Patents by Inventor Itaru Shigehara
Itaru Shigehara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5763439Abstract: A pyridazinone derivative of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein Q, A, and R.sup.1 -R.sup.4 are as defined herein, useful as an anti-shock agent.Type: GrantFiled: March 4, 1996Date of Patent: June 9, 1998Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Itaru Shigehara, Shinji Odawara, Hiroshi Okada, Hirohiko Kimura, Masato Omatsu, Hitoshi Nakayama, Rie Higuchi, Taki Takenami
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Patent number: 5492908Abstract: A method of treating rheumatoid arthritis using a diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted as further defined herein.Type: GrantFiled: August 3, 1994Date of Patent: February 20, 1996Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
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Patent number: 5436267Abstract: A novel N-phenylcarbamate compound or its salt where possible, which is useful as the active ingredient of a biocidal composition for control of harmful organisms, is represented by the following general formula (I): ##STR1## wherein R.sup.1 is unsubstituted or substituted alkyl; R.sup.2 is H, unsubstituted or substituted alkyl, alkenyl, alkynyl or cycloalkyl, or --COX.sup.1 wherein X.sup.1 is unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl or alkoxy; Z is --CH.sub.2 S--, --SCH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 SO--, --CH.sub.2 SO.sub.2 --, --CH.sub.2 SCH.sub.2 --, or --CH.sub.2 O--N.dbd.C(R.sup.4)--; R.sup.Type: GrantFiled: July 11, 1994Date of Patent: July 25, 1995Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Terumasa Komyoji, Itaru Shigehara, Norifusa Matsuo, Hiroshi Shimoharada, Takeshi Ohshima, Toshio Akagi, Shigeru Mitani
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Patent number: 5348967Abstract: A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, as defined herein.Type: GrantFiled: March 23, 1993Date of Patent: September 20, 1994Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
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Patent number: 5260320Abstract: A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted, each of R.sup.2 and R.sup.7, which are independent from each other, is alkyl which may be substituted, alkoxy which may be substituted, phenyl which may be substituted or phenoxy which may be substituted, each of R.sup.Type: GrantFiled: July 29, 1992Date of Patent: November 9, 1993Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
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Patent number: 5229403Abstract: A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1 (W.sup.2 W.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted, each of R.sup.2 and R.sup.7, which are independent from each other, is alkyl which may be substituted, alkoxy which may be substituted, phenyl which may be substituted or phenoxy which may be substituted, each of R.sup.Type: GrantFiled: June 28, 1991Date of Patent: July 20, 1993Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
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Patent number: 5023336Abstract: An imidazole compound is disclosed, which is represented by formula (I): ##STR1## wherein: X represents a --COOT group, in which T represents a hydrogen atom, an alkyl group, a benzyl group, or a phenyl group; or a --CONH.sub.2 group,Y represents a hydrogen atom, a chlorine atom, or a bromine atom,Z represents an alkyl group containing from 2 to 6 carbon atoms, which may be substituted with one or more halogen atoms; or a phenyl group which may be substituted with one or more halogen atoms or alkyl groups, andQ represents a hydrogen atom; an --SO.sub.2 R.sup.1 group, in which R.sup.1 represents an alkyl group, a dialkylamino group, or a phenyl group which may be substituted with one or more alkyl groups; or a --CH(R.sup.2)(R.sup.3) group, in which R.sup.2 represents a hydrogen atom, a methyl group, or an alkoxy group, and R.sup.3 represents an alkoxy group, an --OCH.sub.2 CH.sub.2 Si (CH.sub.Type: GrantFiled: October 20, 1989Date of Patent: June 11, 1991Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Itaru Shigehara, Toshio Nakajima, Shigeyuki Nishimura, Takeshi Ohshima
