Patents by Inventor Itaru Kushima

Itaru Kushima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fasudil for the treatment of schizophrenia
    Patent number: 11478482
    Abstract: The present invention provides an antipsychotic drug comprising fasudil or a pharmaceutically acceptable salt thereof as an active agent for the treatment of schizophrenia, including schizophrenia caused by dysfunction of ARHGAP10.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: October 25, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIG
    Inventors: Norio Ozaki, Kiyofumi Yamada, Taku Nagai, Daisuke Mori, Yuko Arioka, Itaru Kushima
  • ANTIPSYCHOTIC AND USE THEREOF
    Publication number: 20220152040
    Abstract: An object of the present invention is to provide a novel therapeutic agent for a mental disorder with abnormal neurodevelopment as a pathological condition. The present invention provides an antipsychotic drug containing a Rho kinase inhibitor as an active ingredient. The antipsychotic drug can be used, for example, in the treatment of schizophrenia, autism spectrum disorder, bipolar disorder, or depression.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 19, 2022
    Inventors: Norio OZAKI, Kiyofumi Yamada, Taku Nagai, Daisuke Mori, Yuko Arioka, Itaru Kushima
  • ANTIPSYCHOTIC AND USE THEREOF
    Publication number: 20210386755
    Abstract: An object of the present invention is to provide a novel therapeutic agent for a mental disorder with abnormal neurodevelopment as a pathological condition. The present invention provides an antipsychotic drug containing a Rho kinase inhibitor as an active ingredient. The antipsychotic drug can be used, for example, in the treatment of schizophrenia, autism spectrum disorder, bipolar disorder, or depression.
    Type: Application
    Filed: September 10, 2019
    Publication date: December 16, 2021
    Inventors: Norio OZAKI, Kiyofumi YAMADA, Taku NAGAI, Daisuke MORI, Yuko ARIOKA, Itaru KUSHIMA
  • METHOD FOR PRODUCING DOPAMINERGIC NEURONS
    Publication number: 20210123017
    Abstract: An object of the present invention is to provide a method for preparing dopamine neurons efficiently in a short period of time. The dopamine neuron is prepared by step of culturing pluripotent stem cells in the presence of a TGF-? family inhibitor, a GSK3? inhibitor, and a BMP inhibitor; step of suspension-culturing the cells obtained in step in the presence of a TGF-? family inhibitor, a GSK3? inhibitor, FGF8, and a hedgehog signal agonist and under normal oxygen partial pressure to form a neurosphere; and step of collecting the neurosphere to induce differentiation of the cells into dopamine neurons.
    Type: Application
    Filed: April 11, 2018
    Publication date: April 29, 2021
    Inventors: Norio Ozaki, Yuko Arioka, Daisuke Mori, Itaru Kushima
  • DRUG EVALUATION METHOD
    Publication number: 20200408743
    Abstract: An object of the present invention is to provide a novel evaluation system that is particularly useful in researches on the onset mechanism and pathologic conditions of a central nervous system disease, development of a therapeutic method, or the like. The efficacy of a test substance is evaluated using a movement pattern defined by variations in movement of individual cells constituting a cell population as an index.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 31, 2020
    Applicant: NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
    Inventors: Norio Ozaki, Yuko Arioka, Emiko Higashijima, Daisuke Mori, Itaru Kushima