Abstract: Methods, systems, and devices for experimental programs are described. A method includes acquiring baseline PPG data from a user via a wearable device throughout a time interval, and displaying one or more experimental programs via a user device based on the baseline PPG data, where each experimental program is associated with one or more behavioral changes. Upon a selection of an experimental program, the method includes acquiring additional PPG data from the user via the wearable device throughout a time interval of the experimental program. The method includes identifying adherence of the user to a behavioral change of the experimental program based on the additional PPG data and/or information received via the user device. The method further includes displaying, via the user device, changes between the baseline PPG data and the additional PPG data based on identifying the adherence to the behavioral change.

Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors (CAR) and/or genetically modified to reduce potential side effects of cellular immunotherapy. Several embodiments relate to genetic modifications to the immune cells, such as Natural Killer (NK) cells, to reduce, substantially, reduce, or eliminate expression of a combination of genes and their corresponding proteins. In several embodiments, one edit is to reduce expression of a marker by the immune cells that would otherwise cause them to be self-targeted by the CAR and at least two additional gene edits to enhance the cytotoxicity and/or persistence of the resulting cells. In several embodiments, the CAR targets CD70, and in some embodiments is used for renal cell carcinoma immunotherapy.

Abstract: Several embodiments disclosed herein relate to methods and compositions for enhanced expansion of NK cells in culture. In several embodiments, the methods utilize one or more soluble interleukins as culture media supplements at one or more time points during expansion of the NK cell, or other immune cell, the expansion employing a feeder cell population.

Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors and/or genetically modified to enhance one or more aspects of the efficacy of the immune cells in cellular immunotherapy. Several embodiments relate to genetic modifications which reduce potential side effects of cellular immunotherapy. In several embodiments, combinations of cells are used to achieve both rapid and long-term tumor reduction with reduced or eliminated potential for graft versus host effects.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric antigen receptors (CAR) and/or genetically modified to reduce potential side effects of cellular immunotherapy. Several embodiments relate to genetic modifications to the immune cells, such as Natural Killer (NK) cells, to reduce, substantially, reduce, or eliminate expression of a marker by the immune cells that would otherwise cause them to be self-targeted by the CAR. In several embodiments, the CAR targets CD70, and in some embodiments is used for renal cell carcinoma immunotherapy.

Abstract: Several embodiments provided for relate to methods of using of anti-CD19 CAR expressing immune cells in immunotherapy. Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence. Several embodiments include methods of using of the anti-CD19 CAR expressing immune cells in immunotherapy.

Abstract: Several embodiments provided for relate to methods of using of anti-CD19 CAR expressing immune cells in immunotherapy. Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence.

Abstract: A system for controllably generating jitter in a serial data stream includes a frequency generator and first and second mixers. The frequency generator is configured to output in-phase and quadrature local oscillator signals with a local oscillator frequency of at least about 5 MHz. The local oscillator frequency varies between a selectable minimum frequency and a selectable maximum frequency. The first mixer is configured to mix a fixed frequency clock signal with the in-phase local oscillator signal to output a first mixer output. The second mixer is configured to mix the fixed frequency clock signal with the quadrature local oscillator signal to output a second mixer output. An adder is configured to add the first and second mixer outputs to produce a frequency-modulated clock signal with a frequency that is about the sum of the fixed frequency and the local oscillator frequency and includes a periodic jitter.

Abstract: A system for controllably generating jitter in a serial data stream includes a frequency generator and first and second mixers. The frequency generator is configured to output in-phase and quadrature local oscillator signals with a local oscillator frequency of at least about 5 MHz. The local oscillator frequency varies between a selectable minimum frequency and a selectable maximum frequency. The first mixer is configured to mix a fixed frequency clock signal with the in-phase local oscillator signal to output a first mixer output. The second mixer is configured to mix the fixed frequency clock signal with the quadrature local oscillator signal to output a second mixer output. An adder is configured to add the first and second mixer outputs to produce a frequency-modulated clock signal with a frequency that is about the sum of the fixed frequency and the local oscillator frequency and includes a periodic jitter.

Abstract: An animated children's toy including a gear system for providing intermittent and reciprocal motion. The gear system includes a drive gear and a driven gear. The gear system is adapted to have a non-rotating configuration and an engaged configuration. In the non-rotating configuration the driven gear is prevented from rotating, and a corresponding portion of the animated children's toy is not moving. In the engaged configuration the driven gear rotates and a corresponding portion of the animated children's toy moves.

Abstract: Embodiments of the invention include an integrated circuit including a line driver. The integrated circuit includes a voltage mode driver comprising complementary first and second input voltage drivers, a programmable resistor network and a current mode driver. The programmable resistor network allows the amplitude of the line driver outputs to be controlled based on the particular resistor connections in the programmable resistor network. Also, the differential impedance of the integrated circuit and the common mode impedance of the integrated circuit are based on the resistance values of the resistors in the programmable resistor network.

Abstract: Embodiments of the invention include an integrated circuit including a line driver. The integrated circuit includes a voltage mode driver comprising complementary first and second input voltage drivers, a programmable resistor network and a current mode driver. The programmable resistor network allows the amplitude of the line driver outputs to be controlled based on the particular resistor connections in the programmable resistor network. Also, the differential impedance of the integrated circuit and the common mode impedance of the integrated circuit are based on the resistance values of the resistors in the programmable resistor network.

Abstract: The high frequency components of a SCSI signal are adaptively equalized using an adaptive filter having an adjustable gain. A comparator is used to compare an input signal with a predetermined threshold level. Based on the result of the comparison, the adjustable gain of the adaptive filter is modified.

Abstract: An animated children's toy including a gear system for providing intermittent and reciprocal motion. The gear system includes a drive gear and a driven gear. The gear system is adapted to have a non-rotating configuration and an engaged configuration. In the non-rotating configuration the driven gear is prevented from rotating, and a corresponding portion of the animated children's toy is not moving. In the engaged configuration the driven gear rotates and a corresponding portion of the animated children's toy moves.

Abstract: An apparatus mitigates inter-symbol interference effects on an oscillating signal from which digital data will be obtained at a receive end of a channel. The inter-symbol interference is introduced into the oscillating signal as a result of transmitting the oscillating signal through the transmission channel over a substantial distance from a transmit device to the receive end of the channel. A filter element receives an input signal from the transmit device and outputs a filtered signal within a predetermined frequency band. The filter element has a mechanism for adjusting a gain for a given range of frequencies within the predetermined frequency band. The given range of frequencies corresponds to higher frequencies in the predetermined frequency band. An amplitude determining mechanism determines a peak amplitude of the filtered signal.