Patents by Inventor Ivan N Rich

Ivan N Rich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of reducing cell proliferation by inhibiting the Na+/H+ exchanger and inducing apoptosis
    Patent number: 6355410
    Abstract: The Na+/H+ exchanger isoform 1 (NHE-1) is primarily responsible for the regulation of the intracellular pH (pHi). It is a ubiquitous amiloride-sensitive growth factor activatable exchanger. There is a direct correlation between the pHi and cell cycle status of normal hemopoietic and leukemic cells, with leukemic cells having a higher pHi than normal hemopoietic cells. A method is provided to sort cells by flow cytometry into subpopulations of proliferating and non-proliferating cells and to induce apoptosis in proliferating leukemic cells by inhibiting the Na+/H+ exchanger, thereby lowering the internal pHi.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: March 12, 2002
    Inventor: Ivan N Rich