Patents by Inventor Ivan D. Trifunovich

Ivan D. Trifunovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ?-Lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 7176326
    Abstract: Novel ?-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling ?-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: February 13, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Methods for the preparation of taxanes using oxazolidine intermediates
    Patent number: 6784304
    Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 31, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich
  • Method for the preparation of novel sidechain-bearing taxanes and intermediates thereof
    Patent number: 6515151
    Abstract: Methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Compounds prepared by the methods of the present invention are also disclosed.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: February 4, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
  • Novel methods for the preparation of taxanes using oxazolidine intermediates
    Publication number: 20020161238
    Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.
    Type: Application
    Filed: December 11, 2001
    Publication date: October 31, 2002
    Inventors: John K. Thottathil, Ivan D. Trifunovich
  • Novel beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Publication number: 20020137927
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Application
    Filed: December 5, 2001
    Publication date: September 26, 2002
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Methods for the preparation of taxanes using oxazolidine intermediates
    Patent number: 6365750
    Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: April 2, 2002
    Assignee: Bristol Myers Squibb Comp.
    Inventors: John K. Thottathil, Ivan D. Trifunovich
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6350887
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6350886
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6310201
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxes such as tall and tall derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxes, and to novel sidechain-bearing taxes.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: October 30, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Methods for the preparation of novel sidechain-bearing taxanes and intermediates
    Patent number: 6090951
    Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: July 18, 2000
    Inventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
  • Methods for the preparation of novel sidechain-bearing taxanes
    Patent number: 5973160
    Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: October 26, 1999
    Inventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei
  • Phosphorus bearing taxanes intermediates
    Patent number: 5808102
    Abstract: Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoline sidechain-bearing taxane, and opening the oxazoline ring of the oxazoline sidechain-bearing taxane so formed. Novel compounds prepared by the methods of the present invention are also provided.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: September 15, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Jerome L. Moniot, Ivan D. Trifunovich, David J. Kucera, John K. Thottahil, Shu-Hui Chen, Jianmei Wei