Abstract: “Enhydrazone esters of formula (I): wherein R is methyl or ethyl group have been synthesized. The compounds of formula (I) are potent inhibitors of degranulation of both mast cells and eosinophils. These compounds also suppress cytokines generation by leukocytes. These biological activities are relevant to the prevention and/or treatment of asthma, allergies and inflammatory diseases. It is known to the art that inhibitors of mast cell degranulation such as cromolyn sodium and nedocromil sodium are used in the treatment of asthma and other allergic diseases. Inhibitors of cytokine generation, such as steroids, are also useful in the prevention and treatment of inflammatory diseases as well as asthma and allergies”.

Abstract: The invention is the new and unique use of Enaminone E121 for its significant anti-tussive and anti-bronchoconstrictor actions. E121 has direct airway smooth muscle (ASM) relaxant effect. The combined antitussive/bronchodilatory effects of E121 make the compound a novel respiratory drug that may be effective in treatment of some types of cough and also cough associated with airway flow obstruction.