Patents by Inventor Istvan Elekes
Istvan Elekes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5047396Abstract: The present invention relates to an intravenous pharmaceutical composition comprising cyclosporin as active ingredient. The composition is composed ofa) 1 part by mass of one or more cyclosporins,b) 8 to 13 parts by mass of a monoester of a saturated hydroxylated fatty acid formed with polyethylene glycol or the mixture of said monoesters,c) 4 to 10 parts by mass of one or more intravenously administerable mono- or polivalent alcohols.The invention further relates to a process for preparing such composition.Type: GrantFiled: July 21, 1989Date of Patent: September 10, 1991Assignee: Biogal GyogyszergyarInventors: Erno Orban, Tibor Balogh, Lajos Ila, Gabor Ambrus, Antonia Jekkel, Sandor Elek, Eva Tomori, Istvan Elekes, Eva T. Sarudy, Imre Moravcsik, Lajos Siklosi
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Patent number: 4922021Abstract: The invention is directed to 1-(2,6-Dimethyl-Phenyl-amino)-2-Dimethyl-amino-Propane and the pharmaceutical composition thereof useful for the treatment of cardiac rhythm disorders.Type: GrantFiled: September 14, 1988Date of Patent: May 1, 1990Assignee: BASF AktiensellschaftInventors: Zoltan Zubovics, Lajos Toldy, Gyorgy Rabloczky, Andras Varro, Ferene Andrasi, Sandor Elek, Istvan Elekes
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Patent number: 4840948Abstract: This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R stands for a hydrogen or halogen atom, or a C.sub.1-4 alkoxy group,R.sup.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.2 and R.sup.3 are identical and denote a C.sub.1-4 alkyl group, or combined they denote a methylene group.The compounds of the general formula (I) possess valuable positive inotropic (cardiotonic) potency, are capable to increase the myocardiac contractile force (heart performance in cardiac insufficiency), thus they can be applied in the therapy of chronic heart failure and coronary ailments.Type: GrantFiled: May 20, 1987Date of Patent: June 20, 1989Assignee: EGIS GyogyszergyarInventors: Tibor Lang, Jeno Korosi, Gyorgy Rabloczky, Tamas Hamori, Maria Kuhar nee Kurthy, Istvan Polgari, Istvan Elekes, Gabor Zolyomi, Krisztina Heltai, Judit Sarossy nee Kincsesy, Zsuzsanna Lang nee Rihmer, Imre Moravcsik
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Patent number: 4835152Abstract: The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiaz epi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.Type: GrantFiled: August 20, 1987Date of Patent: May 30, 1989Assignee: Biogal GyogyszergyarInventors: Jeno Korosi, Tibor Lang, Ferenc Andrasi, Pal Berzsenyi, Peter Botka, Tamas Hamori, Katalin G. Horvath, Jozsef Borsi, Istvan Elekes, Zsuzsanna L. Rihmer
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Patent number: 4829076Abstract: The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof.The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.Type: GrantFiled: September 16, 1987Date of Patent: May 9, 1989Assignee: Alkaloida Vegyeszeti GyarInventors: Geza Szilagyi, Eva Bozo, Laszlo Czollner, Laszlo Jaszlits, Gyorgy Rabloczky, Jozsef Borsi, Istvan Elekes, Gyongyi Nagy nee Csokas, Andras Varro, ZSuzanne Lang nee Rihmer, Gyorgy Cseh, Gyula Horvath, Ilona Bodi
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Patent number: 4826845Abstract: The invention relates to novel 3(2H)-pyridazinone-derivatives of the general formula (I), pharmaceutical compositions containing them and process for their preparation. In the general formula (I) ##STR1## stands for an ethyl or propyl group substituted by a terminal halogen atom or a hydroxyl or NR.sup.1 R.sup.2 group, whereinR.sup.1 represents hydrogen atom or an unsubstituted or optionally substituted benzyl group;R.sup.2 represents hydrogen atom or an unsubstituted or optionally substituted benzo[1,4]dioxan-2-yl-methyl or -ethyl group or a (CH.sub.2).sub.n --R.sup.3 group, whereinn is 2 or 3; andR.sup.3 stands for an unsubstituted or