Patents by Inventor Istvan Teplan
Istvan Teplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060189539Abstract: The present invention provides peptides and pharmacologically active compounds including gonadotropin-releasing hormone (GnRH) analogues according to formulas of the invention, wherein the compounds show an antitumour effect. The invention additionally provides compositions including these peptides and compounds.Type: ApplicationFiled: October 28, 2003Publication date: August 24, 2006Inventors: Sandor Lovas, Richard Murphy, Geza Toth, Adrienn Kalnay, Dezso Gaal, Istvan Palyi, Gizella Turi, Borbala Vincze, Imre Mezom, Henrietta Tanai, Zsolt Vadasz, Istvan Teplan, Janos Seprodi, Edit Szabo, Janos Pato, Melinda Mora
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Patent number: 6689813Abstract: The invention relates to the use of peptide amides of formula (I) and phenylamino-oxoacetic acid derivatives of formula (II) as well as the salts of the above compounds as active substances for the preparation of pharmaceutical compositions possessing neurogenic and non-neurogenic antiinflammatory as well as analgetic effects.Type: GrantFiled: January 5, 2001Date of Patent: February 10, 2004Assignee: Biostatin Gyogyszerkutato-Fejleszto kft.Inventors: György Kéri, János Szolcsányi, Erika Pintér, Zsuzsanna Helyes, Judit Érchegyi, Anikó Horváth, Judith Horváth, István Teplán, László Õrfi
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Patent number: 6664369Abstract: The present invention provides peptides and pharmacologically active compounds including gonadotropin-releasing hormone (GnRH) analogues according to formulas of the invention, wherein the compounds show an antitumor effect. The invention additionally provides compositions including these peptides and compounds.Type: GrantFiled: July 27, 2000Date of Patent: December 16, 2003Assignee: Creighton UniversityInventors: Sandor Lovas, Richard F. Murphy, Geza Toth, Adrienn Kalnay, Istvan Palyi, Gizella Turi, Borbala Vincze, Imre Mezom, Zsolt Vadasz, Istvan Teplan, Janos Seprodi, Melinda Mora
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Patent number: 6297216Abstract: The invention features novel peptide derivatives called Reversins, and provides for their use in a method of reducing the activity of the multi-drug transporter protein MDR1 in order to overcome multidrug resistance in a mammal. The peptide derivatives are of the formula (I) X1n-X2-X3(X4)n-X5, wherein n is 0 or 1, and each n is the same or different; X1 is BOC, BOC-Asu, Z-Asu, benzyloxycarbonyl, Glu(OBzl)-OBzl, Trp-OMe, Trp-Phe-OMe, Phe-Trp-OMe, Phe-Phe-OtBu, Trp-Trp-OtBu, indoloacetyl, benzoyl, an alkylanine of 1-4 carbons, dibenzylamide, tryptamide, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylamide or dicyclohexylamide; X2 is Glu(OBzl), Asp(OBzl), succinyl, O,O-dibenzoyltartaroyl, diphenoyl, muconyl, Thx, Cpa, Asu, Nal, Pen, Phg, Dbt, Lys(BOC), Lys(Z), Cys(Bzl), Thr(Bzl), Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Phe, Tyr(Bzl), or Ser(Bal); X3 is Asp, Asu, Lys, Glu, Trp, Thx, Cpa, Nal, Pen, Phg, Dbt, Glu(OtBu), tert.Type: GrantFiled: February 19, 1997Date of Patent: October 2, 2001Assignee: Solvo BiotechnologyInventors: Balazs Sarkadi, Janos Seprodi, Orsolya Csuka, Maria Magocsi, Imre Mezo, Istvan Palyi, Istvan Teplan, Zsolt Vadasz, Borbala Vincze
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Publication number: 20010009899Abstract: The invention relates to the use of peptide amides of formula (I) 1Type: ApplicationFiled: January 5, 2001Publication date: July 26, 2001Inventors: Gyorgy Keri, Janos Szolcsanyi, Erika Pinter, Zsuzsanna Helyes, Judit Erchegyi, Aniko Horvath, Judit Horvath, Istvan Teplan, Laszlo Orfi
