Patents by Inventor Itaru Shigehara

Itaru Shigehara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5763439
    Abstract: A pyridazinone derivative of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein Q, A, and R.sup.1 -R.sup.4 are as defined herein, useful as an anti-shock agent.
    Type: Grant
    Filed: March 4, 1996
    Date of Patent: June 9, 1998
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Itaru Shigehara, Shinji Odawara, Hiroshi Okada, Hirohiko Kimura, Masato Omatsu, Hitoshi Nakayama, Rie Higuchi, Taki Takenami
  • Patent number: 5492908
    Abstract: A method of treating rheumatoid arthritis using a diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted as further defined herein.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: February 20, 1996
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
  • Patent number: 5436267
    Abstract: A novel N-phenylcarbamate compound or its salt where possible, which is useful as the active ingredient of a biocidal composition for control of harmful organisms, is represented by the following general formula (I): ##STR1## wherein R.sup.1 is unsubstituted or substituted alkyl; R.sup.2 is H, unsubstituted or substituted alkyl, alkenyl, alkynyl or cycloalkyl, or --COX.sup.1 wherein X.sup.1 is unsubstituted or substituted alkyl, alkenyl, alkynyl, cycloalkyl or alkoxy; Z is --CH.sub.2 S--, --SCH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 SO--, --CH.sub.2 SO.sub.2 --, --CH.sub.2 SCH.sub.2 --, or --CH.sub.2 O--N.dbd.C(R.sup.4)--; R.sup.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: July 25, 1995
    Assignee: Ishihara Sangyo Kaisha, Ltd.
    Inventors: Terumasa Komyoji, Itaru Shigehara, Norifusa Matsuo, Hiroshi Shimoharada, Takeshi Ohshima, Toshio Akagi, Shigeru Mitani
  • Patent number: 5348967
    Abstract: A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, as defined herein.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: September 20, 1994
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
  • Patent number: 5260320
    Abstract: A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1)W.sup.2 R.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N(R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted, each of R.sup.2 and R.sup.7, which are independent from each other, is alkyl which may be substituted, alkoxy which may be substituted, phenyl which may be substituted or phenoxy which may be substituted, each of R.sup.
    Type: Grant
    Filed: July 29, 1992
    Date of Patent: November 9, 1993
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
  • Patent number: 5229403
    Abstract: A diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW.sup.1 R.sup.1, --COCOR.sup.2, --CW.sup.1 NHCOR.sup.2, --C(.dbd.W.sup.1 (W.sup.2 W.sup.3 or --CW.sup.1 N(R.sup.4)R.sup.5, and Y is alkyl, --CW.sup.3 R.sup.6, --COCOR.sup.7, --NHCOR.sup.7, --C(.dbd.W.sup.3)W.sup.4 R.sup.8, --(NH).sub.m SO.sub.2 R.sup.9, --(NH).sub.m SO.sub.2 OR.sup.10 or --(NH).sub.m SO.sub.2 N R.sup.11)R.sup.12, wherein each of R.sup.1, R.sup.6 and R.sup.9, which are independent from one another, is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted or a polycyclic heterocycle group which may be substituted, each of R.sup.2 and R.sup.7, which are independent from each other, is alkyl which may be substituted, alkoxy which may be substituted, phenyl which may be substituted or phenoxy which may be substituted, each of R.sup.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: July 20, 1993
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Takahiro Haga, Hideo Sugi, Itaru Shigehara, Shinji Odawara, Syuichi Yotsuya, Hirohiko Kimura, Kazuhiro Yamamoto
  • Patent number: 5023336
    Abstract: An imidazole compound is disclosed, which is represented by formula (I): ##STR1## wherein: X represents a --COOT group, in which T represents a hydrogen atom, an alkyl group, a benzyl group, or a phenyl group; or a --CONH.sub.2 group,Y represents a hydrogen atom, a chlorine atom, or a bromine atom,Z represents an alkyl group containing from 2 to 6 carbon atoms, which may be substituted with one or more halogen atoms; or a phenyl group which may be substituted with one or more halogen atoms or alkyl groups, andQ represents a hydrogen atom; an --SO.sub.2 R.sup.1 group, in which R.sup.1 represents an alkyl group, a dialkylamino group, or a phenyl group which may be substituted with one or more alkyl groups; or a --CH(R.sup.2)(R.sup.3) group, in which R.sup.2 represents a hydrogen atom, a methyl group, or an alkoxy group, and R.sup.3 represents an alkoxy group, an --OCH.sub.2 CH.sub.2 Si (CH.sub.
