Abstract: The invention provides a method of treating tumors by adminstering to a human or animal patient an effective amount of a molecule of 2 to 4 amino acids or equivalent subunits in length, which incorporates a bulky and lipophilic group comprising at least 13 non-hydrogen atoms and containing no more than 2 polar functional groups, in which the bulky and lipophilic group incorporates one or more closed rings of 5 or more non-hydrogen atoms, and in which the molecule further has at least two more cationic than anionic moieties.

Abstract: The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

Abstract: The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilizing microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

Abstract: The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

Abstract: The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilizing microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

Abstract: This invention relates to an efficient process for large scale stereoselective production of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-ones and key intermediates used for the preparation of benzofuranyl pyrroloquinolones as potent and selective PDE5 inhibitors for the treatment of erectile dysfunction, as well as pharmaceutical compositions and methods of treatment utilizing these compounds.

Abstract: The invention concerns an improved method for preparing catalysts for hydrosilylation reactions of compounds with ethylene or acetylene unsaturation (for example olefins or acetylene derivatives), in particular but not exclusively those involving polyorganosiloxanes (POS) bearing Si—H units and POS bearing Si-(ethylene or acetylene unsaturation) units. Said preparation corresponds to the following synthesis (I), wherein: A=B=carbon: T1, T2=cyclohexyl, t-butyl or methyl; T3, T4=H; DVTMS=divinyltetramethylsiloxane; t-BuOK=potassium tert-butylate; T.A=room temperature. The invention is characterised in that it consists in carrying out said synthesis in a single step by bringing together salt (III) above, Karstedt (IV) in the presence of a solvent (V) (THF) and a base (VI) (t-BuOK) at room temperature.

Abstract: The invention relates to metal complexes of formula (I) These complexes are particularly suitable for use as catalysts of hydrosilylation reactions.

Abstract: The invention concerns an improved method for preparing catalysts for hydrosilylation reactions of compounds with ethylene or acetylene unsaturation (for example olefins or acetylene derivatives), in particular but not exclusively those involving polyorganosiloxanes (POS) bearing Si—H units and POS bearing Si-(ethylene or acetylene unsaturation) units. Said preparation corresponds to the following synthesis (I), wherein: A═B=carbon: T1, T2=cyclohexyl, t-butyl or methyl; T3, T4=H; DVTMS=divinyltetramethylsiloxane; t-BuOK=potassium tert-butylate; T.A=room temperature. The invention is characterised in that it consists in carrying out said synthesis in a single step by bringing together salt (III) above, Karstedt (IV) in the presence of a solvent (V) (THF) and a base (VI) (t-BuOK) at room temperature.

Abstract: The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipoophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

Abstract: The invention relates to metal complexes of formula (I), wherein M, X, Y1, Y2, R1, R2, R5 and R6 have the meanings given in claim 1. These complexes are particularly suitable for use as catalysts of hydrosilylation reactions.