Patents by Inventor Istvan Ling

Istvan Ling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydro-oxazinobenzodiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 9926332
    Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: March 27, 2018
    Assignee: Egis Gyogyszergyar Zrt.
    Inventors: Agnes Kenez, Ferenc Bertha, Jozsef Barkoczy, Ferenc Antoni, Istvan Gacsalyi, Balazs Mihalik, Gabor Gigler, Krisztina Moricz, Gabor Nemeth, Agnes Angyalne Pataki, Gabor Laszlo Kapus, Adrienn Palvolgyi, Istvan Ling, Janos Petho, Gyula Simig, Balazs Volk, Lax Gyorgyi Kovanyine, Andras Dancso
  • Process for the preparation of vortioxetine salts
    Patent number: 9822086
    Abstract: The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: November 21, 2017
    Assignee: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Istvan Ling, Gyorgy Jeges, Gyorgyi Kovanyine Lax, Balazs Volk, Peter Gregor, Jeno Peter Seres, Andras Dancso, Zoltan Varga, Eva Szabo
  • PROCESS FOR THE PREPARATION OF VORTIOXETINE SALTS
    Publication number: 20170114034
    Abstract: The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.
    Type: Application
    Filed: January 30, 2015
    Publication date: April 27, 2017
    Applicant: Egis Gyogyszergyar Zrt.
    Inventors: Istvan LING, Gyorgy JEGES, Gyorgyi KOVANYINE LAX, Balazs VOLK, Peter GREGOR, Jeno Peter SERES, Andras DANCSO, Zoltan VARGA, Eva SZABO
  • NEW DIHYDRO-OXAZINOBENZODIAZEPINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM
    Publication number: 20170002020
    Abstract: Compounds of formula (I) having a selective dual action on the central GABAergic system, and a process for their preparation and to pharmaceutical compositions containing them.
    Type: Application
    Filed: January 20, 2015
    Publication date: January 5, 2017
    Applicant: Egis Gyogyszergyar Zrt.
    Inventors: Agnes KENEZ, Ferenc BERTHA, Jozsef BARKOCZY, Ferenc ANTONI, Istvan GACSALYI, Balazs MIHALIK, Gabor GIGLER, Krisztina MORICZ, Gabor NEMETH, Agnes ANGYALNE PATAKI, Gabor Laszlo KAPUS, Adrienn PALVOLGYI, Istvan LING, Janos PETHO, Gyula SIMIG, Balazs VOLK, Lax Gyorgyi KOVANYINE, Andras DANCSO
  • 8-chloro-2,3-benzodiazepine derivatives
    Patent number: 7960375
    Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R?, wherein R? stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: June 14, 2011
    Assignee: Egis Gyogyszergyar Rt.
    Inventors: Jozsef Barkoczy, Istvan Ling, Gyula Simig, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szücs, Geza Szabo, Miklos Vegh, Laszlo Gabor Harsing
  • OPTICAL ISOMERS OF DIHYDRO-2,3-BENZODIAZEPINES AND THEIR STEREOSELECTIVE SYNTHESIS
    Publication number: 20090233913
    Abstract: The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties.
    Type: Application
    Filed: December 29, 2006
    Publication date: September 17, 2009
    Inventors: Istvan Ling, Jozsef Barkoczy, Zoltan Greff, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szucs, Mihaly Albert, Gabor Kapus, Geza Szabo, Miklos Vegh, Marta Agoston, Gyorgy Levay, Krisztina Moricz, Laszlo Gabor Harsing
  • 8-Chloro-2,3-Benzodiazepine Derivatives
    Publication number: 20080153814
    Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R?, wherein R? stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.
    Type: Application
    Filed: July 29, 2004
    Publication date: June 26, 2008
    Inventors: Jozsef Barkoczy, Istvan Ling, Gyula Simig, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szucs, Geza Szabo, Miklos Vegh, Laszio Gabor Harsing
  • Condensed 2,3-benzodiazepine derivatives and their use as AMPA-receptor inhibitors
    Patent number: 6600036
    Abstract: Compounds of formula I are described, their production and use in pharmaceutical agents.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: July 29, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Ernese Csuzdi, Tamas Hamori, Gizella Abraham, Sandor Solyom, Istvan Tarnawa, Pal Berzsenyi, Ferenc Andrasi, Istvan Ling, Antal Simay, Melinda Gal, Katalin Horvath, Eszter Szentkuti, Marta Szollosy, Istvan Pallagi
  • 2,3-Benzodiazepine Derivatives as non-competitive AMPA
    Patent number: 5807851
    Abstract: Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: September 15, 1998
    Assignee: Egis Gyogyszergyar Rt.
    Inventors: Istvan Ling, Gizella Abraham, Pal Berzsenyi, Istvan Tarnawa, Sandor Solyom, Ferenc Andrasi, Tamas Hamori, Emese Csuzdi, Katalin Horvath, Melinda Gal, Imre Moravcsik, Marta Szollosy
  • 3-substituted 3H-2, 3-benzodiazepine derivatives, the production and use as pharmaceutical agents
    Patent number: 5756495
    Abstract: New 3-substituted 3H-2,3-benzodiazepine derivatives of general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and n have the meanings indicated in the description, their production as well as their use as pharmaceutical agents are described.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: May 26, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: Tamas Hamori, Istvan Tarnawa, Sandor Solyom, Pal Berzsenyi, Erzsebet Birkas, Ferenc Andrasi, Istvan Ling, Tibor Hasko, Gabor Kapus, Emese Csuzdl, Marta Szollosy, Franciska Erdo, Antal Simay, Gabor Zolyomi
  • 3-(hydroxymethyl)-isoquinoline derivatives
    Patent number: 4785104
    Abstract: This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R and R.sup.1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C.sub.1-4 alkoxy group,R.sup.2 stands for a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.3 and R.sup.4 are identical or different and stand for a hydrogen atom or a C.sub.1-4 alkyl group, or R.sup.3 and R.sup.4 combined denote a methylene group,with the proviso that when R stands for 3-methoxy, R.sup.1 for 4-methoxy, R.sup.3 and R.sup.4 are identical and represent methyl or ethyl groups, R.sup.2 is other than hydrogen atom.
    Type: Grant
    Filed: May 20, 1987
    Date of Patent: November 15, 1988
    Assignee: EGIS Gyogyszergyar
    Inventors: Gyorgy Rabloczky, Jeno Korosi, Tibor Lang, Istvan Ling, Tamas Hamori, Maria Kuhar nee Kurthy, Istvan Elekes, Peter Botka, Andras Varro, Sandor Elek, Judit Sarossy nee Kincsessy, Gabor Zolyomi, Zsuzsanna Lang nee Rihmer, Imre Moravcsik