Abstract: The present disclosure provides compositions and methods for engineering ?? T cells (e.g., v?1 T cells and v?2 T cells) with an IL-15 receptor ? subunit (IL-15R?), e.g., by transduction with a viral vector, to restore IL-15 responsiveness. Further provided are populations of engineered ?? T cells and methods of using the same.

Abstract: Some aspects of the present disclosure are directed to engineered innate lymphoid cells comprising a heterologous targeting construct specific for mesothelin and uses thereof. Some aspects of the present disclosure are directed to polynucleotides encoding a chimeric antigen receptor (CAR) that specifically binds human mesothelin, host cells comprising the polynucleotide, and methods of treating a disease or condition in a subject using the same.

Abstract: Examples described herein relate to a physical layer interface device with an interface to a medium and a link controller. The link controller can attempt to form a link with another device through the interface. Based on failure to achieve link using a last successful configuration, an attempt to form a link with another device through the interface can include interleaving use of an IEEE 802.3 compatible auto-negotiation process with at least one attempt to form a link using a non-auto-negotiated mode. Based on failure to achieve link with the another device using any available link speed mode and forward error correction (FEC) scheme, an attempt is made using IEEE 802.3 compatible auto-negotiation without use of Next Pages.

Abstract: A current sense circuit may comprise a first circuit node and a second circuit node configured to be coupled to a first terminal and a second terminal of a current sense resistor, respectively; differential amplifier including a first input and a second input which are coupled to the first circuit node and the second circuit node via a first input resistor and a second input resistor; a voltage source, configured to set the voltage at the first input of the differential amplifier; and a controllable current mirror configured to sink or source a first current in its input branch based on one or more outputs of the differential amplifier and to generate a corresponding second current in its output branch. The input branch is coupled to the second input of the differential amplifier. A biasing circuit is coupled to the controllable current mirror.

Abstract: The present invention provides methods of engineering ?? T cells (e.g., v?1 T cells and v?2 T cells) by transduction with a viral vector (e.g., a viral vector with a betaretroviral pseudotype and a 5 Retroviridae family viral vector backbone). Further provided are compositions of engineered ?? T cells and methods of using the same.

Abstract: Examples described herein relate to a physical layer interface device with an interface to a medium and a link controller. The link controller can attempt to form a link with another device through the interface. Based on failure to achieve link using a last successful configuration, an attempt to form a link with another device through the interface can include interleaving use of an IEEE 802.3 compatible auto-negotiation process with at least one attempt to form a link using a non-auto-negotiated mode. Based on failure to achieve link with the another device using any available link speed mode and forward error correction (FEC) scheme, an attempt is made using IEEE 802.3 compatible auto-negotiation without use of Next Pages.

Abstract: Certain embodiments may relate to communication systems, and, for example, some embodiments may relate to multi-QoS level uplink grants. According to a first embodiment, a method may include transmitting, by a first network entity, one or more grants of one or more uplink resources to a second network entity. The one or more grants of one or more uplink resources includes one or more physical resource allocation parameters containing one or more logical channel groups. The method may further include receiving, by the first network entity, data from the second network entity allocated according to the one or more logical channel groups.

Abstract: The invention relates to methods for expanding ?? T cells comprising preparing a composition enriched for ?? T cells and culturing the composition in the presence of feeder cells. Also provided is a method for engineering ?? T cells comprising preparing a composition enriched for ?? T cells, transducing the composition to express a chimeric antigen receptor (CAR) specific for a tumour associated antigen and culturing the transduced composition to expand the engineered ?? T cells. Also provided are expanded and engineered ?? T cells produced according to the described methods, which find utility in adoptive T cell therapies, chimeric receptor therapies and the like.

Abstract: The invention relates to compositions comprising NaturalKiller (NK) cells and ?? T cells, particularly for use in adoptive immunotherapy. The invention also provides method for preparing such compositions which comprises contacting a sample with an anti-TCR delta variable 1 (anti-V?1) antibody.

Abstract: A current sense circuit is described herein. In accordance with one embodiment, the circuit comprises: a first circuit node and a second circuit node configured to be coupled to a first terminal and a second terminal of a current sense resistor, respectively; an differential amplifier having a first input and a second input which are coupled to the first circuit node and the second circuit node via a first input resistor and a second input resistor; a voltage source, configured to set the voltage at the first input of the differential amplifier to a predefined DC voltage; and a controllable current mirror configured to sink or source a first current in its input branch based on one or more outputs of the differential amplifier and to generate a corresponding second current in its output branch. The input branch is coupled to the second input of the differential amplifier.

Abstract: A method and corresponding system identify missing interactions in incompletely known datasets represented as complex networks. The method identifies missing connections in a complex network. The method accesses an electronic representation of the network. The network includes nodes and links, the nodes represent entities, and the links represent interactions between the entities. For each pair of nodes not directly connected by a link, the method determines a number of paths connecting the pair of nodes and calculates a prediction score for the pair of nodes based on the number of paths connecting the pair of nodes. The method ranks the pairs of nodes based on the prediction scores, resulting in an ordered list of node pairs, and selects at least a subset of the pairs of nodes based on the ordered list of node pairs. The selected pairs of nodes represent missing connections in the network.

