Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.

Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.

Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.

Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.

Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.

Abstract: Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.

Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.

Abstract: Provided are fatty acid amides of amino acids, uses thereof and pharmaceutical compositions including them.

Abstract: Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.

Abstract: Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.

Abstract: The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.

Abstract: Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

Abstract: The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.

Abstract: Novel methods and pharmaceutical compositions suitable for modulating bone growth and remodeling, preventing bone diseases, inducing bone growth or repair by cannabinoid receptor-mediated effects on bone cells is disclosed. Methods of identifying bone growth modulating agents are also disclosed.

Abstract: The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.

Abstract: Cyclic to Synthetic pseudopeptide derivatives of osteogenic growth polypeptide (OGP) and OGP(10-14) which are capable of enhancing bone cell proliferation and bone formation. Pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

Abstract: The invention relates to synthetic pseudopeptide derivatives of osteogenic grog polypeptide (OGP) and OGP(10-14) which may be linear or cyclic, and which are capable of enhancing bone cell proliferation and bone formation. Further, the present invention relates to pharmaceutical composition comprising as active ingredient at least one pseudopeptide derivative of the invention and to the use of these pseudopeptide derivatives in the preparation of a pharmaceutical composition for stimulating the formation of osteoblastic or fibroblastic cells, enhancing bone formation in osteopenic pathological conditions, repairing fractures, healing wounds, grafting of intraosseous implants, reversing bone loss in osteoporosis and other conditions requiring enhanced bone cells formation.

Abstract: A device and method for the detection of smooth surface lesions such as caries and tooth crown surface cracks on a tooth crown surface, the device having an ultrasonic surface wave transmitter/receiver comprising a focused ultrasonic surface waves along a tooth crown surface. Surface lesions encountered by the ultrasonic surface waves produce ultrasonic surface wave reflections which are receivable at the generator/receiver, thus enabling the presence of the lesion, and particularly small lesions, to be detected. The ultrasonic surface wave generator/receiver may comprise a focused transducer, having a focusing element integral therewith or separate therefrom, operatively connected to a wedge-like coupler. Longitudinal ultrasonic waves generated by the transducers are at least partially focused by the focusing element and then imparted onto the tooth surface by the coupler which has a contact surface in contact with the tooth surface being tested.

Abstract: This invention is a device and method for the detection of smooth surface lesions such as caries and tooth crown surface cracks on a tooth crown surface, the device having an ultrasonic surface wave transmitter/receiver (20) capable of transmitting ultrasonic surface waves along a tooth crown surface. Surface lesions encountered by the ultrasonic surface waves produce ultrasonic surface wave reflections which are receivable at the generator/receiver, thus enabling the presence of the lesion to be detected. The ultrasonic surface wave generator/receiver may comprise a transducer operatively connected to a wedge-like coupler (30). Longitudinal ultrasonic waves generated by the transducer are imparted onto the tooth surface by the coupler which has a contact surface in contact with the tooth surface being tested. The coupler also enables ultrasonic surface wave reflections to be received by the transducer.

Abstract: A device for the detection of smooth surface lesions of dental caries on a tooth crown surface, having an ultrasonic transducer for transmitting ultrasonic waves and receiving ultrasonic wave reflections produced by lesions present on the surface, and an interface operatively connected to the transducer. The interface has a contact surface forming an angle .alpha. with a longitudinal axis of the ultrasonic transducer, where .alpha. is substantially different from 90.degree.. When the contact surface is in at least partial contact with a tooth crown surface at the longitudinal axis, ultrasonic waves generated by the ultrasonic transducer are imparted by the interface onto the tooth crown surface as surface ultrasonic waves which migrate along the tooth crown surface. Any lesions present on the tooth crown surface are then identifiable as surface ultrasonic wave reflections produced thereat.