Abstract: The present invention is related to a method of identifying at least one sequence of target regions on a plurality of macromolecules to test, each target region being associated with a tag and said macromolecules having underwent linearization according to a predetermined direction, wherein said method comprises performing by a processor (11) of equipment (10) the following steps: (a) receiving from a scanner (2) being sensitive to said tags, at least one sample image depicting said macromolecules as curvilinear objects sensibly extending according to said predetermined direction; (b) Generating a binary image from the sample age; (c) For at least one template image, and for each sub-area of the binary image having the same size as the template image, calculating a correlation score between the sub-area and the template image; (d) For each sub-area of the binary image for which the correlation score with a template image is above a first given threshold, selecting the corresponding sub-area of the sample imag

Abstract: An automated, computer-implemented method for detecting and measuring large amounts of data obtained from molecular combing procedures including the identification and characterization of seven different DNA replication initiation and termination patterns.

Abstract: The present invention is related to a method of analyzing a set of sequences of target regions on a plurality of macromolecules to test so as to detect anomalies therein, each target region being associated with a tag and said macromolecules having underwent linearization according to a predetermined direction, wherein said method comprises performing by a processor (11) of equipment (10) the following steps: (a) Identifying said sequences of target regions from at least one sample image received from a scanner (2), said sample image depicting said macromolecules as curvilinear objects sensibly extending according to said predetermined direction; (b) Determining if there is at least one target region presenting a bimodal distribution of the lengths of said target region; (c) Determining if there is at least one recurrent breakpoint position in said sequences of target regions; If at least one target region presenting a bimodal distribution of length and/or at least one recurrent breakpoint position has been d