Patents by Inventor István Ling
István Ling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9926332Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.Type: GrantFiled: January 20, 2015Date of Patent: March 27, 2018Assignee: Egis Gyogyszergyar Zrt.Inventors: Agnes Kenez, Ferenc Bertha, Jozsef Barkoczy, Ferenc Antoni, Istvan Gacsalyi, Balazs Mihalik, Gabor Gigler, Krisztina Moricz, Gabor Nemeth, Agnes Angyalne Pataki, Gabor Laszlo Kapus, Adrienn Palvolgyi, Istvan Ling, Janos Petho, Gyula Simig, Balazs Volk, Lax Gyorgyi Kovanyine, Andras Dancso
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Patent number: 9822086Abstract: The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.Type: GrantFiled: January 30, 2015Date of Patent: November 21, 2017Assignee: EGIS GYOGYSZERGYAR ZRT.Inventors: Istvan Ling, Gyorgy Jeges, Gyorgyi Kovanyine Lax, Balazs Volk, Peter Gregor, Jeno Peter Seres, Andras Dancso, Zoltan Varga, Eva Szabo
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Publication number: 20170114034Abstract: The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.Type: ApplicationFiled: January 30, 2015Publication date: April 27, 2017Applicant: Egis Gyogyszergyar Zrt.Inventors: Istvan LING, Gyorgy JEGES, Gyorgyi KOVANYINE LAX, Balazs VOLK, Peter GREGOR, Jeno Peter SERES, Andras DANCSO, Zoltan VARGA, Eva SZABO
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Publication number: 20170002020Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.Type: ApplicationFiled: January 20, 2015Publication date: January 5, 2017Applicant: Egis Gyogyszergyar Zrt.Inventors: Agnes KENEZ, Ferenc BERTHA, Jozsef BARKOCZY, Ferenc ANTONI, Istvan GACSALYI, Balazs MIHALIK, Gabor GIGLER, Krisztina MORICZ, Gabor NEMETH, Agnes ANGYALNE PATAKI, Gabor Laszlo KAPUS, Adrienn PALVOLGYI, Istvan LING, Janos PETHO, Gyula SIMIG, Balazs VOLK, Lax Gyorgyi KOVANYINE, Andras DANCSO
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Patent number: 8778932Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group; R3 represents an aryl or heteroaryl group. Medicinal products containing the same which are useful in the treatment or prevention of psychiatric and neurological disorders characterized by cognitive deficits.Type: GrantFiled: March 7, 2012Date of Patent: July 15, 2014Assignees: Les Laboratoires Servier, Egis Gyogyszergyar NyrtInventors: István Ling, József Barkóczy, Ferenc Antoni, István Gascályi, György Lévay, Michael Spedding, László Hársing
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Publication number: 20120232065Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group; R3 represents an aryl or heteroaryl group. Medicinal products containing the same which are useful in the treatment or prevention of psychiatric and neurological disorders characterised by cognitive deficits.Type: ApplicationFiled: March 7, 2012Publication date: September 13, 2012Applicants: EGIS GYOGYSZERGYAR NYRT, LES LABORATOIRES SERVIERInventors: István LING, József BARKÓCZY, Ferenc ANTONI, István GACSÁLYI, György LÉVAY, Michael SPEDDING, László HÁRSING
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Patent number: 7960375Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R?, wherein R? stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.Type: GrantFiled: July 29, 2004Date of Patent: June 14, 2011Assignee: Egis Gyogyszergyar Rt.Inventors: Jozsef Barkoczy, Istvan Ling, Gyula Simig, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szücs, Geza Szabo, Miklos Vegh, Laszlo Gabor Harsing
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Publication number: 20090233913Abstract: The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties.Type: ApplicationFiled: December 29, 2006Publication date: September 17, 2009Inventors: Istvan Ling, Jozsef Barkoczy, Zoltan Greff, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szucs, Mihaly Albert, Gabor Kapus, Geza Szabo, Miklos Vegh, Marta Agoston, Gyorgy Levay, Krisztina Moricz, Laszlo Gabor Harsing
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Publication number: 20080153814Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R?, wherein R? stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.Type: ApplicationFiled: July 29, 2004Publication date: June 26, 2008Inventors: Jozsef Barkoczy, Istvan Ling, Gyula Simig, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szucs, Geza Szabo, Miklos Vegh, Laszio Gabor Harsing
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Patent number: 7189711Abstract: The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C1-4 alkyl group or a group of the formula —NR1R2, wherein R1 and R2 represent, independently, a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group or a C3-6 cycloalkyl group.Type: GrantFiled: December 19, 2001Date of Patent: March 13, 2007Assignee: Egis Gyogyszergyar RT.Inventors: István Ling, József Barkóczy, Gyula Simig, Zoltán Greff, Zoltán Rátkai, Géza Szabó, Miklós Végh, Gábor Gigler, Gábor Szénási, Bernadett Martonné Markó, György Lévay, László Gábor Hársing