    Type: Grant
    Filed: October 20, 1989
    Date of Patent: June 11, 1991
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Itaru Shigehara, Toshio Nakajima, Shigeyuki Nishimura, Takeshi Ohshima
  • Patent number: 4861886
    Abstract: A method for isomerization of trans-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof, which comprises isomerizing said trans-form quinuclidine or acid addition salts thereof to cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or acid addition salts thereof in the presence of at least one acid catalyst selected from the group consisting of an organic sulfuric acid, a halide functioning as a Lewis acid, and sulfuric acid.
    Type: Grant
    Filed: July 6, 1988
    Date of Patent: August 29, 1989
    Assignee: Ishahara Sangyo Kaisha Ltd
    Inventors: Takahiro Haga, Itaru Shigehara, Toru Koyanagi, Kazutoshi Hara, Masaru Maeda
  • Patent number: 4490534
    Abstract: A process for producing a 3-chloro-5-trifluoromethylpyridine derivative comprises reacting a 5-trifluoromethylpyridine derivative having a hydrogen atom at 3-position with chlorine. The process is characterized by reacting said 5-trifluoromethylpyridine derivative with chlorine in a vapor phase in the presence of a catalyst selected from the group consisting of activated carbon and a chloride of a metal element selected from the group consisting of iron, antimony, copper and zinc.
    Type: Grant
    Filed: October 14, 1982
    Date of Patent: December 25, 1984
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Kanichi Fujikawa, Yasuhiro Tsujii, Itaru Shigehara, Tatsuo Isogai, Hiroshi Yoshizawa, Mikio Miyaji
  • Patent number: 4380670
    Abstract: An aminobenzene is produced by reacting a chlorobenzene with ammonia in the presence of a copper type catalyst, namely by reacting ammonia with 3,5-diaminochlorobenzene to produce 1,3,5-triaminobenzene at a temperature of 150.degree. to 250.degree. C. at a molar ratio of ammonia of 2 to 10 to 3,5-diaminochlorobenzene in the presence of a copper compound catalyst.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: April 19, 1983
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Mikio Miyaji
  • Patent number: 4368340
    Abstract: 1,3,5,-Trichlorobenzene is produced by chlorinating 1,3,5-trihalobenzene having 1 to 3 bromine atom and 2 to 0 chlorine atom. The gaseous 1,3,5-halobenzene having 1 to 3 bromine atom and 2 to 0 chlorine atom is brought into contact with chlorine gas at a molar ratio of 0.5 to 3.0 of the stoichiometric amount of chlorine required for said conversion, in a vapor phase at a temperature of 280.degree. to 500.degree. C.
    Type: Grant
    Filed: December 4, 1980
    Date of Patent: January 11, 1983
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Mikio Miyaji
  • Patent number: 4347390
    Abstract: 1-Bromo-3,5-dichlorobenzene is produced in high efficiency by a special isomerization of monobromodichlorobenzene in the presence of an aluminum halide and separating the object product and recycling a residue.1-Bromo-3,5-dichlorobenzene is useful intermediates for various agricultural chemicals, dyes and medicines.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: August 31, 1982
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Isao Yokomichi, Yasuhiro Tsujii, Itaru Shigehara, Kuniaki Nagatani, Shigeyuki Nishimura
  • Patent number: 4267336
    Abstract: 4-(Pyridyl-2-oxy)phenoxyalkanecarboxylic acid derivative is produced by reacting 2-phenoxypyridine derivative with 4-hydroxyphenoxyalkanecarboxylic acid derivative. The products which are effective as an active ingredient of a herbicide can be obtained at high yield by an interphenoxylation.
    Type: Grant
    Filed: April 7, 1980
    Date of Patent: May 12, 1981
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Rikuo Nasu, Itaru Shigehara
  • Patent number: 4230642
    Abstract: 1-Bromo-3,5-dichlorobenzene is reacted with magnesium in a solvent and acetone is added to react it with the reaction product and a mineral acid is added to hydrolyze the resulting .alpha.-(3,5-dichlorophenyl) isopropoxymagnesium bromide and then, the product is dehydrated to obtain 3,5-dichloro-.alpha.-methylstyrene. 3,5-Dichloro-.alpha.-methylstyrene is useful intermediate for various agricultural chemicals, medicines and dyes and also useful monomer for rubbers, plastics and resins.
