Patents by Inventor Istvan Melczer

Istvan Melczer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for producing crystalline macrolides
    Patent number: 7645876
    Abstract: The present invention provides processes for crystallization of macrolides, specifically pimecrolimus and tacrolimus.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: January 12, 2010
    Assignee: TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság
    Inventors: Vilmos Keri, Istvan Melczer, Adrienne Kovacsne-Mezei
  • METHOD OF PURIFYING PRAVASTATIN
    Publication number: 20080300305
    Abstract: The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.
    Type: Application
    Filed: August 7, 2008
    Publication date: December 4, 2008
    Inventors: Vilmos Keri, Istvan Melczer
  • Method of purifying pravastatin
    Patent number: 7425644
    Abstract: The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: September 16, 2008
    Assignee: TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság
    Inventors: Vilmos Keri, Istvan Melczer
  • Crystallization and purification of macrolides
    Publication number: 20060169199
    Abstract: The invention provides a method for crystallization and purification of tacrolimus that includes the step of providing a combination of a macrolide and a polar solvent, dopolar aprotic solvent, or hydrocarbon solvent at pH of 7 or above. The invention also provides a novel crystalline form of tacrolimus.
    Type: Application
    Filed: January 5, 2006
    Publication date: August 3, 2006
    Inventors: Vilmos Keri, Istvan Melczer, Adrienne Kovacsne-Mezei, Andrea Csorvasi
  • Method of purifying tacrolimus
    Publication number: 20060142565
    Abstract: The invention provides pure tacrolimus and a method for purifying tacrolimus in which a loading charge of tacrolimus is placed in juxtaposition with a bed of wet sorption resin, the loading charge and bed are eluted with an eluent comprising THF, acetonitrile, or a combination thereof, water, and, optionally, at least one additional organic solvent, the heart cut of the eluent is collected, and tacrolimus is collected, the tacrolimus is further crystallized and recrystallized until obtaining a reduced level of impurities.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 29, 2006
    Inventors: Vilmos Keri, Andrea Csorvasi, Istvan Melczer, Angela Simon
  • Processes for producing crystalline macrolides
    Publication number: 20060135548
    Abstract: The present invention provides processes for crystallization of macrolides, specifically pimecrolimus and tacrolimus.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 22, 2006
    Inventors: Vilmos Keri, Istvan Melczer, Adrienne Kovacsne-Mezei
  • Method of purifying pravastatin
    Publication number: 20050113446
    Abstract: The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.
    Type: Application
    Filed: November 23, 2004
    Publication date: May 26, 2005
    Inventors: Vilmos Keri, Istvan Melczer
  • Ion-exchange filtration of fermentation broth
    Publication number: 20050003499
    Abstract: The invention encompasses a process for purifying a fermentation broth by providing a fermentation broth; adjusting the pH of the fermentation broth; isolating a filtrate from the fermentation broth; and passing the filtrate through a cation-exchange resin to obtain a purified filtrate.
    Type: Application
    Filed: June 9, 2004
    Publication date: January 6, 2005
    Inventors: Vilmos Keri, Istvan Melczer, Lajos Deak, Krisztian Szeles
  • Process for the purification of cyclosporin A
    Patent number: 5382655
    Abstract: A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: January 17, 1995
    Assignee: Biogal Gyogyszerarugyar RT
    Inventors: Tibor Szanya, Laszlo Hanak, Gyongyi Strbka, Edit Nagy, Istvan Melczer, Gyorgy Deak, Berta Mako, Anita Karczub, Janos Balint, Ferenc Radnai, Erno Karacxony, Csaba Hajdufi, Vilmos Keri, Gyula Marton, Judit Dencs, Janos Kelemen