Abstract: The invention relates to compounds according to Formula (I): wherein A is —As(OH)2 or an arsenoxide equivalent group; each of R1, R2, R3 and R4 is independently selected from H, X, OH, NH2, CO, SCN, —CH2NH, —NHCOCH3, —NHCOCH2X or NO, and X is a halogen; R5 is —NHCH2COOH, OH or OR6, wherein R6 is a C1-5 straight or branched alkyl group; and Z is a radioisotope with a half-life of less than 4 days, or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, uses of said compounds, and methods of preparing said compounds. The invention also relates to diagnostic methods utilizing said compounds.

Abstract: The invention relates to compounds according to Formula (I) wherein A is —As(OH)2 or an arsenoxide equivalent group; each of R1, R2, R3 and R4 is independently selected from H, X, OH, NH2, CO, SCN, —CH2NH, —NHCOCH3, —NHCOCH2X or NO, and X is a halogen; R5 is —NHCH2COOH, OH or OR6, wherein R6 is a C1-5 straight or branched alkyl group; and Z is a therapeutic radioisotope, or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, uses of said compounds, and methods of preparing said compounds. The invention also relates to therapeutic methods utilizing said compounds. The invention further relates to processes for preparing compounds according to Formula (I) wherein Z is a radioisotope.

Abstract: The present disclosure provides methods and compositions relating to isolated CD8+ T cells expressing a disease antigen-specific T cell receptor, as well as nucleic acids encoding the V? and V? polypeptide pairs of T cell receptors (TCRs) of such disease antigen-specific T cells. Such disease antigen-specific CD8+ T cells are obtainable from the periphery (e.g., blood) of a subject having a disease amenable to treatment with an IL-10 agent. The present disclosure also contemplates therapeutic methods and compositions relating to administration of isolated disease antigen-specific CD8+ T cells to a subject, as well as therapeutic methods and compositions relating to CD8+ T cells genetically modified to express a disease antigen-specific TCR and/or chimeric antigen receptor.

Abstract: Methods of treating subjects having diseases, disorders, or conditions, including cancer and immune- and inflammatory-related disorders, via the administration of IL-10 in combination with one or more additional agents, and methods and models associated therewith, are provided.

Abstract: The invention relates to compounds according to Formula (I) wherein A is —As(OH)2 or an arsenoxide equivalent group; each of R1, R2, R3 and R4 is independently selected from H, X, OH, NH2, CO, SCN, —CH2NH, —NHCOCH3, —NHCOCH2X or NO, and X is a halogen; R5 is —NHCH2COOH, OH or OR6, wherein R6 is a C1-5 straight or branched alkyl group; and Z is a radioisotope with a half-life of less than 4 days, or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, uses of said compounds, and methods of preparing said compounds. The invention also relates to diagnostic methods utilizing said compounds.

Abstract: Methods of treating subjects having a proliferative disease, disorder, or condition, including cancer, via the administration of an IL-10 agent, including pegylated IL-10, in combination with an antibody capable of inducing anti-body-dependent cell-mediated cytotoxicity, are provided.

Abstract: An intelligent fitness set and anti-cheating method thereof is disclosed. The intelligent fitness set includes a support, a base, a plurality of handheld fitness equipments and two handles, wherein a processor, a movement posture sensor and a touch sensor are provided in each handle, and the movement posture sensor and the touch sensor are connected respectively with the processor. One end of each handle is closed, while a bayonet is provided in the other end of the handle and the switchable hot-pluggable bayonet is configured to connect respectively to the plurality of handheld fitness equipments. In the present disclosure, one set of action training of a plurality of handheld fitness equipments is performed through the same set of handles, so that a user can complete movement of one time only by strictly complying with active standards during movement.

Abstract: Methods of treating subjects having a cancer-related disease, disorder, or condition, or preventing the occurrence of such a disease, disorder or condition, via the administration of a PEG-IL-10 agent in combination with an IL-15 agent are provided.

Abstract: Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to agents modulating Kupffer cell function, including methods of administration and dosing regimens associated therewith, are provided. Methods of treating subjects having liver diseases, disorders, or conditions, including non-alcoholic steatohepatitis and non-alcoholic fatty liver disease, with an IL-10 agent are also provided.

