydrazido,R.sup.2 is hydrogen or lower alkyl,and wherein the formula I R.sup.2 is hydrogen then R.sup.1 is other than nitrile, alkoxycarbonyl or propyl.
    Type: Grant
    Filed: May 9, 1980
    Date of Patent: January 4, 1983
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Gyorgy Szasz, Lelle Vasuarl nee Debreczy, Agnes Horvath, Tibor Breining
  • Patent number: 4321377
    Abstract: Nitrogen bridgehead compounds (pyrido-[1,2-a]-pyrimidine derivatives) which are useful intermediates in the making of known compounds of this class and which themselves possess PG-antagonist, analgesic, antiartheriosclerotic, tranquilizing and like pharmaceutical activity.
    Type: Grant
    Filed: May 2, 1979
    Date of Patent: March 23, 1982
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Istvan Hermecz, Zoltan Meszaros, Istvan Bitter, Agnes Horvath, Lelle Vasvari nee Debreczy
  • Patent number: 4291036
    Abstract: Compounds of the formula ##STR1## or pharmaceutically acceptable acid-addition or quaternart ammonium salts thereofwhereinR is hydroxy, carboxy, lower alkoxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, carbamoyl, N-loweralkyl-carbamoyl, N,N-dilower-alkyl-carbamoyl, carboazido, carbohydrazido or cyano;R.sup.2 is C.sub.1 to C.sub.6 alkyl;R.sup.3 is C.sub.1 to C.sub.6 alkyl or benzyl; andR.sup.4 is a single electron pair, hydrogen or lower alkyl; and the dotted lines represent saturated or unsaturated bonds, are disclosed with analgesic properties.
    Type: Grant
    Filed: March 14, 1980
    Date of Patent: September 22, 1981
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Jozsef Knoll, Zoltan Meszaros, Istvan Hermecz, Ferenc Fulop, Gabor Bernath, Sandor Virag, Gabor Nagy, Peter Szentmiklosi
  • Patent number: 4260612
    Abstract: Antiallergic and antiasthmatic compounds of the formula ##STR1## of which 9-phenylamino-6-methyl-4-oxo-6,7-dihydro-4H-pyrido(1,2-a)pyrimidine-3-carb oxylic acid and optically active antipodes and salts thereof are examples.
    Type: Grant
    Filed: December 11, 1978
    Date of Patent: April 7, 1981
    Assignee: Chinoin Gyogyszer es Vecyeszeti Termekek Gyara Rt.
    Inventors: Istvan Hermecz, Zoltan Meszaros, Tibor Breining, Sandor Virag, Lelle Vasvari nee Debreczi, Agnes Horvath, Gabor Nagy, Attila Mandi, Tamas Szuts, Istvan Bitteer, Gyula Sebestyen
  • Patent number: 4252807
    Abstract: An optically active or racemic fused pyrimidine derivative of the formula I ##STR1## has pharmaceutical activity in decreasing serum lipids, cholesterol deposits and, in general, against atherosclerosis.
    Type: Grant
    Filed: August 8, 1978
    Date of Patent: February 24, 1981
    Assignee: Chincin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Istvan Hermecz, Zoltan Meszaros, Sandor Virag, Lelle Vasvari, Agnes Horvath, Jozsef Knoll, Gyula Sebestyen, Agoston David
  • Patent number: 4234586
    Abstract: Antiallergic and particularly antiasthmatic compounds of the formula: ##STR1## of which 9-phenylhydrazono-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimi dine-3-carboxylic acid is an especially significant example.
    Type: Grant
    Filed: December 11, 1978
    Date of Patent: November 18, 1980
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Istvan Hermecz, Zoltan Meszaros, Tibor Breining, Sandor Virag, Lelle V. Vasvari nee Debreczy, Agnes Horvath, Gabor Nagy, Attila Mandi, Tamas Szucs, Istvan Bitter, Gyula Sebestyen
  • Patent number: 4220771
    Abstract: Pharmaceutical intermediates, morphine potentiators and other compounds have the formula ##STR1## wherein R is hydrogen, halogen, C.sub.1-4 alkyl, hydroxy, nitro, amino, carboxy or a carboxylic acid derivate radical, R.sup.1 is hydrogen or a C.sub.1-4 alkyl, R.sup.2 is hydrogen or C.sub.1-4 alkyl, R.sup.3 is hydrogen, R.sup.4 is hydrogen or C.sub.1-4 alkyl, R.sup.5 is hydrogen R.sup.6 is hydrogen or R.sup.3 and R.sup.4 and/or R.sup.5 and R.sup.6 form a chemical bond, X is oxygen or imino, m is 1, 2, 3 or 4, n is 0, 1, 2 or 3, and if n is 1, then the dotted lines can stand for bonds, with the proviso that if m=1 and n=1 and if in the 2,3-, 6,7-, 8,9- and 1,10-positions double bonds are present, and R.sup.1 and R.sup.2 are hydrogen, then R is other than 9-hydroxy or 9-methyl; if m=2 and n=1 and R.sup.2 is hydrogen, then at least one of R and R.sup.1 is other than hydrogen; and if m=2 and n=2 and R.sup.2 is hydrogen and the molecule is a 2,3,4,6,7,8,9,10-octahydro derivative, then at least one of R and R.sup.
