Patents by Inventor Istvan Toth

Istvan Toth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240221875
    Abstract: Methods and apparatus for cloud-based data management and reporting for bioprocess development. The system for process data management disclosed herein includes memory and processor circuitry to execute machine readable instructions to at least retrieve a first data set from at least one of an electronic laboratory notebook or a first laboratory device, retrieve a second data set from a second laboratory device, link the first data set and the second data set to a project, the first data and the second data set linked to the project based on a type of data in the first data set and the second data set, generate a data overlay using the first data set and the second data set, the data overlay including an overlay of a first chromatogram and a second chromatogram and generate a report including the data overlay.
    Type: Application
    Filed: April 29, 2022
    Publication date: July 4, 2024
    Inventors: Peter Andersson, Alexander Kele, Todd Ward, David Henderson, Vanessa Hoskins, Dean Whitney, Robin Modigh, Per LIDÉN, Olga Szaduro, Daniel Mynarski, Adam Sipos, Peter Cserna, David Birkas, Istvan Toth, Júlia Tünde GÁL, Hajnalka Albert, Zsofia Vasne Utassy, Edina Szava, Tim Bervoets
  • Publication number: 20230090311
    Abstract: This invention relates to an immunogenic agent comprising a hydrophobic peptide covalently coupled or conjugated to at least one antigenic molecule that facilitates self-assembly of a plurality of the immunogenic agents into an immunogenic complex that has adjuvant properties. The invention also relates to a method of eliciting an immune response in a subject, comprising the step of administering to the subject at least one immunogenic agent or at least one immunogenic complex to thereby elicit an immune response in the subject.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 23, 2023
    Inventors: Istvan TOTH, Mariusz SKWARCZYNSKI, Guangzu ZHAO
  • Patent number: 11542887
    Abstract: A cylinder head for an internal combustion engine with at least one cylinder has a cooling duct system which has a coolant inlet side and a coolant outlet side, a combustion chamber section, two coolant-inlet-side gas ducts, two coolant-outlet-side gas ducts and two adjacent component openings, such as a spark plug opening and an injection nozzle opening. The cylinder head has an annular wall section provided between the component openings, on the one hand, and the gas ducts, on the other hand. The cooling duct system has a web cooling duct which runs into the annular wall section, extends between the coolant-inlet-side gas ducts and has an upper wall. The upper wall has a guiding surface which is directed obliquely downwards in the region of the annular wall section in order to deflect coolant in the direction of the combustion chamber section.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: January 3, 2023
    Assignee: Bayerische Motoren Werke Aktiengesellschaft
    Inventor: Istvan Toth
  • Publication number: 20190178200
    Abstract: A cylinder head for an internal combustion engine with at least one cylinder has a cooling duct system which has a coolant inlet side and a coolant outlet side, a combustion chamber section, two coolant-inlet-side gas ducts, two coolant-outlet-side gas ducts and two adjacent component openings, such as a spark plug opening and an injection nozzle opening. The cylinder head has an annular wall section provided between the component openings, on the one hand, and the gas ducts, on the other hand. The cooling duct system has a web cooling duct which runs into the annular wall section, extends between the coolant-inlet-side gas ducts and has an upper wall. The upper wall has a guiding surface which is directed obliquely downwards in the region of the annular wall section in order to deflect coolant in the direction of the combustion chamber section.
    Type: Application
    Filed: February 19, 2019
    Publication date: June 13, 2019
    Inventor: Istvan TOTH
  • Publication number: 20100130581
    Abstract: This invention relates to derivatives of an endomorphin, or of an endomorphin analog, comprising at least one moiety selected from a lipid moiety, a cyclitol moiety and a saccharide moiety.
    Type: Application
    Filed: March 30, 2007
    Publication date: May 27, 2010
    Inventors: Istvan Toth, Yasuko Koda, Mark Pasqualino Del Borgo, Joanne Therese Blanchfield
  • Patent number: 7559409
    Abstract: An apparatus for the installation of an elevator includes at least one suspension element fixed to the upper part of the elevator shaft, to which element is fitted a suspension device used to support shaft equipment during installation. The suspension device is mounted on the suspension element using a mounting tool from top floor landing.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: July 14, 2009
    Assignee: Kone Corporation
    Inventors: Håkan Bärneman, Gert Van Der Meijden, Istvan Toth
  • Patent number: 7413538
    Abstract: A composition for interacting with a ligand, which composition comprises a non-covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group, wherein the tail groups of the conjugates form a hydrophobic aggregation and the conjugates are movable within the association so that, in the presence of a ligand, at least two of the head groups are appropriately positioned to form an epitope capable of interacting with the ligand more strongly than each of head groups individually.
    Type: Grant
    Filed: June 27, 2000
    Date of Patent: August 19, 2008
    Assignee: Mozaic Discovery Limited
    Inventors: Roger New, Istvan Toth
  • Publication number: 20080152703
    Abstract: A method for producing and using in treatment a composition for interacting with a ligand, which composition comprises a non-covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group, wherein the tail groups of the conjugates form a hydrophobic aggregation and the conjugates are movable within the association so that, in the presence of a ligand, at least two of the head groups are appropriately positioned to form an epitope capable of interacting with the ligand more strongly than each of the head groups individually.
    Type: Application
    Filed: March 4, 2008
    Publication date: June 26, 2008
    Applicant: Mozaic Discovery Limited
    Inventors: Roger NEW, Istvan TOTH
  • Patent number: 7312194
    Abstract: The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: December 25, 2007
    Assignee: Alchemia Pty. Ltd.