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Patent number: 5593965Abstract: The present invention provides a novel pharmaceutical composition for the treatment of breast cancer. Also provided are various methods of treating breast cancer.Type: GrantFiled: October 20, 1994Date of Patent: January 14, 1997Assignee: Creighton UniversityInventors: Sandor Lovas, J. Michael Conlon, Borbala Vincze, Istvan Palyi, Dezso Gaal, Adrienn Kalnay, Imre Mezo, Istvan Teplan, Geza Toth, Magdolna Kovacs
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Patent number: 5480870Abstract: The invention relates to tumor-inhibiting heptapeptide and octapeptide amide derivatives and to a method of treating mammals, including men, suffering from tumors or from the excessive secretion of insulin, glucagon or growth hormone using these compounds.Type: GrantFiled: April 26, 1994Date of Patent: January 2, 1996Assignee: Biosignal Kutato-FejlesztokftInventors: Gyorgy Keri, Imre Mezo, Aniko Horvath, Zsolt Vadasz, Istvan Teplan, Agnes Balogh, Orsolya Csuka, Gyongyi Bokonyi, Balas Szoke, Judit Horvath, Miklos Idei, Janos Seprodi
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Patent number: 5023322Abstract: The invention relates to new peptides of the formula ##STR1## wherein R.sup.2 represents Ala or D-Ala,R.sup.11 represents Arg or D-Arg,R.sup.13 represents Val or Ile,R.sup.15 represents Gly, Leu, Phe or a valence bond,R.sup.27 represents Met or Nle,R.sup.28 represents Ser, D-Ser or Asn, andY represents OH or NH.sub.2,and to salts thereof. These compounds stimulate the release of growth hormone and can be used in the therapy as well as for veterinary or animal husbandry purposes.Type: GrantFiled: August 30, 1989Date of Patent: June 11, 1991Assignee: MTA Kutatas-es Szervezetelemzo IntezeteInventors: Magdolna Kovacs, Judit Horvath, Sandor Vigh, Imre Mezo, Istvan Teplan, Balazs Szoke, Janos Seprodi, Zsolt Vadasz, Edit Hegedus, Gabor Makara, Gyorgy Rappay
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Patent number: 4948873Abstract: The present invention relates to novel gonadoliberine analogues of formula IGlp-His-Trp-Ser-X-W-Leu-Arg-Pro-Y (I)whereinX is Phe-, Tyr (3,5-.sup.3 H) or 3,5-dibromo-tyrosyl,W is Asu or Asp OR, wherein R is alkyl having 1 to 6 carbon atoms or phenyl or phenyl (alkyl having 1 to 4 carbon atoms), which latter two groups may optionally be substituted by nitro or one or more halogen atoms, andY is glycinamide, aza-glycinamide or alkylamino having 1 to 4 carbon atoms,and acid-addition salts thereof, processes for preparing the same and pharmaceutical compositions comprising the same.The novel compounds have an influence on the sexual processes.Type: GrantFiled: October 21, 1986Date of Patent: August 14, 1990Assignee: Richter Gedeon Vegyeszeti GyarInventors: Janos Seprodi, Istvan Teplan, Istvan Schon, Judit Erchegyi, Zsolt Vadasz, Olga N. nee Kuprina, Tamas Szirtes, Andras Selmezci, Bela Kanyicska
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Patent number: 4758552Abstract: The invention relates to novel gonadoliberin nonapeptide ethylamide or decapeptide amide derivatives of the general formula (I),Glp-His-Trp-Ser-Tyr-X.sub.1 -X.sub.2 -X.sub.3 -Pro-X.sub.4 (I)whereinX.sub.1 stands for a 2-aminobenzoic or 3-aminobenzoic acid group;X.sub.2 stands for a leucyl, tryptophyl or phenylalanyl group;X.sub.3 means an arginyl, leucyl or glutaminyl group; andX.sub.4 represents a glycylamide or ethylamide group, as well as their acid addition salts and pharmaceutical presparations containing these compounds. Further on, the invention relates to a process for preparing these compounds and preparations.The gonadoliberin derivatives of the invention can more effectively be used for reproduction biological purposes as compared to the derivatives known so far.Type: GrantFiled: January 2, 1987Date of Patent: July 19, 1988Assignee: Innofinance Altalanos Innovacios PenzintezetInventors: Tamas Gulyas, Istvan Teplan, Aniko Horvath, Gyorgy Keri, Bokonyi Istvane, Sandor Vigh