optionally substituted phenoxy or phenylthio group; andX stands for a hydrogen or halogen atom or an unsubstituted or optionally substituted, saturated or unsaturated 5- or 6-membered heterocyclic group containing a nitrogen atom and optionally an additional heteroatom, e.g.Type: GrantFiled: October 29, 1986Date of Patent: May 2, 1989Assignee: Richter Gedeon Vegyeszeti Gyar T.R.Inventors: Endre Kasztreiner, Gyorgy Rablocsky, Nandor Makk, Laszlo Jaszlits, Peter Matyus, Gyorgy Cseh, Ildiko Pribusz nee Rapp, Klara Czako, Eszter Diesler, Istvan Elekes, Laszlo Kaufer, Maria Kuhar nee Kurthy, Judit Kincsessy, Judit Kosary, Gyongyi Nagy nee Csokas
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Patent number: 4785104Abstract: This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R and R.sup.1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C.sub.1-4 alkoxy group,R.sup.2 stands for a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.3 and R.sup.4 are identical or different and stand for a hydrogen atom or a C.sub.1-4 alkyl group, or R.sup.3 and R.sup.4 combined denote a methylene group,with the proviso that when R stands for 3-methoxy, R.sup.1 for 4-methoxy, R.sup.3 and R.sup.4 are identical and represent methyl or ethyl groups, R.sup.2 is other than hydrogen atom.Type: GrantFiled: May 20, 1987Date of Patent: November 15, 1988Assignee: EGIS GyogyszergyarInventors: Gyorgy Rabloczky, Jeno Korosi, Tibor Lang, Istvan Ling, Tamas Hamori, Maria Kuhar nee Kurthy, Istvan Elekes, Peter Botka, Andras Varro, Sandor Elek, Judit Sarossy nee Kincsessy, Gabor Zolyomi, Zsuzsanna Lang nee Rihmer, Imre Moravcsik
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Patent number: 4731383Abstract: The invention relates to new aminoguanidine derivatives of the general formula (I), ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent hydrogen or halogen atom, C.sub.1-4 alkyl, nitro, trifluoromethyl or C.sub.1-4 alkoxy group,R.sup.4 and R.sup.5 represent a C.sub.1-4 alkyl group, furthermore NR.sup.4 R.sup.5 may form a 5 to 7 membered saturated heterocyclic group containing either one or two nitrogen atoms or a nitrogen and an oxygen atom and being optionally substituted by one or two methyl, hydroxymethyl or hydroxyethyl groups,R.sup.6 and R.sup.7 each represent a hydrogen atom, normal or branched C.sub.1-4 alkyl or C.sub.2-4 alkenyl group,and to their pharmaceutically acceptable acid addition salts as well as to a process for the preparation thereof.The new compounds of the invention possess valuable antiarrhythmic activity and are devoid of the undesired circulatory side effects of the known antiarrhythmic compounds.Type: GrantFiled: October 29, 1986Date of Patent: March 15, 1988Assignee: Biogal GyogyszergyarInventors: Istvan Erczi, Jeno Marosfalvi, Gyorgy Rabloczky, Andras Varro, Maria Kuhar nee Kurthy, Istvan Elekes, Laszlo Szatmary, Laszlo Jaszlits
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Patent number: 4614740Abstract: The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same.The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable central nervous effect and in particular exert antiaggressive, anxiolytic, narcosis potentiating and soporific properties.Type: GrantFiled: July 26, 1985Date of Patent: September 30, 1986Assignee: Egis GyogyszergyarInventors: Tibor Lang, Jeno Korosi, Ferenc Andrasi, Peter Botka, Tamas Hamori, Pal Berzsenyi, Katalin Goldschmidt, Gabor Zolyomi, Istvan Elekes, Zsuzsanna Lang nee Rihmer
