Patents by Inventor Itai Benhar
Itai Benhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230312745Abstract: A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.Type: ApplicationFiled: June 7, 2023Publication date: October 5, 2023Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Ranit KEDMI, Nuphar VEIGA, Itai BENHAR, Dan PEER
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Patent number: 11708421Abstract: A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.Type: GrantFiled: July 18, 2017Date of Patent: July 25, 2023Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Ranit Kedmi, Nuphar Veiga, Itai Benhar, Dan Peer
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Publication number: 20230053258Abstract: Isolated anti-IDE antibodies are provided. Each of the antibodies comprise an antigen recognition domain comprising the indicated CDR amino acid sequences. Methods of producing same, methods of using same, pharmaceutical compositions comprising same and articles of manufacture are also provided.Type: ApplicationFiled: December 10, 2020Publication date: February 16, 2023Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Itai BENHAR, Limor NAHARY, Dan FRENKEL, Ofir FURSHT, Yuval NASH, Mirit LIRAN
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Publication number: 20220251193Abstract: Antibodies comprising an antigen recognition region which binds a semaphorin 3A (Sema3A) are disclosed. Uses thereof are also disclosed.Type: ApplicationFiled: June 25, 2020Publication date: August 11, 2022Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Itai BENHAR, Arieh S. SOLOMON, Ari BARZILAI, Limor NAHARY, Anat NITZAN, Mary SAFRIN, Marina BRUZEL, Ronit GALRON
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Patent number: 10822428Abstract: An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain. Methods of generating same and uses thereof are also provided.Type: GrantFiled: March 2, 2017Date of Patent: November 3, 2020Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Itai Benhar, Lilach Vaks
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Publication number: 20190309087Abstract: A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.Type: ApplicationFiled: July 18, 2017Publication date: October 10, 2019Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Ranit KEDMI, Nuphar VEIGA, Itai BENHAR, Dan PEER
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Patent number: 9925275Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].Type: GrantFiled: July 24, 2017Date of Patent: March 27, 2018Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD., RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Itai Benhar, Nir Osherov, Vladimir Dergachev, Alex Martin Szpilman
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Publication number: 20170319705Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].Type: ApplicationFiled: July 24, 2017Publication date: November 9, 2017Inventors: Itai BENHAR, Nir OSHEROV, Vladimir DERGACHEV, Alex Martin SZPILMAN
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Patent number: 9750817Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].Type: GrantFiled: August 15, 2016Date of Patent: September 5, 2017Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Itai Benhar, Nir Osherov, Vladimir Dergachev, Alex Martin Szpilman
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Publication number: 20170174791Abstract: An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain. Methods of generating same and uses thereof are also provided.Type: ApplicationFiled: March 2, 2017Publication date: June 22, 2017Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Itai BENHAR, Lilach VAKS
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Patent number: 9624291Abstract: An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain.Type: GrantFiled: March 15, 2012Date of Patent: April 18, 2017Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Itai Benhar, Lilach Vaks
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Publication number: 20170043029Abstract: Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal activity against multiple clinical fungal isolates. Derivatives of AMB are provided comprising a polymer group having an amine group, the polymer linked to mycosamine via a relatively stable linker such as an amide linker. The derivatives may be of the general formula [I]: wherein R is H, C1-4 alkyl or phenyl; R2 is (CH2)m wherein m is between 0 and 4; R3 and R4 are each independently H or C1-4 alkyl, R5 is H or OH, R6 is selected from a group consisting of: amide and alkyl, and R7 is a water-soluble polymer, and pharmaceutically acceptable salts, solvates, hydrates, diastereomers, and prodrugs of the compound of Formula [I].Type: ApplicationFiled: August 15, 2016Publication date: February 16, 2017Inventors: Itai BENHAR, Nir OSHEROV, Vladimir DERGACHEV, Alex Martin SZPILMAN
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Patent number: 9321847Abstract: The present invention relates to activatable toxin complexes which include a cleavable inhibitory peptide. More specifically, the complexes comprise a cell targeting domain, a toxin catalytic domain, a specific protease cleavage site and an inhibitory peptide domain. The inhibitory peptide prevents the catalytic domain from exerting toxic effects until its release from the complex by the action of a protease, such a viral protease, at the protease cleavage site. Further provided are pharmaceutical compositions comprising the complexes and use thereof for treating infections and malignant disease.Type: GrantFiled: August 22, 2011Date of Patent: April 26, 2016Assignee: RAMOT at Tel Aviv University Ltd.Inventors: Itai Benhar, Assaf Shapira, Meital Gal-Tanamy, Dana Greenfeld, Limor Nahary, Romy Zemel, Ran Tur-Kaspa
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Publication number: 20160108434Abstract: An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed.Type: ApplicationFiled: October 12, 2015Publication date: April 21, 2016Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: Iftach YACOBY, Ehud GAZIT, Nathan NELSON, Itai BENHAR
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Patent number: 9181555Abstract: An isolated polypeptide comprising a hydrogen generating enzyme attached to a heterologous ferredoxin is disclosed, as well as polynucleotides encoding same, nucleic acid constructs capable of expressing same and cells expressing same. A method for generating hydrogen using the isolated polypeptide is also disclosed.Type: GrantFiled: July 23, 2008Date of Patent: November 10, 2015Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Iftach Yacoby, Ehud Gazit, Nathan Nelson, Itai Benhar
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Patent number: 8741598Abstract: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.Type: GrantFiled: October 17, 2013Date of Patent: June 3, 2014Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Nathan Nelson, Iftach Yacoby, Ehud Gazit, Itai Benhar
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Publication number: 20140106428Abstract: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.Type: ApplicationFiled: October 17, 2013Publication date: April 17, 2014Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Nathan NELSON, Iftach Yacoby, Ehud Gazit, Itai Benhar
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Publication number: 20140010814Abstract: An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain.Type: ApplicationFiled: March 15, 2012Publication date: January 9, 2014Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Itai Benhar, Lilach Vaks
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Patent number: 8597655Abstract: The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.Type: GrantFiled: September 22, 2011Date of Patent: December 3, 2013Assignees: Ramot at Tel-Aviv University Ltd., The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical CenterInventors: Itay Barnea, Itai Benhar, Rahamim Ben-Yosef, Akiva Vexler
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Patent number: 8563294Abstract: A cyanobacterial cell comprising a PSI complex which accepts electrons from at least one respiratory cytochrome is disclosed. Methods of generating same and use of same for the production of hydrogen gas are also disclosed.Type: GrantFiled: May 26, 2010Date of Patent: October 22, 2013Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Nathan Nelson, Iftach Yacoby, Ehud Gazit, Itai Benhar