    Type: Grant
    Filed: February 2, 1979
    Date of Patent: October 28, 1980
    Assignee: Ishihara Sangyo Kaisha Limited
    Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Yasuhiro Tsujii, Itaru Shigehara
  • Patent number: 4203758
    Abstract: A herbicide which comprises a compound as an active ingredient having the formula ##STR1## wherein X represents --H or --Cl; Y represents halogen atom or cyano group; Z.sub.1 represents --H or methyl group; Z.sub.2 represents --H, methyl or ethyl group; Z.sub.3 represents cyano group or ##STR2## group; R represents hydroxy group, --O-- cation group, C.sub.1 -C.sub.4 alkylthio group, C.sub.2 -C.sub.4 alkenylthio group, C.sub.2 -C.sub.4 alkynylthio group, C.sub.1 -C.sub.4 alkoxy group, C.sub.1 -C.sub.4 alkoxy-C.sub.1 -C.sub.4 alkoxy group, C.sub.2 -C.sub.4 alkenyloxy group, C.sub.2 -C.sub.4 alkynyloxy group, amino group, C.sub.1 -C.sub.4 alkylamino group, di-C.sub.1 -C.sub.4 alkylamino group or anilino group which can be substituted with halogen atom or C.sub.1 -C.sub.4 alkyl group.
    Type: Grant
    Filed: September 29, 1977
    Date of Patent: May 20, 1980
    Assignee: Ishihara Sangyo Kaisha Limited
    Inventors: Ryuzo Nishiyama, Ryohei Takahashi, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Nobuyuki Sakashita
  • Patent number: 4134751
    Abstract: Phenoxy valeric acids and derivatives thereof represented by the general formula (I): ##STR1## wherein X is a hydrogen atom or a chlorine atom; and R is a hydroxy group, an --O-cation group, a (C.sub.1 - C.sub.4)alkoxy group, a (C.sub.1 - C.sub.4)alkylthio group, a benzyloxy group, or an amino group which may be substituted with a (C.sub.1 - C.sub.4)alkyl group(s), a phenyl group or a pyridine-2-yl group, useful as a herbicide; a herbicidal composition containing the compound; and methods of controlling weeds using such materials.
    Type: Grant
    Filed: April 14, 1977
    Date of Patent: January 16, 1979
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Ryuzo Nishiyama, Kanichi Fujikawa, Rikuo Nasu, Itaru Shigehara, Nobuyuki Sakashita
  • Patent number: 4070177
    Abstract: A herbicide which comprises a compound as an active ingredient having the formula ##STR1## wherein X represents --H or --Cl; Y represents halogen atom or cyano group; Z.sub.1 represents --H or methyl group; Z.sub.2 represents --H, methyl or ethyl group; Z.sub.3 represents cyano group or ##STR2## group; R represents hydroxy group, --O-- cation group, C.sub.1 - C.sub.4 alkylthio group, C.sub.2 - C.sub.4 alkenylthio group, C.sub.2 - C.sub.4 alkynylthio group, C.sub.1 - C.sub.4 alkoxy group, C.sub.1 - C.sub.4 alkoxy- C.sub.1 - C.sub.4 alkoxy group, C.sub.2 - C.sub.4 alkenyloxy group, C.sub.2 - C.sub.4 alkynyloxy group, amino group, C.sub.1 - C.sub.4 alkylamino group, di-C.sub.1 - C.sub.4 alkylamino group or anilino group which can be substituted with halogen atom or C.sub.1 - C.sub.4 alkyl group.
    Type: Grant
    Filed: September 10, 1976
    Date of Patent: January 24, 1978
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Ryuzo Nishiyama, Ryohei Takahashi, Kanichi Fujikawa, Isao Yokomichi, Itaru Shigehara, Nobuyuki Sakashita
  • Patent number: 3969362
    Abstract: Compounds of the formula: ##SPC1##Wherein X represents chlorine or bromine have been found to be effective fungicides.
    Type: Grant
    Filed: April 28, 1975
    Date of Patent: July 13, 1976
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Ryohei Takahashi, Isao Yokomichi, Itaru Shigehara, Terumasa Komyoji