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Patent number: 4861886Abstract: A method for isomerization of trans-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof, which comprises isomerizing said trans-form quinuclidine or acid addition salts thereof to cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof in the presence of at least one acid catalyst selected from the group consisting of an organic sulfuric acid, a halide functioning as a Lewis acid, and sulfuric acid.Type: GrantFiled: July 6, 1988Date of Patent: August 29, 1989Assignee: Ishahara Sangyo Kaisha LtdInventors: Takahiro Haga, Itaru Shigehara, Toru Koyanagi, Kazutoshi Hara, Masaru Maeda
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Patent number: 4490534Abstract: A process for producing a 3-chloro-5-trifluoromethylpyridine derivative comprises reacting a 5-trifluoromethylpyridine derivative having a hydrogen atom at 3-position with chlorine. The process is characterized by reacting said 5-trifluoromethylpyridine derivative with chlorine in a vapor phase in the presence of a catalyst selected from the group consisting of activated carbon and a chloride of a metal element selected from the group consisting of iron, antimony, copper and zinc.Type: GrantFiled: October 14, 1982Date of Patent: December 25, 1984Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Kanichi Fujikawa, Yasuhiro Tsujii, Itaru Shigehara, Tatsuo Isogai, Hiroshi Yoshizawa, Mikio Miyaji
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Patent number: 4380670Abstract: An aminobenzene is produced by reacting a chlorobenzene with ammonia in the presence of a copper type catalyst, namely by reacting ammonia with 3,5-diaminochlorobenzene to produce 1,3,5-triaminobenzene at a temperature of 150.degree. to 250.degree. C. at a molar ratio of ammonia of 2 to 10 to 3,5-diaminochlorobenzene in the presence of a copper compound catalyst.Type: GrantFiled: April 3, 1981Date of Patent: April 19, 1983Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Mikio Miyaji
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Patent number: 4368340Abstract: 1,3,5,-Trichlorobenzene is produced by chlorinating 1,3,5-trihalobenzene having 1 to 3 bromine atom and 2 to 0 chlorine atom. The gaseous 1,3,5-halobenzene having 1 to 3 bromine atom and 2 to 0 chlorine atom is brought into contact with chlorine gas at a molar ratio of 0.5 to 3.0 of the stoichiometric amount of chlorine required for said conversion, in a vapor phase at a temperature of 280.degree. to 500.degree. C.Type: GrantFiled: December 4, 1980Date of Patent: January 11, 1983Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Mikio Miyaji
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Patent number: 4347390Abstract: 1-Bromo-3,5-dichlorobenzene is produced in high efficiency by a special isomerization of monobromodichlorobenzene in the presence of an aluminum halide and separating the object product and recycling a residue.1-Bromo-3,5-dichlorobenzene is useful intermediates for various agricultural chemicals, dyes and medicines.Type: GrantFiled: November 13, 1980Date of Patent: August 31, 1982Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Yasuhiro Tsujii, Itaru Shigehara, Kuniaki Nagatani, Shigeyuki Nishimura
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Patent number: 4267336Abstract: 4-(Pyridyl-2-oxy)phenoxyalkanecarboxylic acid derivative is produced by reacting 2-phenoxypyridine derivative with 4-hydroxyphenoxyalkanecarboxylic acid derivative. The products which are effective as an active ingredient of a herbicide can be obtained at high yield by an interphenoxylation.Type: GrantFiled: April 7, 1980Date of Patent: May 12, 1981Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Rikuo Nasu, Itaru Shigehara