    Inventors: Istvan Toth, Robert Falconer, Shaun Emmanuel De Cruz, Ross Peter McGeary, Benjamin Paul Ross
  • Patent number: 7081495
    Abstract: Dendrimers comprising a dentritic polypeptide with one dendron having terminal cationic groups and a lipidic anchor, preferably comprising C6-24-alkyl group containing ?-amino acyl groups, preferably joined to the focal group, are used to assist transfection of cells in vitro and in vivo by DNA. The complex of dendrimer and DNA may be used in gene therapy, for instance to delivery clotting factor genes to cells.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: July 25, 2006
    Assignee: School of Pharmacy, University of London
    Inventors: Alexander T Florence, Andrew F Wilderspin, Istvan Toth, Henry K Bayele, Thiagarajan Sakthivel
  • Publication number: 20040176281
    Abstract: The invention relates to compounds which are useful in the delivery of a wide variety of therapeutically useful molecules. In particular, the invention relates to compounds which are able to act as carriers for therapeutically useful molecules, and to pharmaceutical agents comprising these carriers. The compounds of the invention comprise a mono- or oligosaccharide, a lipidic moiety, and optionally a linker and/or a spacer. The pharmaceutical agents of the invention are particularly useful for oral administration.
    Type: Application
    Filed: June 30, 2003
    Publication date: September 9, 2004
    Inventors: Istvan Toth, Robert Falconer, Shaun Emmanuel De Cruz, Ross Peter McGeary, Benjamin Paul Ross
  • Patent number: 6765089
    Abstract: This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: July 20, 2004
    Assignee: Alchemia Pty Ltd
    Inventors: Istvan Toth, Gyula Dekany, Barry Kellam
  • Patent number: 6723843
    Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: April 20, 2004
    Assignee: Alchemia PTY LTD
    Inventors: Istvan Toth, Gyula Dekany, Barry Kellam
  • Patent number: 6573337
    Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: June 3, 2003
    Assignee: Alchemia Pty LTD
    Inventors: Istvan Toth, Gyula Dekany, Barry Kellam
  • Publication number: 20030027925
    Abstract: The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to a polymer support. The invention provides reagents, reagent kits and methods for solid-phase oligosaccharide synthesis.
    Type: Application
    Filed: August 30, 2002
    Publication date: February 6, 2003
    Applicant: Alchemia Pty Ltd
    Inventors: Istvan Toth, Gyula Dekany, Barry Kellam
  • Patent number: 6462183
    Abstract: The invention provides amine-protecting groups for use in solution phase or solid-phase oligosaccharide synthesis, in which a 2-substituted 1,3-dioxo compound is used to protect one or more primary amine groups of an aminosugar or gylycosylamine. The invention provides reagents, reagent kits, and methods for solution phase, solid-phase oligosaccharide synthesis.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: October 8, 2002
    Assignee: Alchemia Pty Ltd
    Inventors: Istvan Toth, Gyula Dekany, Barry Kellam
  • Publication number: 20020066622
    Abstract: The invention relates to a procedure and an apparatus for the installation of an elevator. According to the invention, at least one suspension element is fixed to the upper part of the elevator shaft, to which element is fitted a suspension device used to support shaft equipment during installation. The suspension device is mounted on the suspension element using a mounting tool from the top floor landing.
    Type: Application
    Filed: January 24, 2002
    Publication date: June 6, 2002
    Applicant: KONE Corporation
    Inventors: Kakan Pettersson, Gert Van Der Meijden, Istvan Toth
  • Patent number: 6357556
    Abstract: The invention relates to a procedure and an apparatus for the installation of an elevator. According to the invention, at least one suspension element (16,17) is fixed to the upper part of the elevator shaft, to which element is fitted a suspension device (24) used to support shaft equipment during installation. The suspension device (24) is mounted on the suspension element (16,17) using a mounting tool (22) from the top floor landing (11).
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: March 19, 2002
    Assignee: Kone Corporation
    Inventors: Håkan Pettersson, Gert Van Der Meijden, Istvan Toth
  • Patent number: 6194543
    Abstract: A dendritic compound comprises two dendrons, each comprising dendritically linked amino acid units, preferably lysine units, joined to a focal group. One of the dendrons includes terminal branches including anchor groups constituted by hydrophobic units and the second dendron has terminal branches which are linked or may be linked to active ligands or sugar moieties. Methods for synthesising the dendritic compounds using solid phase peptide synthetic techniques including lipidic amino acid reagents is described. The compounds serve as a basis for multiple antigenic peptides or drug delivery systems.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: February 27, 2001
    Assignee: The school of Pharmacy University
    Inventors: Alexander T. Florence, Thiagarajan Sakthivel, Andrew F. Wilderspin, Istvan Toth
  • Patent number: 6138797
    Abstract: The invention relates to a procedure and an apparatus intended to be used in elevator installation to install the overspeed governor (28) for the time it takes to install the elevator. According to the invention, when the elevator is being installed, at least one suspension element (17) is fastened to the upper part of the elevator shaft (2), an element (30) supporting the overspeed governor (28) is fitted to the suspension element and the position of the overspeed governor (28) at least in the vertical direction is so adjusted that it corresponds to the final placement of the overspeed governor (28). After the elevator guide rails (56) have been installed, the overspeed governor is removed from the suspension element (17) and fixed to a guide rail.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: October 31, 2000
    Assignee: Kone Corporation
    Inventors: H.ang.kan Pettersson, Mark Peacock, Istvan Toth