Abstract: Methods and apparatus for cloud-based data management and reporting for bioprocess development. The system for process data management disclosed herein includes memory and processor circuitry to execute machine readable instructions to at least retrieve a first data set from at least one of an electronic laboratory notebook or a first laboratory device, retrieve a second data set from a second laboratory device, link the first data set and the second data set to a project, the first data and the second data set linked to the project based on a type of data in the first data set and the second data set, generate a data overlay using the first data set and the second data set, the data overlay including an overlay of a first chromatogram and a second chromatogram and generate a report including the data overlay.

Abstract: This invention relates to an immunogenic agent comprising a hydrophobic peptide covalently coupled or conjugated to at least one antigenic molecule that facilitates self-assembly of a plurality of the immunogenic agents into an immunogenic complex that has adjuvant properties. The invention also relates to a method of eliciting an immune response in a subject, comprising the step of administering to the subject at least one immunogenic agent or at least one immunogenic complex to thereby elicit an immune response in the subject.

Abstract: A cylinder head for an internal combustion engine with at least one cylinder has a cooling duct system which has a coolant inlet side and a coolant outlet side, a combustion chamber section, two coolant-inlet-side gas ducts, two coolant-outlet-side gas ducts and two adjacent component openings, such as a spark plug opening and an injection nozzle opening. The cylinder head has an annular wall section provided between the component openings, on the one hand, and the gas ducts, on the other hand. The cooling duct system has a web cooling duct which runs into the annular wall section, extends between the coolant-inlet-side gas ducts and has an upper wall. The upper wall has a guiding surface which is directed obliquely downwards in the region of the annular wall section in order to deflect coolant in the direction of the combustion chamber section.

Abstract: A cylinder head for an internal combustion engine with at least one cylinder has a cooling duct system which has a coolant inlet side and a coolant outlet side, a combustion chamber section, two coolant-inlet-side gas ducts, two coolant-outlet-side gas ducts and two adjacent component openings, such as a spark plug opening and an injection nozzle opening. The cylinder head has an annular wall section provided between the component openings, on the one hand, and the gas ducts, on the other hand. The cooling duct system has a web cooling duct which runs into the annular wall section, extends between the coolant-inlet-side gas ducts and has an upper wall. The upper wall has a guiding surface which is directed obliquely downwards in the region of the annular wall section in order to deflect coolant in the direction of the combustion chamber section.

Abstract: This invention relates to derivatives of an endomorphin, or of an endomorphin analog, comprising at least one moiety selected from a lipid moiety, a cyclitol moiety and a saccharide moiety.

Abstract: An apparatus for the installation of an elevator includes at least one suspension element fixed to the upper part of the elevator shaft, to which element is fitted a suspension device used to support shaft equipment during installation. The suspension device is mounted on the suspension element using a mounting tool from top floor landing.

Abstract: A composition for interacting with a ligand, which composition comprises a non-covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group, wherein the tail groups of the conjugates form a hydrophobic aggregation and the conjugates are movable within the association so that, in the presence of a ligand, at least two of the head groups are appropriately positioned to form an epitope capable of interacting with the ligand more strongly than each of head groups individually.

Abstract: A method for producing and using in treatment a composition for interacting with a ligand, which composition comprises a non-covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group, wherein the tail groups of the conjugates form a hydrophobic aggregation and the conjugates are movable within the association so that, in the presence of a ligand, at least two of the head groups are appropriately positioned to form an epitope capable of interacting with the ligand more strongly than each of the head groups individually.

Abstract: The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.

Abstract: Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing ?-amino acyl groups, preferably joined to the focal group, are used to assist transfection of cells in vitro and in vivo by DNA. The complex of dendrimer and DNA may be used in gene therapy, for instance to delivery clotting factor genes to cells.

Abstract: The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.

Abstract: This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.

Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.

Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.

Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.

Abstract: The invention provides amine-protecting groups for use in solution phase or solid-phase oligosaccharide synthesis, in which a 2-substituted 1,3-dioxo compound is used to protect one or more primary amine groups of an aminosugar or gylycosylamine. The invention provides reagents, reagent kits, and methods for solution phase, solid-phase oligosaccharide synthesis.

Abstract: The invention relates to a procedure and an apparatus for the installation of an elevator. According to the invention, at least one suspension element is fixed to the upper part of the elevator shaft, to which element is fitted a suspension device used to support shaft equipment during installation. The suspension device is mounted on the suspension element using a mounting tool from the top floor landing.

Abstract: The invention relates to a procedure and an apparatus for the installation of an elevator. According to the invention, at least one suspension element (16,17) is fixed to the upper part of the elevator shaft, to which element is fitted a suspension device (24) used to support shaft equipment during installation. The suspension device (24) is mounted on the suspension element (16,17) using a mounting tool (22) from the top floor landing (11).

Abstract: A dendritic compound comprises two dendrons, each comprising dendritically linked amino acid units, preferably lysine units, joined to a focal group. One of the dendrons includes terminal branches including anchor groups constituted by hydrophobic units and the second dendron has terminal branches which are linked or may be linked to active ligands or sugar moieties. Methods for synthesising the dendritic compounds using solid phase peptide synthetic techniques including lipidic amino acid reagents is described. The compounds serve as a basis for multiple antigenic peptides or drug delivery systems.

Abstract: The invention relates to a procedure and an apparatus intended to be used in elevator installation to install the overspeed governor (28) for the time it takes to install the elevator. According to the invention, when the elevator is being installed, at least one suspension element (17) is fastened to the upper part of the elevator shaft (2), an element (30) supporting the overspeed governor (28) is fitted to the suspension element and the position of the overspeed governor (28) at least in the vertical direction is so adjusted that it corresponds to the final placement of the overspeed governor (28). After the elevator guide rails (56) have been installed, the overspeed governor is removed from the suspension element (17) and fixed to a guide rail.