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Patent number: 4310549Abstract: 1-tert.-butylamino-3-(2,5-dichlorophenoxy)-2-propanol and its pharmaceutically acceptable acid addition salts possess hypotensive and bradycardizing effects. Thus they can be applied in human therapy for the treatment of hypertension and simultaneously also of tachycardia.Type: GrantFiled: September 4, 1979Date of Patent: January 12, 1982Inventors: Andor Hajos, Marton Fekete, Marianna Kurti, Tibor Lang, Lajos Toldy, Janos Borvendeg, Laszlo Nagy, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4308386Abstract: Pyridazinylhydrazones capable of lowering blood pressure have the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;R.sup.2 is chloro; andK is a group having the formula ##STR2## wherein one of R.sup.3, R.sup.4, R.sup.5 or R.sup.6 is carboxyl or alkoxycarbonyl.Type: GrantFiled: October 31, 1979Date of Patent: December 29, 1981Assignee: Richt er Gedeon Vegyeszeti Gyar Rt.Inventors: Szilagyi Geza, Endre Kasztreiner, Judit Kosary, Peter Matyus, Zsuzsa Huszti, Gyorgy Cseh, Agnes Kenessey, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4308278Abstract: 4-[(3,4-Dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives having the formula I ##STR1## wherein R.sup.1 stands for a cycloalkyl group containing from 3 to 6 carbon atoms or benzyl group;R.sup.2 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.3 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.4 stands for hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms or an alkoxycarbonyl group containing from 1 to 4 carbon atoms; andR.sup.5 stands for hydrogen atom or an alkoxycarbonyl group containing from 1 to 4 carbon atoms,are prepared by(a) reducing a hydantoin derivative having the general formula II, wherein R.sup.1 and R.sup.2 are as defined above, with lithium aluminum hydride in a neutral organic solvent, or(b) hydrogenating catalytically an 1,3-dihydro-2H-imidazol-2-one derivative having the general formula III, wherein R.sup.1 and R.sup.3 are as defined above, while the meaning of R.sup.Type: GrantFiled: November 1, 1979Date of Patent: December 29, 1981Assignee: Gyogyszerkutato IntezetInventors: Geza Schneider, Ferenc Andrasi, Pal Berzsenyi, Arpad Lazar, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4259328Abstract: Pyridazinylhydrazones capable of lowering blood pressure having the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;R.sup.2 is morpholino; andK is a group having the formula ##STR2## wherein one of R.sup.3, R.sup.4, R.sup.5 or R.sup.6 is carboxyl or alkoxycarbonyl.Type: GrantFiled: June 12, 1978Date of Patent: March 31, 1981Assignee: Richter Gedeon Vegyeszeti Gyar RtInventors: Geza Szilagyi, Endre Kasztreiner, Judit Kosary, Peter Matyus, Zsuzsa Huszti, Gyorgy Cseh, Agnes Kenessey, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4251658Abstract: 3-(1-Pyrazolyl)-pyridazine derivatives of the formula I, or pharmaceutically acceptable acid addition salts thereof, which decrease high blood pressure and inhibit catabolism or prostaglandins, ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl,R.sup.2 is hydrogen, cyano, carboxyl, carbamoyl, carbaxoyl or C.sub.1-4 alkoxycarbonyl,R.sup.3 is hydrogen or chlorine or --NR.sup.4 NHR.sup.5 or NR.sup.6 R.sup.7, wherein R.sup.4 and R.sup.5 are each hydrogen or C.sub.1-4 alkyl, wherein R.sup.6 and R.sup.7 are each hydrogen or C.sub.1-5 alkyl, C.sub.1-5 hydroxyalkyl, C.sub.3-7 cycloalkyl, phenyl or benzyl, or benzyl or phenylethyl substituted with one or two chlorine atoms or methoxy groups, or a furylmethyl, pyridylmethyl, pyrrolidine or piperazine ring, or when R.sup.7 is hydrogen, R.sup.6 is --(CH.sub.2).sub.n --NR.sup.4 R.sup.5 wherein n is an integer from 1 to 3.Type: GrantFiled: June 9, 1978Date of Patent: February 17, 1981Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Geza Szilagyi, Endre Kasztreiner, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Gyorgy Cseh, Andras Divald, Pal Tolnay, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4224325Abstract: The invention relates to compounds of general formula ##STR1## wherein R.sup.1 stands for a hydrogen atom or a C.sub.1-6 alkyl-, a C.sub.2-4 hydroxyalkyl, a C.sub.3-6 cycloalkyl or a phenyl group,R.sup.2 stands for a hydrogen, fluorine, chlorine or bromine atom or a C.sub.1-6 alkyl, a C.sub.2-4 hydroxyalkyl, a nitro or an --NR.sup.5 R.sup.6 group, wherein R.sup.5 and R.sup.6 may have the same or different meaning and stand each for a hydrogen atom or a C.sub.1-4 alkyl or a C.sub.2-4 hydroxyalkyl group,R.sup.3 stands for a hydrogen atom or