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Patent number: 6600036Abstract: Compounds of formula I are described, their production and use in pharmaceutical agents.Type: GrantFiled: November 27, 2001Date of Patent: July 29, 2003Assignee: Schering AktiengesellschaftInventors: Ernese Csuzdi, Tamas Hamori, Gizella Abraham, Sandor Solyom, Istvan Tarnawa, Pal Berzsenyi, Ferenc Andrasi, Istvan Ling, Antal Simay, Melinda Gal, Katalin Horvath, Eszter Szentkuti, Marta Szollosy, Istvan Pallagi
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Patent number: 6482819Abstract: 2,3-Benzodiazepines of formula (I), their stereoisomers and acid addition salts, wherein the variables have the meaning given in the specification, and pharmaceutical compositions containing them which are suitable for treating conditions associated with muscle spasms, epilepsy as well as acute and chronic forms of neurodegenerative diseases are disclosed.Type: GrantFiled: April 10, 2000Date of Patent: November 19, 2002Assignee: Gyogyszerkutato Intezet Kft.Inventors: Gizella Ábrahám, Emese Csuzdi, Sándor Sólyom, Pál Berzsenyi, István Tarnawa, Ferenc Andrási, István Ling, Tamás Hámori, Katalin Horváth, Imre Moravcsik, István Pallagi, Antal Simay
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Patent number: 6323197Abstract: The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 mean hydrogen or different substituents; X means hydrogen or halogen; Y means C1-6 alkoxy or X and Y together mean —O—(CH2)n—O—; n means 1, 2 or 3; and A together with nitrogen forms a saturated or unsaturated five-member heterocycle which can contain between 1 and 3 nitrogen atoms and/or an oxygen atom and/or one or two carbonyl groups. Owing to their non-competitive inhibiting of the AMPA receptors, these compounds can be used as medicaments for treating diseases of the central nervous system.Type: GrantFiled: November 5, 1998Date of Patent: November 27, 2001Assignee: Schering AktiengesellschaftInventors: Ernese Csuzdi, Tamas Hámori, Gizella Ábrahám, Sändor Sólyom, István Tarnawa, Pál Berzsenyi, Ferenc Andrási, István Ling, Antal Simay, Melinda Gál, Katalin Horváth, Eszter Szentkuti, Márta Szöllosy, István Pallagi
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Patent number: 6200970Abstract: A compound of formula I in which X means hydrogen or halogen, Y means —NR3— or —N═, R1 and R2 are the same or different and mean hydrogen, C1-C6 alkyl, nitro, halogen, the group —NR8R9, —O—C1-4 alkyl, —CF3, OH or C1-6 alkanoyloxy, R3 means hydrogen, the group —CO—R10, C1-6 alkyl or C3-7 cycloalkyl, R4 means optionally substituted C1-C6 alkyl, R5 means hydrogen or R4 and R5 together mean oxygen, R6 means C1-4 alkyl, R8 and R9 are the same or different and mean hydrogen, C1-C6 alkyl or —CO—C1-6 alkyl, R10 means hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C6-10 aryl, the group —NR11R12, —O—C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or —O—C3-7 cycloalkyl, R11 and R12 are the same or different and mean hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C6-10 aryl and —C...C...Type: GrantFiled: November 5, 1998Date of Patent: March 13, 2001Assignee: Schering AktiengesellschaftInventors: István Ling, Gizella Ábrahám, Sándor Sólyom, Tamás Hámori, István Tarnawa, Pál Berzsenyi, Ferenc Andrási, Emese Csuzdi, Márta Szöllósy, Antal Simay, István Lagi, Katalin Horváth
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Patent number: 5807851Abstract: Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions.Type: GrantFiled: April 4, 1997Date of Patent: September 15, 1998Assignee: Egis Gyogyszergyar Rt.Inventors: Istvan Ling, Gizella Abraham, Pal Berzsenyi, Istvan Tarnawa, Sandor Solyom, Ferenc Andrasi, Tamas Hamori, Emese Csuzdi, Katalin Horvath, Melinda Gal, Imre Moravcsik, Marta Szollosy
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Patent number: 5756495Abstract: New 3-substituted 3H-2,3-benzodiazepine derivatives of general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and n have the meanings indicated in the description, their production as well as their use as pharmaceutical agents are described.Type: GrantFiled: January 31, 1997Date of Patent: May 26, 1998Assignee: Schering AktiengesellschaftInventors: Tamas Hamori, Istvan Tarnawa, Sandor Solyom, Pal Berzsenyi, Erzsebet Birkas, Ferenc Andrasi, Istvan Ling, Tibor Hasko, Gabor Kapus, Emese Csuzdl, Marta Szollosy, Franciska Erdo, Antal Simay, Gabor Zolyomi
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Patent number: 4785104Abstract: This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R and R.sup.1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C.sub.1-4 alkoxy group,R.sup.2 stands for a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.3 and R.sup.4 are identical or different and stand for a hydrogen atom or a C.sub.1-4 alkyl group, or R.sup.3 and R.sup.4 combined denote a methylene group,with the proviso that when R stands for 3-methoxy, R.sup.1 for 4-methoxy, R.sup.3 and R.sup.4 are identical and represent methyl or ethyl groups, R.sup.2 is other than hydrogen atom.Type: GrantFiled: May 20, 1987Date of Patent: November 15, 1988Assignee: EGIS GyogyszergyarInventors: Gyorgy Rabloczky, Jeno Korosi, Tibor Lang, Istvan Ling, Tamas Hamori, Maria Kuhar nee Kurthy, Istvan Elekes, Peter Botka, Andras Varro, Sandor Elek, Judit Sarossy nee Kincsessy, Gabor Zolyomi, Zsuzsanna Lang nee Rihmer, Imre Moravcsik