Patents by Inventor Istvan Simonyi

Istvan Simonyi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5216157
    Abstract: The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula IIICH.sub.3 --CO--CH.sub.2 --COOCH.sub.3 (III)and optionally with an amino compound of the general Formula IV ##STR4## (wherein Z is a group of the Formula (c), ##STR5## k is 1 and both symbols p are 0; or Z stands for a C.sub.
    Type: Grant
    Filed: April 17, 1991
    Date of Patent: June 1, 1993
    Assignee: EGIS Gyogyszergyar
    Inventors: Pal Benko, Daniel Bozsing, Laszlo Levai, Gyorgyi Kovanyi nee Lax, Gyorgy Mikite, Peter Tompe, Eva Furdyga, Ilona Dinnyes nee Nagy, Eva Poczik, Gyorgyi Zalavari nee Dosa, Ivan Beck, Istvan Simonyi, Kalman Nagy, Janos Imre, Erzsebet Kiss nee Bertok, Eva J. Tajthy nee Juhasz, Attila Mandi, Frigyes Gorgenyi
  • Patent number: 5126457
    Abstract: The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.
    Type: Grant
    Filed: March 8, 1989
    Date of Patent: June 30, 1992
    Assignee: Egis Gyogyszergyar
    Inventors: Pal Benko, Daniel Bozsing, Laszlo Levai, Gyorgyi Kovanyi nee Lax, Gyorgy Mikite, Peter Tompe, Eva Furdyga, Ilona Dinnyes nee Nagy, Eva Poczik, Gyorgyi Zalavari nee Dosa, Ivan Beck, Istvan Simonyi, Kalman Nagy, Janos Imre, Erzsebet Kiss nee Bertok, Eva J. Tajthy nee Juhasz, Attila Mandi, Frigyes Gorgenyi
  • Patent number: 5047434
    Abstract: The invention relates to weight gain-increasing compositions, particularly fodder supplement, premix, drinking water supplement, bolus and/or microcapsule containing 0.001 to 90% by weight of 1-(3,5-dihydroxyphenyl)-2-(tertiary butylamino)-ethanol or a physiologically acceptable acid addition salt thereof as active ingredient in admixture with inert solid and/or liquid carrier(s).
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: September 10, 1991
    Assignee: Egis Gyogyszergyar
    Inventors: Ferenc Simon, Karoly Magyar, Attila Nagy, Lajos Fekete, Laszlo Puskas, Pal Fekete, Istvan Simonyi, Janos Egri, Katalin Zukovics nee Sumeg
  • Patent number: 4883798
    Abstract: The compounds of the general Formula I ##STR1## (wherein R.sup.1 and R.sup.2 may be the same or different and each stands for hydrogen, hydroxy, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy-C.sub.1-6 alkoxy, C.sub.2-6 alkenyloxy or phenyl-(C.sub.1-3 alkoxy), or R.sup.1 and R.sup.2 together form C.sub.1-2 alkylenedioxy; with the proviso that at least one of symbols R.sup.1 and R.sup.2 is other than hydrogen and with the further proviso that R.sup.1 and R.sup.2 can not represent 3,4-dimethoxy substitution) andtheir pharmaceutically acceptable acid addition salts exhibit useful analgesic, antipyretic, anti-inflammatory, anti-anginal and antioxidant effect.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: November 28, 1989
    Assignee: EGIS Gyogyszergyar
    Inventors: Lujza Petocz, Istvan Simonyi, Ivan Beck, Gabor Gigler, Marton Fekete, Eniko Szirt nee Kiszelly, Attila Mandi, Frigyes Gorgenyi, Andras Dietz, Elemer Jakfalvi, Katalin Zukovics nee Sumeg, Klara Gado, Maria Hegedus
  • Patent number: 4873249
    Abstract: The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.The pharmaceutical compositions of the present invention exhibit the desired analgesic and anti-inflammatory effect without causing undesired ulcerogenic side-effects.
    Type: Grant
    Filed: February 20, 1987
    Date of Patent: October 10, 1989
    Assignee: EGIS Gyogyszergyar
    Inventors: Lujza Petocz, Istvan Simonyi, Ivan Beck, Gabor Gigler, Marton Fekete, Eniko Kiszelly, Attila Mandi, Frigyes Gorgenyi, Andras Dietz, Katalin Sumeg nee Zukovics, Elemer Jakfalvi
  • Patent number: 4871728
    Abstract: The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) ##STR1## and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails.The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.
    Type: Grant
    Filed: August 12, 1988
    Date of Patent: October 3, 1989
    Assignee: EGIS Cyogyszergvar
    Inventors: Gyula Sebestyen, Istvan Simonyi, Gizelle Miholics, Marta Kovacs, Frigyes Gorgenyi, Marton Fekete, Pal Vago, Istvan Seres, Janos Egri, Maria Szeli
  • Patent number: 4868172
    Abstract: The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) ##STR1## and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails.The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: September 19, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Gyula Sebestyen, Istvan Simonyi, Gizella Miholics, Marta Kovacs, Frigyes Gorgenyi, Marton Fekete, Pal Vago, Istvan Seres, Egri Janos, Maria Szeli