Patents by Inventor Itzhak Ofek

Itzhak Ofek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100303841
    Abstract: The subject invention provides new adjuvant therapy.
    Type: Application
    Filed: November 27, 2008
    Publication date: December 2, 2010
    Inventors: Nira Hochman, Jacob Hochman, Ervin Weiss, Itzhak Ofek
  • Patent number: 7435716
    Abstract: Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing same useful in the treatment of bacteremia and/or septicemia following infection by gram negative bacteria administered alone or in combination with conventional antibiotics.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: October 14, 2008
    Assignees: Ramot At Tel Aviv University Ltd., Yeda Research and Development Co. Ltd.
    Inventors: Itzhak Ofek, Matityahu Fridkin, Haim Tsubery
  • Patent number: 7390515
    Abstract: The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus Vaccinium. Two specific fractions are provided: (a) polymeric material having a molecular weight?12,000; and (b) proanthocyanidins-containing fraction. Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject. A specific and preferred viral infection according to the invention is an influenza virus infection.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: June 24, 2008
    Assignee: Ramot At Tel-Aviv University Ltd.
    Inventors: Ervin I. Weiss, Itzhak Ofek, Zichria Zakay-Rones, Yael Houri-Haddad
  • Publication number: 20050196472
    Abstract: The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus Vaccinium. Two specific fractions are provided: (a) polymeric material having a molecular weight ?12,000; and (b) proanthocyanidins-containing fraction. Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject. A specific and preferred viral infection according to the invention is an influenza virus infection.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 8, 2005
    Inventors: Ervin Weiss, Itzhak Ofek, Zichria Zakay-Rones, Yael Houri-Haddad
  • Patent number: 6843993
    Abstract: A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ?14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: January 18, 2005
    Assignee: Ramot at Tel-Aviv University, Ltd.
    Inventors: Itzhak Ofek, Ervin Weiss, Yoel Kashman, Janina Goldhar, Nathan Sharon
  • Publication number: 20040082505
    Abstract: Novel conjugates of bacterial outer membrane binding peptides, preferably having bacterial sensitization activity, and immune cells chemotactic peptides, and pharmaceutical compositions containing same useful in the treatment of bacteremia and/or septicemia following infection by gram negative bacteria administered alone or in combination with conventional antibiotics.
    Type: Application
    Filed: July 15, 2003
    Publication date: April 29, 2004
    Inventors: Itzhak Ofek, Matityahu Fridkin, Haim Tsubery
  • Publication number: 20020048611
    Abstract: A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.
    Type: Application
    Filed: July 27, 2001
    Publication date: April 25, 2002
    Inventors: Itzhak Ofek, Ervin Weiss, Yoel Kashman, Janina Goldhar, Nathan Sharon
  • Patent number: 6303125
    Abstract: A non-food anti-microbial-adhesion and aggregation composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In an embodiment the anti-aggregation and adhesion fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight ≧14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; a nuclear magnetic resonance (NMR) line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against P fimbriated bacteria, oral bacteria and Helicobacter pylori.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: October 16, 2001
    Assignee: RAMOT-University Authority for Applied Research and Industrial Development Ltd.
    Inventors: Itzhak Ofek, Ervin Weiss, Yoel Kashman, Janina Goldhar, Nathan Sharon
  • Patent number: 5840322
    Abstract: A non-food oral hygiene composition comprising a suitable carrier and an effective amount of an adhesion inhibitory fraction isolated from juice from berries of the Vaccinium plant genus. In a preferred embodiment the anti-aggregation fraction is isolated from cranberry juice. It is characterized as being polymeric and having a molecular weight .gtoreq.14,000; an elemental analysis of carbon 43-51%, hydrogen 4-5%, no nitrogen, no sulfur and no chlorine; an NMR line spectrum as set forth in FIGS. 2A and 2B; and an ultraviolet spectrum with an absorption peak at 280 nm in neutral or acidic pH solution which is absent in alkali solutions. This fraction exhibits adhesion inhibitory activity against both P fimbriated bacteria and oral bacteria.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: November 24, 1998
    Assignee: Ramot-University Authority For Applied Research & Industrial Devel. Ltd.
    Inventors: Ervin Weiss, Itzhak Ofek, Yoel Kashman, Janina Goldhar, Nathan Sharon