Abstract: A holding member for fixing a timepiece component on support elements of different cross section includes an opening into which each support element can be inserted, the holding member having structural elements together forming a body configured to ensure mounting of each support element in the opening. Each of the structural elements includes a first structural sub-element and a second structural sub-element, the first structural sub-element including a volume of material greater than a volume of material constituting the second structural sub-element. The holding member includes a connecting portion ensuring the mounting of each of the support elements in the holding member, the portion being defined on an inner face of the first structural sub-element.

Abstract: The present disclosure relates in some aspects to methods and compositions for analysis of a target nucleic acid, such as in situ detection of a region of interest in a polynucleotide in a tissue sample. In some embodiments, provided herein are templated ligation probes (e.g., RNA-templated ligation probes) and selector probes for generation of a circularized ligated probe comprising an insertion sequence of a selector probe, wherein the circularized ligated probe is amplified in a rolling circle amplification reaction to generate a product that is detected in the sample.

Abstract: An elastic retaining member is for attaching a horological component to a support element. The retaining includes an opening into which the support element is capable of being inserted. The retaining member also includes rigid arms and elastic arms defined between the connection zones of the retaining member. The arms contribute to procuring elastic gripping of the support element in the opening, each rigid arm being provided with a single convex contact zone of the retaining member capable of engaging with a corresponding convex contact portion of the support element.

Abstract: An elastic securing organ for fastening a horological component on a support element including an outer peripheral wall capable of being connected to said horological component and an inner peripheral wall defining a triangular-shaped opening wherein the support element is capable of being inserted, the elastic securing organ includes elastic arms each forming one side of the triangular opening and helping ensure the gripping of the support element in the opening, each arm including: at least one cut-out defined completely or partially along the body of said arm, an elastic contact zone with the support element, and elastic peripheral zones which extend between this contact zone and the ends of this elastic arm, the contact zone having a greater quantity of material than the quantity of material forming each of the peripheral zones thereof.

Abstract: An elastic holding member including a body provided with rigid portions and deformable portions each provided with a through hole, the member being intended for attaching a horological component to a support element and including an opening the contour of which includes three contact zones intended to come into abutment on the support element, the contact zones each being included on an internal face of a reception region of each deformable portion.

Abstract: An elastic fastening element for holding a timepiece component on a support element, including an opening the contour of which includes at least four contact areas for receiving and clamping the support element in the opening, the contact areas each being included on an inner face of a deformable portion provided with a through-hole of the fastening element.

Abstract: An attachment monolithic part for fastening a timepiece component on a support element, including an opening into which the support element could be inserted, the attachment part including elastic arms contributing to ensuring an elastic clamping of the support element in the opening, each arm consisting of a contact portion provided with a through hole and with a connecting portion, the contact portion including a receiving region provided with a bearing area intended to come into contact with the support element and the connecting portion ensuring an elastic connection with another one of the arms of the part.

Abstract: A spiral spring for a horological resonator mechanism, including a flexible strip (2) coiled on itself into several turns The spring (1) including an element for adjusting its stiffness, which includes a first elongate flexible element (5), and a second elongate flexible element (15) arranged in series with the strip (2), each elongate flexible element (5) connecting the same end (4) of the strip (2) to a fixed support (11), so as to add an additional stiffness to the strip (2), each elongate flexible element (5) preferably having a stiffness higher than that of the strip (2). A prestressing element (6) applies at least two different adjustable efforts, the two efforts being applied on the first elongate flexible element (5) so as to make the stiffness of the first elongate flexible element (5) vary according to the prestress level.

Abstract: A spiral spring for a horological resonator mechanism, including a flexible strip (2) coiled on itself into several turns, the strip (2) having a predefined stiffness. The spring (1) include an element for adjusting its stiffness, including a unique elongate flexible element (5) arranged in series with the strip (2), and connecting one end (4) of said strip (2) to a fixed support (11), to add additional stiffness. The flexible element (5) has a stiffness higher than that of the strip (2). A prestressing element (6) applies two different efforts on the element (5), and includes a first lever (8) attached to the end (4) of the strip (2) to allow adjusting a first effort, and a second lever (8) also attached to the end (4) of the strip (2) to adjust a second effort independently of the first effort.

Abstract: The invention relates to an elastic retaining member (1) for fixing a timepiece component (2) on a support element (3), comprising an opening (5) into which said support element (3) can be inserted, the retaining member (1) comprising rigid arms (6) and elastic arms (7) defined between connection areas (9) contributing to ensure elastic clamping of the support element (3) in the opening (5) each rigid arm (6) being provided with two flat contact areas (8) of the retaining member (1) able to cooperate with corresponding convex contact portions (10) of the support element (3).