Abstract: Systems, methods, apparatuses, and computer program products for deploying an unmanned vehicle base station (BS) are provided. One method may include receiving an indication from at least one device of its capability to switch to a temporary cell of an unmanned vehicle base station (BS), and determining, based on knowledge of locations on a planned path of the unmanned vehicle base station (BS), which of the at least one device is located within coverage of one of the locations on the planned path. The method may then include configuring discontinuous reception cycles or Power-Saving Mode (PSM) of the at least one device so that the at least one device is awake when the unmanned vehicle base station (BS) establishes the temporary cell.

Abstract: According to an aspect, there is disclosed a method comprising receiving, from a producer node, producer node capabilities comprising a machine learning based assistance capability, the machine learning based assistance capability comprising machine learning based functionalities, each machine learning based functionality comprising a machine learning entity and at least one machine learning mode associated with the machine learning entity. According to another aspect, there is disclosed a method comprising identifying producer node capabilities comprising a machine learning based assistance capability, the machine learning based assistance capability comprising machine learning based functionalities, each machine learning based functionality comprising a machine learning entity and at least one machine learning mode associated with the machine learning entity; and causing transmission of the producer node capabilities to a consumer node.

Abstract: Systems, methods, apparatuses, and computer program products for improving redundant data treatment in communication systems are provided. One method may include detecting, by a network entity, that two or more flows of packets are related. The method may then include informing lower layer(s) that the packets are related along with their QoS constraints, and directing the lower layer(s) to ensure that latency, availability and/or reliability requirements of the packets are fulfilled.

Abstract: A method includes receiving, from a base station, network signaling including information about one or more of a timing advance scaling parameter, a processing-delay compensation parameter, and a timing advance extension parameters enabling threshold/condition; receiving a timing advance index from the base station; adjusting parameters for uplink transmissions using the received timing advance index for the one or more of the timing advance scaling parameter, the processing-delay compensation parameter, and the timing advance extension parameters enabling threshold/condition; and performing uplink transmissions according to the configured and adjusted parameters.

Abstract: In accordance with example embodiments of the invention there is at least a method and apparatus to perform at least detecting, by an unmanned vehicle of a communication network, a radio connection quality degradation at the unmanned vehicle; and in response to the detecting, autonomously directing the unmanned vehicle on a rescue movement path to new geographical coordinates provided by the communication network to maintain or reestablish the radio connection. Further, to perform determining that a radio connection quality degradation is to occur or has occurred at an unmanned vehicle of a communication network; and based on the determining, providing a rescue movement path to new geographical coordinates to the unmanned vehicle for a radio connection quality degradation to maintain or reestablish the radio connection.

Abstract: The present invention provides engineered lymphocytes (e.g., ?? T cells, NK cells, NK-like T cells, engineered innate lymphoid cells, or MAIT cells) comprising a heterologous targeting construct lacking an intracellular signaling domain capable of activating the lymphocyte on which the construct is expressed. Further provided are compositions of engineered lymphocytes (e.g., ?? T cells) and methods of using the engineered lymphocytes (e.g., ?? T cells, e.g., a part of an adoptive T cell therapy).

Abstract: Certain embodiments may relate to communication systems, and, for example, some embodiments may relate to multi-QoS level uplink grants. According to a first embodiment, a method may include transmitting, by a first network entity, one or more grants of one or more uplink resources to a second network entity. The one or more grants of one or more uplink resources includes one or more physical resource allocation parameters containing one or more logical channel groups. The method may further include receiving, by the first network entity, data from the second network entity allocated according to the one or more logical channel groups.

Abstract: Examples described herein relate to a physical layer interface device with an interface to a medium and a link controller. The link controller can attempt to form a link with another device through the interface. Based on failure to achieve link using a last successful configuration, an attempt to form a link with another device through the interface can include interleaving use of an IEEE 802.3 compatible auto-negotiation process with at least one attempt to form a link using a non-auto-negotiated mode. Based on failure to achieve link with the another device using any available link speed mode and forward error correction (FEC) scheme, an attempt is made using IEEE 802.3 compatible auto-negotiation without use of Next Pages.

Abstract: Systems, methods, apparatuses, and computer program products for deploying an unmanned vehicle base station (BS) are provided. One method may include receiving an indication from at least one device of its capability to switch to a temporary cell of an unmanned vehicle base station (BS), and determining, based on knowledge of locations on a planned path of the unmanned vehicle base station (BS), which of the at least one device is located within coverage of one of the locations on the planned path. The method may then include configuring discontinuous reception cycles or Power-Saving Mode (PSM) of the at least one device so that the at least one device is awake when the unmanned vehicle base station (BS) establishes the temporary cell.