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Patent number: 4753928Abstract: The invention relates to a process for producing sexual products suitable for natural or artificial fertilization from mammalia through controlling the activity of their sexual organs in their pre- and post-natal lives, during their infancy, puberty and mature state and, in a given case, to produce offsprings from them as well as to increase several times the production of sexual products to a level far above that typical of the life's performance of the species. According to the invention the mammalia are treated at least once and at most 60 times with a compound of general formula (I),Glp-His-Trp-Ser-Tyr-X.sub.1 -X.sub.2 -X.sub.3 -Pro-X.sub.4, (I)whereinX.sub.1 means a glycil-group or any other natural or synthetic D-aminoacid group,X.sub.2 means an L-aminoacid-group with a side chain of an alkyl-, phenyl, or triptophyl group containing 1-4 carbon atoms,X.sub.3 means an L-aminoacid group having a side chain of an alkyl group with 1-4 carbon atoms or an alkanoyl-amide group of 2-4 carbon atoms andX.sub.Type: GrantFiled: July 18, 1986Date of Patent: June 28, 1988Assignee: INNOFINANCE Altalanos Innovacios PengintezetInventors: Tamas Gulyas, Csaba Banhazi, Zoltan Graf, Aniko Horvath, Gyorgy Keri, Eszter Kovats, Istvan Teplan
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Patent number: 4751215Abstract: The invention relates to a process for increasing the sexual activity of birds and useful domestic mammals and for preparing spermatozoa suitable to their propagation. The process of the invention comprises treating sexually mature male birds or useful domestic mammals at least twice and at most four times with 0.1 to 5 .mu.g/kg of body weight of a compound of the general formula (I),Glp-His-Trp-Ser-Tyr-X.sub.1 -Leu-Arg-Pro-X.sub.4 (I)whereinX.sub.1 stands for a glycyl group, a natural or synthetic aminoacid or aminoacid derivative of D configuration, an -Asp-Q group of L configuration, wherein Q is attached to the .alpha.-carbonyl moiety of the aspartyl group and represents a C.sub.1-5 alkylamide, an arylamide, a C.sub.1-4 alkoxy or a benzyloxy group; andX.sub.4 stands for a glycylamide or a C.sub.1-4 alkylamide group,while keeping a pause of at least 30 hours and at most 72 hours between the consecutive treatments.Type: GrantFiled: April 15, 1986Date of Patent: June 14, 1988Assignee: INNOFINANCE Altalanos Innovacios PenzintezetInventors: Janos Seprodi, Zsolt Vadasz, Peter Peczely, Istvan Teplan, Judit Erchegyi, Tibor Muray, Istvan Gyorvari
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Patent number: 4647552Abstract: The invention relates to a process for obtaining ready-for-fertilization sexual products from sexually mature fish in a period independent of their natural spawning season, in which actual stage of ripening is determined by probing of sexual products [sperm or eggs], fish not yet ripe for ovulation are separated from ripe fish, compounds of hormonal effect are administered to fish, and after the ovulation sexual products are obtained from the fish or from their environment.In the process according to the invention a nonapeptide-C.sub.1-4 -alkyl-amide or a decapeptide amide of the general formula (I),Glp-His-Trp-Ser-Tyr-X.sub.1 -X.sub.2 -X.sub.3 -Pro-X.sub.4 (I)whereinX.sub.1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group,X.sub.2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl or L-tryptophyl group,X.sub.3 represents an L-amino acid group having a C.sub.1-4 alkyl or C.sub.2-4 alkyl-amide side chain,X.sub.4 is a glycine-amide or a C.Type: GrantFiled: December 20, 1984Date of Patent: March 3, 1987Assignee: Kozponti Valto-es Hitelbank Rt. Innovacios AlapInventors: Tamas Gulyas, Aniko Horvath, Gyorgy Keri, Karoly Nikolics, Balazs Szoke, Istvan Teplan