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Patent number: 4230642Abstract: 1-Bromo-3,5-dichlorobenzene is reacted with magnesium in a solvent and acetone is added to react it with the reaction product and a mineral acid is added to hydrolyze the resulting .alpha.-(3,5-dichlorophenyl) isopropoxymagnesium bromide and then, the product is dehydrated to obtain 3,5-dichloro-.alpha.-methylstyrene. 3,5-Dichloro-.alpha.-methylstyrene is useful intermediate for various agricultural chemicals, medicines and dyes and also useful monomer for rubbers, plastics and resins.Type: GrantFiled: February 2, 1979Date of Patent: October 28, 1980Assignee: Ishihara Sangyo Kaisha LimitedInventors: Ryuzo Nishiyama, Kanichi Fujikawa, Yasuhiro Tsujii, Itaru Shigehara
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Patent number: 4203758Abstract: A herbicide which comprises a compound as an active ingredient having the formula ##STR1## wherein X represents --H or --Cl; Y represents halogen atom or cyano group; Z.sub.1 represents --H or methyl group; Z.sub.2 represents --H, methyl or ethyl group; Z.sub.3 represents cyano group or ##STR2## group; R represents hydroxy group, --O-- cation group, C.sub.1 -C.sub.4 alkylthio group, C.sub.2 -C.sub.4 alkenylthio group, C.sub.2 -C.sub.4 alkynylthio group, C.sub.1 -C.sub.4 alkoxy group, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkoxy group, C.sub.2 -C.sub.4 alkenyloxy group, C.sub.2 -C.sub.4 alkynyloxy group, amino group, C.sub.1 -C.sub.4 alkylamino group, di-C.sub.1 -C.sub.4 alkylamino group or anilino group which can be substituted with halogen atom or C.sub.1 -C.sub.4 alkyl group.Type: GrantFiled: September 29, 1977Date of Patent: May 20, 1980Assignee: Ishihara Sangyo Kaisha LimitedInventors: Ryuzo Nishiyama, Ryohei Takahashi, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Nobuyuki Sakashita
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Patent number: 4134751Abstract: Phenoxy valeric acids and derivatives thereof represented by the general formula (I): ##STR1## wherein X is a hydrogen atom or a chlorine atom; and R is a hydroxy group, an --O-cation group, a (C.sub.1 - C.sub.4)alkoxy group, a (C.sub.1 - C.sub.4)alkylthio group, a benzyloxy group, or an amino group which may be substituted with a (C.sub.1 - C.sub.4)alkyl group(s), a phenyl group or a pyridine-2-yl group, useful as a herbicide; a herbicidal composition containing the compound; and methods of controlling weeds using such materials.Type: GrantFiled: April 14, 1977Date of Patent: January 16, 1979Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Rikuo Nasu, Itaru Shigehara, Nobuyuki Sakashita
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Patent number: 4070177Abstract: A herbicide which comprises a compound as an active ingredient having the formula ##STR1## wherein X represents --H or --Cl; Y represents halogen atom or cyano group; Z.sub.1 represents --H or methyl group; Z.sub.2 represents --H, methyl or ethyl group; Z.sub.3 represents cyano group or ##STR2## group; R represents hydroxy group, --O-- cation group, C.sub.1 - C.sub.4 alkylthio group, C.sub.2 - C.sub.4 alkenylthio group, C.sub.2 - C.sub.4 alkynylthio group, C.sub.1 - C.sub.4 alkoxy group, C.sub.1 - C.sub.4 alkoxy- C.sub.1 - C.sub.4 alkoxy group, C.sub.2 - C.sub.4 alkenyloxy group, C.sub.2 - C.sub.4 alkynyloxy group, amino group, C.sub.1 - C.sub.4 alkylamino group, di-C.sub.1 - C.sub.4 alkylamino group or anilino group which can be substituted with halogen atom or C.sub.1 - C.sub.4 alkyl group.Type: GrantFiled: September 10, 1976Date of Patent: January 24, 1978Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryuzo Nishiyama, Ryohei Takahashi, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Nobuyuki Sakashita
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Patent number: 3969362Abstract: Compounds of the formula: ##SPC1##Wherein X represents chlorine or bromine have been found to be effective fungicides.Type: GrantFiled: April 28, 1975Date of Patent: July 13, 1976Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Ryohei Takahashi, Isao Yokomichi, Itaru Shigehara, Terumasa Komyoji