Patents by Inventor Ivan Ogibalov

Ivan Ogibalov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED ANTHRACYCLINE DELIVERY SYSTEM FOR CANCER TREATMENT
    Publication number: 20230320986
    Abstract: The present invention relates to a drug delivery system at least comprising a drug encapsulated in a polymeric nano vesicle (polymersome), wherein the drug component is an anthracycline derivative according to the formula I wherein R1 is selected from the group consisting of H, F, —OMe or —OEt; R2 is selected from the group consisting of H, —OMe, methyl or ethyl; R3 is selected from the group consisting of H, methyl or ethyl, and R4 is H or a protecting group; the polymersome is formed by polymers comprising PEG, PEA, PCL, PTMC or PTMB building blocks or combinations thereof, wherein the polymersome polymers are, at least in part, functionalized by chemically attaching via a linker group L a targeting moiety, wherein the targeting moiety is selected from the group consisting of antibodies, peptides, aptamers or mixtures thereof.
    Type: Application
    Filed: July 29, 2021
    Publication date: October 12, 2023
    Inventors: Olga TSUBRIK, Andrus TASA, Ain UUSTARE, Ivan OGIBALOV, Tambet TEESALU, Lorena Simón GRACIA, Valeria SIDORENKO
  • PROCESS FOR THE PREPARATION OF ARYLSULFONYLPROPENENITRILES
    Publication number: 20220002241
    Abstract: The present invention relates to a process for the preparation of arylsulfonylpro-penenitriles. The reaction starting from arylsulfonyl halides is catalyzed by a cat-alyst compound comprising a transition metal. The process is scalable, environ-mentally benign and provides the product in good yield.
    Type: Application
    Filed: November 4, 2019
    Publication date: January 6, 2022
    Inventors: Jaakko HILTUNEN, Petteri SUOMINEN, Ivan OGIBALOV, Ain UUSTARE
  • Antibody-drug-conjugates comprising novel anthracycline-derivatives for cancer treatment
    Patent number: 10668166
    Abstract: The present invention relates to novel anthracycline derivatives comprising two oxazolidine cycles and the preparation of said anthracycline derivatives. Furthermore, antibody-drug conjugates (ADCs) comprising the novel anthracycline derivatives and the use of such ADCs in the prevention and treatment of cancer are disclosed.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 2, 2020
    Assignee: Toxinvent Ou
    Inventors: Ain Uustare, Ivan Ogibalov, Olga T{hacek over (s)}ubrik, Andrus Tasa, Uno Mäeorg, Ago Rinken
  • ANTIBODY-DRUG-CONJUGATES COMPRISING NOVEL ANTHRACYCLINE-DERIVATIVES FOR CANCER TREATMENT
    Publication number: 20190262464
    Abstract: The present invention relates to novel anthracycline derivatives comprising two oxazolidine cycles and the preparation of said anthracycline derivatives. Furthermore, antibody-drug conjugates (ADCs) comprising the novel anthracycline derivatives and the use of such ADCs in the prevention and treatment of cancer are disclosed.
    Type: Application
    Filed: May 30, 2017
    Publication date: August 29, 2019
    Inventors: Ain Uustare, Ivan Ogibalov, Olga Tsubrik, Andrus Tasa, Uno Mäeorg, Ago Rinken