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Patent number: 4647553Abstract: The invention relates to gonadoliberin derivatives of the general formula (I)Glp--His--Trp--Ser--Tyr--X.sub.1 --X.sub.2 --X.sub.3 --Pro--X.sub.4whereinX.sub.1 is a glycyl group or a D-isomer of any natural or synthetic amino acid group,X.sub.2 represents an L-amino acid group having 1 to 4 carbon atoms in the side chain, L-phenyl-alanyl or L-tryptophyl group,X.sub.3 represents an L-amino acid group having a C.sub.1-4 alkyl or C.sub.2-4 alkanoyl-amide side chain, andX.sub.4 is a glycine amide or a C.sub.1-4 alkyl amide group,with the proviso that if X.sub.1 stands for a group other than glycyl and X.sub.2 is a tryptophyl group then X.sub.3 may not be leucyl, and the addition salts formed with therapeutically useable acids and complexes thereof. Furthermore the invention relates to a process for preparing these compounds.The new gonadoliberin derivatives can be effectively used for the reproduction process of fish, birds and mammals.Type: GrantFiled: December 20, 1984Date of Patent: March 3, 1987Assignee: Innovacios Alap Kozponti Valto Es Hitelbank RT.Inventors: Tamas Gulyas, Aniko Horvath, Gyorgy Keri, Karoly Nikolics, Balazs Szoke, Istvan Teplan
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Patent number: 4600705Abstract: The invention relates to novel gonadoliberine derivatives of the general formula (I) ##STR1## wherein X represents an --O--R group wherein R is a benzyl group or a C.sub.1-4 alkyl group, an ##STR2## group wherein R1 and R2 independently stand for hydrogen, a C.sub.1-5 alkyl, aryl, aryl-C.sub.1-2 -alkyl, morpholino, 1-indolinyl or 1-pyrrolidinyl group,Y is a glycine amide or a C.sub.1-4 -alkyl-amide group,the addition salts thereof formed with acids used in therapy and complexes thereof as well as pharmaceutical compositions containing them, furthermore to a process for the preparation of the above compounds.The reproductive processes of vertebrates can be advantageously influenced with the compounds of general formula (I).Type: GrantFiled: March 29, 1984Date of Patent: July 15, 1986Assignee: Richter Gedeon Veyteszeti Gyar R.T.Inventors: Janos Seprodi, Istvan Teplan, Imre Mezo, Judit rchegyi
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Patent number: 4552864Abstract: The invention relates to new gonadoliberin derivatives of the formula (I)Glp-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Y, (I)whereinY represents a glycine-amide group or an -NH-alkyl group having 1 to 4 carbon atoms in the alkyl moiety,X stands for a D-thyroxyl, D-thyronyl or D-4-chlorophenylalanyl group,and acid addition salts and metal complexes thereof.The new nona- and decapeptide derivatives have an excellent luteinizing and folliculus stimulating hormone releasing activity, and they can therefore be used as active ingredients in pharmaceutical compositions for human or veterinary application.Type: GrantFiled: May 4, 1984Date of Patent: November 12, 1985Assignee: Reanal FinomvegyszergyarInventors: Ferenc Antoni, Judit Erchegyi, Aniko Horvath, Gyorgi Keri, Imre Mezo, Karoly Nikolics, Janos Seprodi, Andras Szell, Balazs Szoke, Istvan Teplan