Abstract: Systems and methods for generating adaptive layouts can receive space data relating to a space. The space data includes sensor data from a set of one or more sensors in the space and activity data related to work being performed in the space. The received space data can be analyzed to determine space characteristics data. The space characteristics data includes physical space data related to physical features in the space, work mode data related to types of work performed by users in the space, and user data related to individual users working in the space. Layout data can be generated based on the space characteristic data. The layout data includes positions for several work zones in the space and a target work mode for each work zone of the several work zones. Outputs can be generated based on the generated layout data.