Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.

Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.

Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.

Abstract: The disclosure provides methods and apparatus for high speed and sterile sorting of heterogeneous populations of cells to isolate homogenous populations. In embodiments, the disclosure provides a micropore array and collection tray situated within a sterile, closed cartridge.

Abstract: A point-of-test diagnostic chip that is capable of simultaneous evaluation of blood coagulation time (INR Value) and hematocrit level. A finger prick volume of blood is placed at the inlet of the device, and the residual vacuum contained within the device provides a pressure gradient to drive the flow of whole blood. The INR value is determined by the distance the blood traverses down the channel before it coagulates. The channel is primed with tissue factor and phospholipids to induce coagulation. A control channel is primed with anticoagulants for use as a way to normalize initial loading times. The hematocrit level is determined by sedimentation of blood cells into a trench and the interface between blood cells that have overfilled the trench and plasma provide a visual readout.

Abstract: The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic, and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e. millions-billions) but with greater efficiency and shorter time.

Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.

Abstract: Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high-throughput analysis of cells and protein products use a range of fluorescent assays, including binding-affinity measurement and time-resolved enzyme assays. Laser-based extraction of microcavity contents.

Abstract: The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time.

Abstract: A point-of-test diagnostic chip that is capable of simultaneous evaluation of blood coagulation time (INR Value) and hematocrit level. A finger prick volume of blood is placed at the inlet of the device, and the residual vacuum contained within the device provides a pressure gradient to drive the flow of whole blood. The INR value is determined by the distance the blood traverses down the channel before it coagulates. The channel is primed with tissue factor and phospholipids to induce coagulation. A control channel is primed with anticoagulants for use as a way to normalize initial loading times. The hematocrit level is determined by sedimentation of blood cells into a trench and the interface between blood cells that have overfilled the trench and plasma provide a visual readout.

Abstract: A sequential flow analysis tool comprising a microfluidic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

Abstract: The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time.

Abstract: A device for blood-plasma separation and plasma-based blood analysis is described. The device uses blood samples smaller than 5 ?L, (directly from the finger) and flow is achieved with a degassing-driven flow technique that causes blood to flow spontaneously into air-filled dead-end channels without external pumping mechanisms.

Abstract: The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment using a gas plasma reactor. Judicious selection of a precursor compound used within the gas plasma reactor can provide for generation of a layer on the individual surfaces. Desirably the surface or barrier layer is generated through the chemical adsorption of a metalloid oxide such as a silicon oxide layer on the surface of the individual channels or cavities.

Abstract: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.

Abstract: A docking module for conventional small form factor disk drives provides, in one embodiment, space for two such disk drives embedded in tray loaders, within a standard 3.5 inches halve height floppy bay. The docking module provides hot swappable insertion and removal of tray loaders together with disk drives. The bay is provided within a housing member. A button attached to a lever mechanism disconnects the docking module connector from the tray loader connector and partially pull out the loader when the button is pushed; An EMI shield fixedly coupled to the tray loaders each provide a barrier to electromagnetic interference.

Abstract: A nickel-free corrosion-resistant steel which consists by weight of:Carbon .ltoreq. 0.08%Silicon .ltoreq. 0.9%Chromium = 18.05 to 22%Manganese = 6.0 to 10.5%Nitrogen = 0.40 to 1.10%Sulfur .ltoreq. 0.025%Phosphorus .ltoreq. 0.035%Copper .ltoreq. 3% and the remainder iron.

Abstract: A method of injection molding foamed articles wherein, after the mold is closed and while the mold is held closed, a gas counterpressure is generated within the mold cavity against which a portion of the foamable resin is injected under a pressure which prevents foaming. Thereafter, a shape-forming element adapted to be retracted to be flush with a wall of the mold cavity in the final phase thereof, is advanced to force the nonfoamed material, still against the gas counterpressure, into the remainder of the cavity. After a skin has formed, on the mass within the mold cavity the latter element is retracted to permit foaming, preferably after foaming has been initiated by allowing a portion of the foamable mass to recede into the injection cylinder during the inception of the foaming process.

Abstract: An injection molding machine in which a support on a base carries oppositely facing stationary mold portions which, when joined by movable mold portions, form a pair of mold cavities, one of which can be injected with a moldable material having a long solidification time, while the other contains a previously injected article which is solidifying and can be released as soon as the injection of the first cavity is completed. One of the movable mold portions is connected to a movable plate in a fixed spaced relationship, with a wedge-type locking mechanism between the plate and the other movable mold portion for the locking of both mold cavities simultaneously with a single locking mechanism.

Abstract: An apparatus for casting a molten material in which the mold is received in one chamber and the molten material is received in another chamber, the two chambers being subject to different pressures so that a tube connecting them can deliver the molten material from the second chamber to the first under a pressure differential. Signal-producing apparatus connected to the mold chambers produce signals representing the two pressures and the pressure differential, the signal-producing apparatus being connected to differentiating apparatus whose output produces time derivatives of the pressures and pressure differential. The time derivatives can be used to control the pressures via a comparator to which a reference value or set point signal is applied thereby varying the rate of filling of the mold in accordance with a predetermined program.