Patents by Inventor Ivan Borrello

Ivan Borrello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY
    Publication number: 20220257650
    Abstract: Marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor, resulting in a CAR-MIL.
    Type: Application
    Filed: November 27, 2019
    Publication date: August 18, 2022
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Ivan Borrello, Eric R. Lutz, Lakshmi Rudraraju, Srikanta Jana, Ido Weiss, Valentina Hoyos
  • Lung Cancer Specific Marrow Infiltrating Lymphocytes and Uses Thereof
    Publication number: 20220168350
    Abstract: Lung cancer specific marrow infiltrating lymphocytes (“MILs”) and methods for making and using the same are described. Disclosed herein is a method for treating a subject having lung cancer with marrow infiltrating lymphocytes, the method comprising the steps of: (a) culturing a bone marrow sample obtained from the subject having lung cancer with an anti-CD3 antibody and an anti-CD28 antibody in a hypoxic environment to produce hypoxic-activated marrow infiltrating lymphocytes; (b) culturing the hypoxic-activated marrow infiltrating lymphocytes in a normoxic environment to produce the therapeutic activated marrow infiltrating lymphocytes; and (c) administering the therapeutic activated marrow infiltrating lymphocytes to the subject having lung cancer.
    Type: Application
    Filed: March 20, 2020
    Publication date: June 2, 2022
    Applicants: WINDMIL THERAPEUTICS, INC., THE JOHNS HOPKINS UNIVERSITY
    Inventors: Kimberly A. Noonan, Ivan Borrello
  • MARROW INFILTRATING LYMPHOCYTES (MILs) EXPRESSING CHIMERIC ANTIGEN RECEPTORS (CAR), METHOD OF MANUFACTURING SAME, AND METHOD OF USING IN THERAPY
    Publication number: 20210154233
    Abstract: Marrow-infiltrating lymphocytes (“MILs”) comprising a chimeric antigen receptor (“CAR”) are provided. In some aspects, the embodiments relate to a method for making a recombinant MIL, comprising obtaining bone marrow comprising MILs; and transfecting, transforming, or transducing the MILs with a nucleic acid encoding a chimeric antigen receptor, resulting in a CAR-MIL. In some aspects, the embodiments relate to a method for treating a condition in a subject, comprising administering to the subject a MIL comprising a CAR. In some aspects, the condition is cancer, such as prostate cancer.
    Type: Application
    Filed: February 1, 2021
    Publication date: May 27, 2021
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Ivan Borrello, Eric R. Lutz, Lakshmi Rudraraju, Srikanta Jana, Ido Weiss, Valentina Hoyos
  • Prostate Cancer Specific Marrow Infiltrating Lymphocytes and Uses Thereof
    Publication number: 20210000876
    Abstract: The disclosure provides for compounds comprising prostate cancer specific marrow infiltrating lymphocytes and methods for making and using the same.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 7, 2021
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Ivan Borrello
  • Compositions and Methods for Modulating the Immune System
    Publication number: 20190330306
    Abstract: Embodiments provided for herein relate to compositions and methods related to chimeric proteins that can be used to modulate a subject's immune system and, for example, treat cancer.
    Type: Application
    Filed: December 21, 2017
    Publication date: October 31, 2019
    Applicant: WINDMIL THERAPEUTICS, INC.
    Inventors: Kimberly A. Noonan, Eric R. Lutz, Ivan Borrello
  • Universal GM-CSF Expressing Bystander Human Cell Line
    Publication number: 20110287058
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Application
    Filed: July 29, 2011
    Publication date: November 24, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Hyam I. LEVITSKY, Ivan BORRELLO
  • Universal GM-CSF expressing bystander human K562 cell line
    Patent number: 8012469
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: September 6, 2011
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Hyam I. Levitsky, Ivan Borrello
  • UNIVERSAL GM-CSF EXPRESSING BYSTANDER HUMAN K562 CELL LINE
    Publication number: 20080260758
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 23, 2008
    Applicant: The Johns Hopkins University
    Inventors: Hyam I. Levitsky, Ivan Borrello
  • Universal GM-CSF expressing bystander human K562 cell line
    Patent number: 7390483
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: June 24, 2008
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Hyam I. Levitsky, Ivan Borrello
  • Cancer immunotherapy with a viral antigen-defined, immunomodulator-secreting cell vaccine
    Publication number: 20060233770
    Abstract: A human cell line, which lacks major histocompatibility class I (MHC-I) antigens and major histocompatibility class II (MHC-II) antigens and which has been modified to comprise and express (i) a nucleotide sequence encoding an immunomodulator and (ii) a nucleotide sequence encoding a viral antigen, and a method of inducing or stimulating an immune response in a human to a viral-associated disease or cancer comprising administering to the human (i) the aforementioned human cell line in an amount sufficient to induce or stimulate an immune response to the viral associated disease or cancer, (ii) a human cell line, which lacks MHC-I and MHC-11 antigens and which has been modified to comprise and express a nucleotide sequence encoding an immunomodulator, and a human cell line, which lacks MHC-I and MHC-II antigens and which has been modified to comprise and express a nucleotide sequence encoding an antigen of EBV, simultaneously or sequentially in either order, by the same or different routes, in amounts sufficie
    Type: Application
    Filed: September 19, 2003
    Publication date: October 19, 2006
    Applicant: Johns Hopkins University School of Medicine
    Inventors: Richard Ambinder, Yiping Yang, Ivan Borrello, Hyam Levitsky
  • Universal GM-CSF expressing bystander human K562 cell line
    Publication number: 20060140922
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Application
    Filed: February 23, 2006
    Publication date: June 29, 2006
    Applicant: JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: Hyam Levitsky, Ivan Borrello
  • Universal GM-CSF expressing bystander human K562 cell line
    Patent number: 6464973
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: October 15, 2002
    Assignee: Johns Hopkins University, School of Medicine
    Inventors: Hyam I. Levitsky, Ivan Borrello
  • Universal immunomodulatory cytokine-expressing bystander cell line and related compositions and methods of manufacture and use
    Publication number: 20020037282
    Abstract: The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell line, and a method of using such a composition.
    Type: Application
    Filed: November 16, 2001
    Publication date: March 28, 2002
    Applicant: Johns Hopkins University School of Medicine
    Inventors: Hyam I. Levitsky, Ivan Borrello