Abstract: The invention provides an endoscopic imaging photodynamic therapy system (EIPS) for focused tissue ablation by illumination of a photosensitizer drug in a target tissue, said system comprising an endoscopic assembly, a real-time imaging component for locating the target tissue and monitoring the ablation intervention, a therapeutic light system and, optionally, a drug delivery module, wherein said imaging component comprises a flexible transducer with an operative channel for insertion of a flexible light guide of the therapeutic light system and, optionally, a flexible drug delivery catheter of the drug delivery module. This EIPS may be used in various medical applications where tissue ablation is required and photodynamic therapy may be applied, in particular, in the treatment of extrauterine pregnancy (EUP).