Patents by Inventor Istvan Polgari
Istvan Polgari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4840948Abstract: This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R stands for a hydrogen or halogen atom, or a C.sub.1-4 alkoxy group,R.sup.1 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sup.2 and R.sup.3 are identical and denote a C.sub.1-4 alkyl group, or combined they denote a methylene group.The compounds of the general formula (I) possess valuable positive inotropic (cardiotonic) potency, are capable to increase the myocardiac contractile force (heart performance in cardiac insufficiency), thus they can be applied in the therapy of chronic heart failure and coronary ailments.Type: GrantFiled: May 20, 1987Date of Patent: June 20, 1989Assignee: EGIS GyogyszergyarInventors: Tibor Lang, Jeno Korosi, Gyorgy Rabloczky, Tamas Hamori, Maria Kuhar nee Kurthy, Istvan Polgari, Istvan Elekes, Gabor Zolyomi, Krisztina Heltai, Judit Sarossy nee Kincsesy, Zsuzsanna Lang nee Rihmer, Imre Moravcsik
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Patent number: 4310549Abstract: 1-tert.-butylamino-3-(2,5-dichlorophenoxy)-2-propanol and its pharmaceutically acceptable acid addition salts possess hypotensive and bradycardizing effects. Thus they can be applied in human therapy for the treatment of hypertension and simultaneously also of tachycardia.Type: GrantFiled: September 4, 1979Date of Patent: January 12, 1982Inventors: Andor Hajos, Marton Fekete, Marianna Kurti, Tibor Lang, Lajos Toldy, Janos Borvendeg, Laszlo Nagy, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4308386Abstract: Pyridazinylhydrazones capable of lowering blood pressure have the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;R.sup.2 is chloro; andK is a group having the formula ##STR2## wherein one of R.sup.3, R.sup.4, R.sup.5 or R.sup.6 is carboxyl or alkoxycarbonyl.Type: GrantFiled: October 31, 1979Date of Patent: December 29, 1981Assignee: Richt er Gedeon Vegyeszeti Gyar Rt.Inventors: Szilagyi Geza, Endre Kasztreiner, Judit Kosary, Peter Matyus, Zsuzsa Huszti, Gyorgy Cseh, Agnes Kenessey, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4308278Abstract: 4-[(3,4-Dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives having the formula I ##STR1## wherein R.sup.1 stands for a cycloalkyl group containing from 3 to 6 carbon atoms or benzyl group;R.sup.2 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.3 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.4 stands for hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms or an alkoxycarbonyl group containing from 1 to 4 carbon atoms; andR.sup.5 stands for hydrogen atom or an alkoxycarbonyl group containing from 1 to 4 carbon atoms,are prepared by(a) reducing a hydantoin derivative having the general formula II, wherein R.sup.1 and R.sup.2 are as defined above, with lithium aluminum hydride in a neutral organic solvent, or(b) hydrogenating catalytically an 1,3-dihydro-2H-imidazol-2-one derivative having the general formula III, wherein R.sup.1 and R.sup.3 are as defined above, while the meaning of R.sup.Type: GrantFiled: November 1, 1979Date of Patent: December 29, 1981Assignee: Gyogyszerkutato IntezetInventors: Geza Schneider, Ferenc Andrasi, Pal Berzsenyi, Arpad Lazar, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4259328Abstract: Pyridazinylhydrazones capable of lowering blood pressure having the formula ##STR1## wherein R.sup.1 is hydrogen, chlorine, alkyl having from 1 to 4 carbon atoms, methoxy, hydroxyl, carbamoyl or cyano;R.sup.2 is morpholino; andK is a group having the formula ##STR2## wherein one of R.sup.3, R.sup.4, R.sup.5 or R.sup.6 is carboxyl or alkoxycarbonyl.Type: GrantFiled: June 12, 1978Date of Patent: March 31, 1981Assignee: Richter Gedeon Vegyeszeti Gyar RtInventors: Geza Szilagyi, Endre Kasztreiner, Judit Kosary, Peter Matyus, Zsuzsa Huszti, Gyorgy Cseh, Agnes Kenessey, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4251658Abstract: 3-(1-Pyrazolyl)-pyridazine derivatives of the formula I, or pharmaceutically acceptable acid addition salts thereof, which decrease high blood pressure and inhibit catabolism or prostaglandins, ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl,R.sup.2 is hydrogen, cyano, carboxyl, carbamoyl, carbaxoyl or C.sub.1-4 alkoxycarbonyl,R.sup.3 is hydrogen or chlorine or --NR.sup.4 NHR.sup.5 or NR.sup.6 R.sup.7, wherein R.sup.4 and R.sup.5 are each hydrogen or C.sub.1-4 alkyl, wherein R.sup.6 and R.sup.7 are each hydrogen or C.sub.1-5 alkyl, C.sub.1-5 hydroxyalkyl, C.sub.3-7 cycloalkyl, phenyl or benzyl, or benzyl or phenylethyl substituted with one or two chlorine atoms or methoxy groups, or a furylmethyl, pyridylmethyl, pyrrolidine or piperazine ring, or when R.sup.7 is hydrogen, R.sup.6 is --(CH.sub.2).sub.n --NR.sup.4 R.sup.5 wherein n is an integer from 1 to 3.Type: GrantFiled: June 9, 1978Date of Patent: February 17, 1981Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Geza Szilagyi, Endre Kasztreiner, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Gyorgy