Abstract: The present disclosure provides compositions and methods for engineering ?? T cells (e.g., v?1 T cells and v?2 T cells) with an IL-15 receptor ? subunit (IL-15R?), e.g., by transduction with a viral vector, to restore IL-15 responsiveness. Further provided are populations of engineered ?? T cells and methods of using the same.

Abstract: Some aspects of the present disclosure are directed to engineered innate lymphoid cells comprising a heterologous targeting construct specific for mesothelin and uses thereof. Some aspects of the present disclosure are directed to polynucleotides encoding a chimeric antigen receptor (CAR) that specifically binds human mesothelin, host cells comprising the polynucleotide, and methods of treating a disease or condition in a subject using the same.

Abstract: Examples described herein relate to a physical layer interface device with an interface to a medium and a link controller. The link controller can attempt to form a link with another device through the interface. Based on failure to achieve link using a last successful configuration, an attempt to form a link with another device through the interface can include interleaving use of an IEEE 802.3 compatible auto-negotiation process with at least one attempt to form a link using a non-auto-negotiated mode. Based on failure to achieve link with the another device using any available link speed mode and forward error correction (FEC) scheme, an attempt is made using IEEE 802.3 compatible auto-negotiation without use of Next Pages.

Abstract: The present invention provides methods of engineering ?? T cells (e.g., v?1 T cells and v?2 T cells) by transduction with a viral vector (e.g., a viral vector with a betaretroviral pseudotype and a 5 Retroviridae family viral vector backbone). Further provided are compositions of engineered ?? T cells and methods of using the same.

Abstract: The invention relates to methods for expanding ?? T cells comprising preparing a composition enriched for ?? T cells and culturing the composition in the presence of feeder cells. Also provided is a method for engineering ?? T cells comprising preparing a composition enriched for ?? T cells, transducing the composition to express a chimeric antigen receptor (CAR) specific for a tumour associated antigen and culturing the transduced composition to expand the engineered ?? T cells. Also provided are expanded and engineered ?? T cells produced according to the described methods, which find utility in adoptive T cell therapies, chimeric receptor therapies and the like.

Abstract: The invention relates to compositions comprising NaturalKiller (NK) cells and ?? T cells, particularly for use in adoptive immunotherapy. The invention also provides method for preparing such compositions which comprises contacting a sample with an anti-TCR delta variable 1 (anti-V?1) antibody.

Abstract: According to an aspect, there is disclosed a method comprising receiving, from a producer node, producer node capabilities comprising a machine learning based assistance capability, the machine learning based assistance capability comprising machine learning based functionalities, each machine learning based functionality comprising a machine learning entity and at least one machine learning mode associated with the machine learning entity. According to another aspect, there is disclosed a method comprising identifying producer node capabilities comprising a machine learning based assistance capability, the machine learning based assistance capability comprising machine learning based functionalities, each machine learning based functionality comprising a machine learning entity and at least one machine learning mode associated with the machine learning entity; and causing transmission of the producer node capabilities to a consumer node.

Abstract: Systems, methods, apparatuses, and computer program products for improving redundant data treatment in communication systems are provided. One method may include detecting, by a network entity, that two or more flows of packets are related. The method may then include informing lower layer(s) that the packets are related along with their QoS constraints, and directing the lower layer(s) to ensure that latency, availability and/or reliability requirements of the packets are fulfilled.

Abstract: The present invention provides engineered lymphocytes (e.g., ?? T cells, NK cells, NK-like T cells, engineered innate lymphoid cells, or MAIT cells) comprising a heterologous targeting construct lacking an intracellular signaling domain capable of activating the lymphocyte on which the construct is expressed. Further provided are compositions of engineered lymphocytes (e.g., ?? T cells) and methods of using the engineered lymphocytes (e.g., ?? T cells, e.g., a part of an adoptive T cell therapy).

Abstract: Certain embodiments may relate to communication systems, and, for example, some embodiments may relate to multi-QoS level uplink grants. According to a first embodiment, a method may include transmitting, by a first network entity, one or more grants of one or more uplink resources to a second network entity. The one or more grants of one or more uplink resources includes one or more physical resource allocation parameters containing one or more logical channel groups. The method may further include receiving, by the first network entity, data from the second network entity allocated according to the one or more logical channel groups.

Abstract: Examples described herein relate to a physical layer interface device with an interface to a medium and a link controller. The link controller can attempt to form a link with another device through the interface. Based on failure to achieve link using a last successful configuration, an attempt to form a link with another device through the interface can include interleaving use of an IEEE 802.3 compatible auto-negotiation process with at least one attempt to form a link using a non-auto-negotiated mode. Based on failure to achieve link with the another device using any available link speed mode and forward error correction (FEC) scheme, an attempt is made using IEEE 802.3 compatible auto-negotiation without use of Next Pages.

Abstract: Systems, methods, apparatuses, and computer program products for deploying an unmanned vehicle base station (BS) are provided. One method may include receiving an indication from at least one device of its capability to switch to a temporary cell of an unmanned vehicle base station (BS), and determining, based on knowledge of locations on a planned path of the unmanned vehicle base station (BS), which of the at least one device is located within coverage of one of the locations on the planned path. The method may then include configuring discontinuous reception cycles or Power-Saving Mode (PSM) of the at least one device so that the at least one device is awake when the unmanned vehicle base station (BS) establishes the temporary cell.

Abstract: Systems, methods, apparatuses, and computer program products for mobility management in NR based non-terrestrial networks are provided. One method includes signaling geographical definitions of Geo-Areas (GAs) and/or an update to GA map to at least one user equipment (UE) in a network, and receiving a tracking area update (TAU) and/or radio access network (RAN)-based notification area update (RNAU) when the at least one UE detects a change in the at least one UE's GA location. The method may also include registering the change in the at least one UE's GA location, and configuring at least one of radio access network (RAN)-based notification area (RNA) or tracking area (TA) based on the registered change in the at least one UE's GA location.

Abstract: A method includes receiving, from a base station, network signaling including information about one or more of a timing advance scaling parameter, a processing-delay compensation parameter, and a timing advance extension parameters enabling threshold/condition; receiving a timing advance index from the base station; adjusting parameters for uplink transmissions using the received timing advance index for the one or more of the timing advance scaling parameter, the processing-delay compensation parameter, and the timing advance extension parameters enabling threshold/condition; and performing uplink transmissions according to the configured and adjusted parameters.