Patents by Inventor Istvan Tombacz

Istvan Tombacz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vivo targeting of T cells for mRNA therapeutics
    Publication number: 20230312713
    Abstract: The present invention relates to compositions comprising a delivery vehicle conjugated to a T cell targeting domain, wherein the delivery vehicle comprises at least one agent, and wherein the targeting domain specifically binds to a T cell antigen. The invention also relates to methods of treating or preventing diseases and disorders, including cancers, infectious diseases, and immunological disorders, using the described compositions.
    Type: Application
    Filed: October 13, 2021
    Publication date: October 5, 2023
    Inventors: Hamideh Parhiz, Drew Weissman, Istvan Tombacz
  • In vivo targeting of CD4+-T cells for mRNA therapeutics
    Publication number: 20230233706
    Abstract: The present invention relates to compositions comprising a delivery vehicle conjugated to a targeting domain, wherein the delivery vehicle comprises at least one agent, and wherein the targeting domain specifically binds to an CD4+ T cell antigen. The invention also relates to methods of treating or preventing diseases and disorders, including cancers, infectious diseases, and immunological disorders, using the described compositions.
    Type: Application
    Filed: October 13, 2021
    Publication date: July 27, 2023
    Inventors: Hamideh Parhiz, Drew Weissman, Istvan Tombacz, Norbert Pardi, Vladimir Muzykantov
  • In vivo targeting of Fibrosis by anti-CD5-targeted FAP-CAR T mRNA-LNP
    Publication number: 20230203538
    Abstract: The present invention relates to compositions and methods for T cell targeted delivery of nucleoside modified mRNA molecules encoding agents for the treatment and prevention of fibrosis, cardiac disease, and diseases and disorders associated therewith.
    Type: Application
    Filed: October 7, 2022
    Publication date: June 29, 2023
    Inventors: Hamideh Parhiz, Drew Weissman, Jonathan Epstein, Istvan Tombacz, Joel Rurik, Haig Aghajanian