    Type: Grant
    Filed: August 18, 1978
    Date of Patent: September 2, 1980
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt
    Inventors: Istvan Hermecz, Ferenc Fulop, Zoltan Meszaros, Gabor Bernath, Jozsef Knoll
  • Patent number: 4219649
    Abstract: Compounds of the formula: ##STR1## or pharmaceutically acceptable acid addition or quaternary ammonium salts thereofwhereinR.sup.2 is C.sub.1 to C.sub.6 alkyl:R.sup.3 is C.sub.1 to C.sub.6 alkyl;R.sup.4 is a single electron pair, hydrogen or lower alkyl; and the dotted lines indicate saturated or unsaturated bonds, are disclosed with analgesic properties.
    Type: Grant
    Filed: August 17, 1978
    Date of Patent: August 26, 1980
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT
    Inventors: Josef Knoll, Zoltan Meszaros, Istvan Hermecz, Ferenc Fulop, Gabor Bernath, Sandor Virag, Gabor Nagy, Peter Szentmiklosi
  • Patent number: 4209622
    Abstract: Pyrida-(1,2A)-pyrimidine-derivatives and a process for preparing these compounds are disclosed. These compounds possess analgesic, anti-inflammatory, and anti-pyretic properties as well as the ability to depress the central nervous system.
    Type: Grant
    Filed: March 19, 1975
    Date of Patent: June 24, 1980
    Assignee: Chinoin Gygyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Zoltan Meszaros, Jozsef Knoll, Istvan Hermecz, Lelle Vasvari, Agnes Horvath
  • Patent number: 4123533
    Abstract: Compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof are disclosed wherein R is hydrogen or C.sub.1 to C.sub.6 alkyl;R.sup.2 and R.sup.3 are each hydrogen or together form a valency bond;R.sup.6 is carboxy or C.sub.1 to C.sub.6 alkoxycarbonyl;R.sup.7 and R.sup.8 are each hydrogen or together form a valency bond;R.sup.10 is carboxy or C.sub.1 to C.sub.6 alkoxycarbonyl and the dotted line represents two hydrogen atoms or a valency bond. The compounds are useful in the treatment of atherosclerosis.
    Type: Grant
    Filed: February 4, 1977
    Date of Patent: October 31, 1978
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Istvan Hermecz, Zoltan Meszaros, Sandor Virag, Lelle Vasvari nee Debreczy, Agnes Horvath, Jozsef Knoll, Gyula Sebestyen, Agoston David
  • Patent number: 4089858
    Abstract: The present invention is concerned with the preparation of chemical intermediates, namely, beta-amino-acrylic acid ester derivatives of nitrogen heterocycles, i.e. pyridine, quinoline, quinoxaline, pyrazine, pyrimidine and the like. Said intermediates are cyclized to form pyrido-pyrimidine type final products possessing analgesic activity.
    Type: Grant
    Filed: September 17, 1975
    Date of Patent: May 16, 1978
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Zoltan Meszaros, Jozsef Knoll, Istvan Hermecz, Piroska Simon, Peter Szentmiklosy, Lelle Vasvari, Agnes Horvath, Gabor Horvath, Peter Dvortsak
  • Patent number: 4035366
    Abstract: 1-Benzal-1,2,3,4-tetrahydro-isoquinolinium-theophylline-7-acetates are used in the manufacture of geriatric compositions.
    Type: Grant
    Filed: January 22, 1974
    Date of Patent: July 12, 1977
    Assignee: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara RT
    Inventors: Peter Szentmiklosi, Zoltan Meszaros, Laszlo Tardos, Istvan Hermecz, Ilona Erdelyi, Agoston David, Lelle Vasvari nee Debreczy, Agnes Horvath