Cseh, Andras Divald, Pal Tolnay, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4224325Abstract: The invention relates to compounds of general formula ##STR1## wherein R.sup.1 stands for a hydrogen atom or a C.sub.1-6 alkyl-, a C.sub.2-4 hydroxyalkyl, a C.sub.3-6 cycloalkyl or a phenyl group,R.sup.2 stands for a hydrogen, fluorine, chlorine or bromine atom or a C.sub.1-6 alkyl, a C.sub.2-4 hydroxyalkyl, a nitro or an --NR.sup.5 R.sup.6 group, wherein R.sup.5 and R.sup.6 may have the same or different meaning and stand each for a hydrogen atom or a C.sub.1-4 alkyl or a C.sub.2-4 hydroxyalkyl group,R.sup.3 stands for a hydrogen atom or a C.sub.1-6 alkyl, a C.sub.2-4 hydroxyalkyl, a C.sub.3-6 cycloalkyl or a phenyl group, a chlorine atom or a hydroxyl, amino or methoxy group,R.sup.4 stands for a carbamoyl, a cyano or an --NR.sup.7 --NHR.sup.8 group, wherein R.sup.7 and R.sup.8 may have the same or different meaning and stand each for a hydrogen atom or a C.sub.1-4 alkyl, a C.sub.2-4 hydroxyalkyl, a C.sub.1-4 alkoxycarbonyl or an --NR.sup.9 R.sup.10 group, wherein R.sup.9 and R.sup.Type: GrantFiled: July 11, 1978Date of Patent: September 23, 1980Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Geza Szilagyi, Endre Kasztreiner, Laszlo Tardos, Edit Kosa, Laszlo Jaszlits, Gyorgy Cseh, Ilona Kovacs, nee Szabo, Pal Tolnay, Sandor Elek, Istvan Elekes, Istvan Polgari
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Patent number: 4119633Abstract: 2-phenoxy-, 2-phenylthio-, and 2-phenylamino-alkyl-2-oxazolines suitable for pharmaceutical use as hypolipemic and hypocholestric agents are disclosed.Type: GrantFiled: August 17, 1976Date of Patent: October 10, 1978Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Istvan Tibor Toth, Pal Bite, Gyorgy Magyar, Eszter Diszler, Jozsef Borsy, Andrea Maderspach, Istvan Polgari, Sandor Elek, Istvan Elekes
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Patent number: 4108855Abstract: The invention relates to a novel compound of the formula ##STR1## and the pharmaceuticlly acceptable acid addition salts thereof, wherein R stands for a hydrogen atom or methyl group, x y designates a ##STR2## Q is a hydrogen atom or a benzyloxycarbonyl- or N-tert.-butyloxycarbonyl protective group, and R.sub.1 is the side chain of a natural .alpha.-amino acid selected from the group consisting of Arg--, Tryp-13 , Phe--, Ser--, Leu--, Val--, Meth--, Tyr--, His-- or Prol---side-chain.The compounds according to the invention possess antiserotonin and hypotensive effects and act upon the central nervous system.Type: GrantFiled: March 2, 1977Date of Patent: August 22, 1978Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Erzsebet Mago nee Karacsony, Sandor Bajusz, Jozsef Borsi, Ildiko Kiraly, Endre Csanyi, Istvan Polgari
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Patent number: 3979405Abstract: This invention relates to compounds of the formula ##SPC1##WhereinR.sup.1 is hydrogen or an alkyl group having 1-4 carbon atoms;R.sup.2 but R.sup.3 are hydrogen and if both R.sup.4 and R.sup.5 are hydrogen, R.sup.2 and R.sup.3 are alkyl groups having 1-4 carbon atoms or hydroxymethyl groups;R.sup.4 and R.sup.5 are hydrogen but where both R.sup.2 and R.sup.3 are hydrogen, R.sup.4 but R.sup.5 stand for alkyl groups having 1-4 carbon atoms, are amino groups, which may be mono or di-substituted by alkyl groups having 1-4 carbon atoms, or are allyloxymethyl groups;X is an oxygen or sulphur atom or an NH group;Y stands for a halogen atom or a halogeno-substituted phenyl group. The disclosure also concerns a process for the preparation of such compounds.Type: GrantFiled: October 16, 1973Date of Patent: September 7, 1976Assignee: Gyogyszer- es Vegyeszeti Termekek Gyara RT.Inventors: Istvan Tibor Toth, Pal Bite, Gyorgy Magyar, Eszter Diszler, Jozsef Borsy, Andrea Maderspach, Istvan Polgari, Sandor Elek, Istvan Elekes
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Patent number: 3963735Abstract: New acylated 2-aminothiazole derivatives of the general formula (I), ##SPC1##whereinR.sup.1 stands for phenyl group or a pyridyl group,R.sup.2 stands for hydrogen or lower alkyl,R.sup.3 stands for hydrogen, a lower alkyl group or benzyl group, andR.sup.4 and R.sup.5 each represent hydrogen, a C.sub.1-8 alkyl group, allyl group, a hydroxyalkyl group, a C.sub.3-6 cycloalkyl group, .beta.-dimethylaminoethyl group, .beta.-diethylaminoethyl group, benzyl group, 2-furylmethyl group, or a phenyl group having optionally a halogen, methyl, methoxy or trifluoromethyl substituent, orR.sup.4 and R.sup.5 may form, together with the adjacent nitrogen atom, a 5 to 8 membered polymethyleneimino group, morpholino group, piperazino group, N-methylpiperazino group or N-phenylpiperazino group, the compounds of formula I are anticholinergics.Type: GrantFiled: October 29, 1974Date of Patent: June 15, 1976Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Lajos Farkas, Endre Kasztreiner, Ferenc Andrasi, Jozsef Borsi, Istvan Elekes, Istvan Polgari