Abstract: Methods of modulating immune responses in subjects having oncology- and immune-related diseases, disorders and conditions by the administration of an IL-10 agent, including pegylated IL-10.

Abstract: Methods of modulating immune responses in subjects having oncology- and immune-related diseases, disorders and conditions by the administration of an IL-10 agent, including pegylated IL-10.

Abstract: The present disclosure provides methods and compositions relating to isolated CD8+ T cells expressing a disease antigen-specific T cell receptor, as well as nucleic acids encoding the V? and V? polypeptide pairs of T cell receptors (TCRs) of such disease antigen-specific T cells. Such disease antigen-specific CD8+ T cells are obtainable from the periphery (e.g., blood) of a subject having a disease amenable to treatment with an IL-10 agent. The present disclosure also contemplates therapeutic methods and compositions relating to administration of isolated disease antigen-specific CD8+ T cells to a subject, as well as therapeutic methods and compositions relating to CD8+ T cells genetically modified to express a disease antigen-specific TCR and/or chimeric antigen receptor.

Abstract: Methods of treating subjects having a cancer-related disease, disorder, or condition, or preventing the occurrence of such a disease, disorder or condition, via the administration of a PEG-IL-10 agent in combination with an IL-15 agent are provided.

Abstract: A switchable intelligent fitness handle is disclosed. A processor (11), a movement posture sensor (12) and a touch sensor (13) are built in the handle (7). The movement posture sensor (12) and the touch sensor (13) are connected to the processor (11). Each handheld fitness equipment has a corresponding sensor, and a pin connector (16, 17, 18, 19) that is matched with the bayonet (15) of the handle and provided with a signal line. Thus, the goal of accomplishing a set of exercises with a plurality of handheld fitness equipments by using one same set of handles can be achieved. An intelligent fitness set containing the fitness handle is further disclosed.

Abstract: Methods of treating subjects having a cancer-related disease, disorder, or condition, or preventing the occurrence of such a disease, disorder or condition, via the administration of a PEG-IL-10 in combination with an IL-12 agent are provided.

Abstract: An intelligent fitness set and anti-cheating method thereof is disclosed. The intelligent fitness set includes a support, a base, a plurality of handheld fitness equipments and two handles, wherein a processor, a movement posture sensor and a touch sensor are provided in each handle, and the movement posture sensor and the touch sensor are connected respectively with the processor. One end of each handle is closed, while a bayonet is provided in the other end of the handle and the switchable hot-pluggable bayonet is configured to connect respectively to the plurality of handheld fitness equipments. In the present disclosure, one set of action training of a plurality of handheld fitness equipments is performed through the same set of handles, so that a user can complete movement of one time only by strictly complying with active standards during movement.

Abstract: Pegylated interleukin-15—related molecules and the identification thereof are described. The pegylated interleukin-15 molecules exhibit properties and characteristics that make them candidates for therapeutic use. Pharmaceutical compositions and methods of use are also described herein. 1C.

Abstract: A switchable intelligent fitness handle is disclosed. A processor (11), a movement posture sensor (12) and a touch sensor (13) are built in the handle (7). The movement posture sensor (12) and the touch sensor (13) are connected to the processor (11). Each handheld fitness equipment has a corresponding sensor, and a pin connector (16, 17, 18, 19) that is matched with the bayonet (15) of the handle and provided with a signal line. Thus, the goal of accomplishing a set of exercises with a plurality of handheld fitness equipments by using one same set of handles can be achieved. An intelligent fitness set containing the fitness handle is further disclosed.

Abstract: Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to IL-10, including methods of administration and dosing regimens associated therewith, are provided.

Abstract: A web cam device includes a camera housing, a camera disposed in the camera housing, a data cable coupled to the camera that extends from the camera housing, and a base including an aperture to receive the data cable such that the base is slideable along the data cable, where the aperture provides a sliding friction to the data cable, and where the camera is operable to be mounted on a monitor when the camera is positioned on a front of the monitor, the data cable is configured to pass through the aperture of the base, and the base is secured against the back of the monitor and held by the sliding friction of the aperture on the data cable. The camera housing can include a protrusion extending from the camera housing and is flush against the front of the monitor when the camera is mounted on the display device.