Abstract: An elastic retaining member for fixing a timepiece component on a support element includes an opening into which the support element can be inserted, and rigid arms and elastic arms defined between connection areas of the member. The rigid arms and the elastic arms are configured to ensure elastic clamping of the support element in the opening, each of the rigid arms being provided with a single flat contact area and configured to cooperate with a corresponding convex contact portion of the support element.

Abstract: Techniques are described for exporting observability data related to execution of a service from a first cloud environment to a second cloud environment. The service is executed in the first cloud environment for a customer of a second cloud environment. Observability data associated with execution of the service is collected in the first cloud environment for the customer of the second cloud environment. The observability data comprises one or more metrics associated with the execution of the service. The observability data collected from the first cloud environment is communicated to the second cloud environment to enable a user associated with the customer of the second cloud environment to access the observability data via the second cloud environment.

Abstract: A multi-cloud infrastructure included in a first cloud environment provided by a first cloud services provider generates a set of one or more graphical user interfaces for each of a plurality of external cloud environments that are provided by a plurality of external cloud services providers. The set of one or more graphical user interfaces for an external cloud environment of the plurality of external cloud environments is generated based upon a native graphical user interface provided by the external cloud environment. Responsive to a request received by the first cloud environment and from a first external cloud environment of the plurality of external cloud environments, providing as a response to the request, a first graphical user interface from the set of one or more graphical user interfaces generated for the first external cloud environment.

Abstract: The present disclosure in some aspects relates to methods and compositions for detecting and quantifying multiple analytes present in a biological sample by rolling circle amplification (RCA). In some aspects, the methods and compositions provided herein address issues associated with control of signal spot size and intensity for RCA products (RCPs) in a sample. In some aspects, provided herein are methods and compositions (e.g., probes and/or reaction mixtures) for slowing down RCA and/or decreasing the size of RCA products. In some embodiments, nucleotides or nucleotide analogs having a hydrophobic group (e.g., a hydrophobic modification on the base) are included in nucleotides for RCA and incorporated into the RCP product, leading to reduction of RCP size without the need of crosslinking an incorporated hydrophobic nucleotide or nucleotide analog to the RCP itself or another molecule.

Abstract: A balance-spring, particularly for a timepiece resonator mechanism. An adjustment device include a single elongated flexible element (5) arranged in series of strip (2), connecting one end (4, 9) of said strip (2) to a fixed support (11), to add an additional stiffness to the strip (2), and having a stiffness greater than that of the strip (2). A prestressing means (6) applies at least two different stresses on the elongated flexible element (5), the first stress being provided by a tensile/compressive force directed substantially in the longitudinal direction FL of the elongated flexible element (5), and the second stress being provided, either by a force directed substantially in a direction substantially orthogonal FT to the longitudinal direction of the elongated flexible element (5), or by a torque M, preferably a bending moment, in such a way as to vary the stiffness of the elongated flexible element (5).

Abstract: The present disclosure in some aspects relates to methods and compositions for accurately detecting and quantifying multiple analytes present in a biological sample. In some aspects, the methods and compositions provided herein address one or more issues associated with the stability and/or size of nucleic acid structures such as rolling circle amplification products in the biological sample.

Abstract: The present disclosure in some aspects relate to a direct RNA (dRNA) detection approach incorporating the use of circularizable probes (e.g., padlock probes) having asymmetric arms, rolling circle amplification of the ligated circularizable probes, and in situ detection (e.g., using hybridization-based in situ sequencing) for multiplexed spatial analysis of nucleic acid sequences (e.g., short sequences such as SNPs and point mutations) in a biological sample. In some aspects, compositions and methods disclosed herein improve detection specificity, reduce false positive signal detection, and/or maintain or improve detection efficiency.

Abstract: A balance for a horological movement, including rigid parts including a hub defining the pivot axis of the balance, a felloe sector, at least one arm connecting the felloe sector to the hub, and including a slot for receiving and gripping an inertia-block in position, the slot opening into a housing delimited on the one hand by a rigid part of the balance, and on the other hand an elastic arm including a first end integral with a rigid part of the balance, and a second free distal end. The elastic arm has a hook-shaped body, the free distal end of the hook being parallel to a part of the balance having a rigidity greater than or equal to that of the elastic arm.

Abstract: The present disclosure in some aspects relates to methods and compositions for accurately detecting and quantifying multiple analytes present in a biological sample. In some aspects, the methods and compositions provided herein address one or more issues associated with the stability and/or size of nucleic acid structures, such as RCPs, in the biological sample without the use of exogenously added oligonucleotide compaction probes. In some embodiments, provided herein are methods involving the use of self-hybridizing hybridizing regions for compacting and/or stabilizing nucleic acid concatemers (e.g., RCPs). In some embodiments, dynamic inter-strand annealing between tandem units of an RCP is used for compaction and/or stabilization. In some embodiments, short palindromic regions in an RCP are used for compaction and/or stabilization.