a C.sub.1-6 alkyl, a C.sub.2-4 hydroxyalkyl, a C.sub.3-6 cycloalkyl or a phenyl group, a chlorine atom or a hydroxyl, amino or methoxy group,R.sup.4 stands for a carbamoyl, a cyano or an --NR.sup.7 --NHR.sup.8 group, wherein R.sup.7 and R.sup.8 may have the same or different meaning and stand each for a hydrogen atom or a C.sub.1-4 alkyl, a C.sub.2-4 hydroxyalkyl, a C.sub.1-4 alkoxycarbonyl or an --NR.sup.9 R.sup.10 group, wherein R.sup.9 and R.sup.Type: GrantFiled: July 11, 1978Date of Patent: September 23, 1980Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Geza Szilagyi, Endre Kasztreiner, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Gyorgy Cseh, Ilona Kovacs, nee Szabo, Pal Tolnay, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4119633Abstract: 2-phenoxy-, 2-phenylthio-, and 2-phenylamino-alkyl-2-oxazolines suitable for pharmaceutical use as hypolipemic and hypocholestric agents are disclosed.Type: GrantFiled: August 17, 1976Date of Patent: October 10, 1978Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Istvan Tibor Toth, Pal Bite, Gyorgy Magyar, Eszter Diszler, Jozsef Borsy, Andrea Maderspach, Istvan Polgari, Sandor Elek, Istvan Elekes
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Patent number: 4101552Abstract: 9,10-Dihydrolysergic acid-(3'-/pyrrolid-2"-on-1'-yl/-propyl)-amide, 1-methyl-9,10-dihydrolysergic acid-(thiazoline-2'-yl)-amide and lysergic acid-(3'-allyloxy-2'-oxy-propyl)-amide and their pharmaceutically acceptable acid addition salts possess antihypertensive and antiserotonin effect and exert an action on the central nervous system.Type: GrantFiled: April 23, 1976Date of Patent: July 18, 1978Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Erzsebet Mago nee Karacsony, Jozsef Borsi, Laszlo Tardos, Ildiko Kiraly, Sandor Elek, Istvan Elekes
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Patent number: 3979405Abstract: This invention relates to compounds of the formula ##SPC1##WhereinR.sup.1 is hydrogen or an alkyl group having 1-4 carbon atoms;R.sup.2 but R.sup.3 are hydrogen and if both R.sup.4 and R.sup.5 are hydrogen, R.sup.2 and R.sup.3 are alkyl groups having 1-4 carbon atoms or hydroxymethyl groups;R.sup.4 and R.sup.5 are hydrogen but where both R.sup.2 and R.sup.3 are hydrogen, R.sup.4 but R.sup.5 stand for alkyl groups having 1-4 carbon atoms, are amino groups, which may be mono or di-substituted by alkyl groups having 1-4 carbon atoms, or are allyloxymethyl groups;X is an oxygen or sulphur atom or an NH group;Y stands for a halogen atom or a halogeno-substituted phenyl group. The disclosure also concerns a process for the preparation of such compounds.Type: GrantFiled: October 16, 1973Date of Patent: September 7, 1976Assignee: Gyogyszer- es Vegyeszeti Termekek Gyara RT.Inventors: Istvan Tibor Toth, Pal Bite, Gyorgy Magyar, Eszter Diszler, Jozsef Borsy, Andrea Maderspach, Istvan Polgari, Sandor Elek, Istvan Elekes
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Patent number: 3963735Abstract: New acylated 2-aminothiazole derivatives of the general formula (I), ##SPC1##whereinR.sup.1 stands for phenyl group or a pyridyl group,R.sup.2 stands for hydrogen or lower alkyl,R.sup.3 stands for hydrogen, a lower alkyl group or benzyl group, andR.sup.4 and R.sup.5 each represent hydrogen, a C.sub.1-8 alkyl group, allyl group, a hydroxyalkyl group, a C.sub.3-6 cycloalkyl group, .beta.-dimethylaminoethyl group, .beta.-diethylaminoethyl group, benzyl group, 2-furylmethyl group, or a phenyl group having optionally a halogen, methyl, methoxy or trifluoromethyl substituent, orR.sup.4 and R.sup.5 may form, together with the adjacent nitrogen atom, a 5 to 8 membered polymethyleneimino group, morpholino group, piperazino group, N-methylpiperazino group or N-phenylpiperazino group, the compounds of formula I are anticholinergics.Type: GrantFiled: October 29, 1974Date of Patent: June 15, 1976Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Lajos Farkas, Endre Kasztreiner, Ferenc Andrasi, Jozsef Borsi, Istvan Elekes, Istvan Polgari